Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction

  • Authors:
    • Lilin Chen
    • Qihua Yang
    • Rui Ding
    • Dan Liu
    • Zhijun Chen
  • View Affiliations / Copyright

    Affiliations: Stroke Office, Jingmen First People's Hospital, Jingmen, Hubei 448000, P.R. China, Department of Ultrasound Imaging, Jingmen First People's Hospital, Jingmen, Hubei 448000, P.R. China, Department of Neurosurgery, Jingmen First People's Hospital, Jingmen, Hubei 448000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5253-5257
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/etm.2018.6868
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Correlations of carotid intima‑media thickness (IMT), atherosclerotic plaque stability, serum inflammatory factors and serum matrix metalloproteinase (MMP)‑2 and MMP‑9 levels with the condition of disease in patients with acute cerebral infarction were analyzed to explore the predictive value of these risk factors. A total of 56 patients diagnosed with acute cerebral infarction in Jingmen First People's Hospital from February 2016 to January 2017 were selected and divided into the plaque stability group (n=25) and plaque instability group (n=31). Our results showed that the level of total cholesterol (TC) in the plaque instability group was significantly higher than that in the plaque stability group (P<0.05). IMT and National Institutes of Health Stroke Scale (NIHSS) score in the plaque instability group were significantly higher than those in the plaque stability group, but eccentricity index (EI) and Barthel index were significantly lower than those in the plaque stability group (P<0.05). The serum C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α) and interleukin‑6 (IL‑6) levels in the plaque instability group were significantly higher than those in the plaque stability group (P<0.05). The levels of serum MMP‑2 and MMP‑9 in the plaque instability group were significantly higher than those in the plaque stability group (P<0.05). Barthel index was correlated with IMT (r=‑0.693, P<0.01), MMP‑2 (r=‑0.605, P<0.01), CRP (r=‑0.765, P<0.01) and EI (r=0.811, P<0.01), respectively. Hemoglobin A1c (HbA1c), TC, systolic blood pressure, coronary heart disease, diabetes mellitus, IMT, EI, CRP, TNF‑α, IL‑6, MMP‑2 and MMP‑9 had independent predictive values for acute cerebral infarction (P<0.05). Carotid IMT, stability of the atherosclerotic plaque, serum inflammation, serum MMP‑2 and MMP‑9 levels have close correlations with acute cerebral infarction. The larger the carotid IMT is, the more unstable the plaque is and the higher the levels of serum inflammatory factors, MMP‑2 and MMP‑9 are, the greater the risk of acute cerebral infarction will be.
View Figures

Figure 1

Figure 2

View References

1 

Kim HM, Shin HY, Jeong HJ, An HJ, Kim NS, Chae HJ, Kim HR, Song HJ, Kim KY, Baek SH, et al: Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage. J Mol Neurosci. 14:191–196. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Dziedzic T: Clinical significance of acute phase reaction in stroke patients. Front Biosci. 13:2922–2927. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Liapis CD, Kakisis JD and Kostakis AG: Carotid stenosis: Factors affecting symptomatology. Stroke. 32:2782–2786. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Ma LL, Song L, Yu XD, Yu TX, Liang H and Qiu JX: The clinical study on the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia. Eur Rev Med Pharmacol Sci. 21:1999–2006. 2017.PubMed/NCBI

5 

Segers D, Helderman F, Cheng C, van Damme LC, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AF, Holvoet P, et al: Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo. Circulation. 115:609–616. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Moreno PR, Purushothaman KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK, Badimon JJ and O'Connor WN: Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: Implications for plaque vulnerability. Circulation. 110:2032–2038. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Casas JP, Shah T, Hingorani AD, Danesh J and Pepys MB: C-reactive protein and coronary heart disease: A critical review. J Intern Med. 264:295–314. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Doyle B and Caplice N: Plaque neovascularization and antiangiogenic therapy for atherosclerosis. J Am Coll Cardiol. 49:2073–2080. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Yang N, Lin M, Wang BG, Zeng WY, He YF, Peng HY, Zeng J, Wu ZY and Zhong Y: Low level of low-density lipoprotein cholesterol is related with increased hemorrhagic transformation after acute ischemic cerebral infarction. Eur Rev Med Pharmacol Sci. 20:673–678. 2016.PubMed/NCBI

10 

Bazan HA, Smith TA, Donovan MJ and Sternbergh WC III: Future management of carotid stenosis: Role of urgent carotid interventions in the acutely symptomatic carotid patient and best medical therapy for asymptomatic carotid disease. Ochsner J. 14:608–615. 2014.PubMed/NCBI

11 

Bauzá A, Mooibroek TJ and Frontera A: Corrigendum: The bright future of unconventional σ/π-hole interactions. Chemphyschem. 16:31302015. View Article : Google Scholar : PubMed/NCBI

12 

Hermus L, Tielliu IF, Wallis de Vries BM, van den Dungen JJ and Zeebregts CJ: Imaging the vulnerable carotid artery plaque. Acta Chir Belg. 110:159–164. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A and Licata G: Atherosclerosis as an inflammatory disease. Curr Pharm Des. 18:4266–4288. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Azzurri A, Sow OY, Amedei A, Bah B, Diallo S, Peri G, Benagiano M, D'Elios MM, Mantovani A and Del Prete G: IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacteriumtuberculosis infection. Microbes Infect. 7:1–8. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Mairuhu AT, Peri G, Setiati TE, Hack CE, Koraka P, Soemantri A, Osterhaus AD, Brandjes DP, van der Meer JW, Mantovani A, et al: Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections. J Med Virol. 76:547–552. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B and Mantovani A: Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med. 29:1404–1407. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Sprong T, Peri G, Neeleman C, Mantovani A, Signorini S, van der Meer JW and van Deuren M: Pentraxin 3 and C-reactive protein in severe meningococcal disease. Shock. 31:28–32. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, et al: Long pentraxin 3: A marker of inflammation in untreated psoriatic patients. Int J Mol Med. 18:415–423. 2006.PubMed/NCBI

19 

Wang J, Yang Z, Liu C, Zhao Y and Chen Y: Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia. Int J Mol Med. 31:172–178. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yilmaz G, Arumugam TV, Stokes KY and Granger DN: Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation. 113:2105–2112. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen L, Yang Q, Ding R, Liu D and Chen Z: Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction. Exp Ther Med 16: 5253-5257, 2018.
APA
Chen, L., Yang, Q., Ding, R., Liu, D., & Chen, Z. (2018). Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction. Experimental and Therapeutic Medicine, 16, 5253-5257. https://doi.org/10.3892/etm.2018.6868
MLA
Chen, L., Yang, Q., Ding, R., Liu, D., Chen, Z."Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction". Experimental and Therapeutic Medicine 16.6 (2018): 5253-5257.
Chicago
Chen, L., Yang, Q., Ding, R., Liu, D., Chen, Z."Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5253-5257. https://doi.org/10.3892/etm.2018.6868
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Yang Q, Ding R, Liu D and Chen Z: Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction. Exp Ther Med 16: 5253-5257, 2018.
APA
Chen, L., Yang, Q., Ding, R., Liu, D., & Chen, Z. (2018). Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction. Experimental and Therapeutic Medicine, 16, 5253-5257. https://doi.org/10.3892/etm.2018.6868
MLA
Chen, L., Yang, Q., Ding, R., Liu, D., Chen, Z."Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction". Experimental and Therapeutic Medicine 16.6 (2018): 5253-5257.
Chicago
Chen, L., Yang, Q., Ding, R., Liu, D., Chen, Z."Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP‑2 and MMP‑9 were associated with acute cerebral infarction". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5253-5257. https://doi.org/10.3892/etm.2018.6868
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team