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Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin

  • Authors:
    • Raluca Maria Popescu
    • Ciprian Ober
    • Bogdan Sevastre
    • Marian Taulescu
    • Mihai Negru
    • Iulia Melega
    • Sidonia Bogdan
    • Cristina Nicula
    • Ioan Coman
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Specialties, Faculty of General Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Clinical Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj‑Napoca, Romania, Paraclinical Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj‑Napoca, Romania
    Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 137-146
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/etm.2018.6904
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Abstract

The aim of the study was to identify if there is a connection between the time of administration of alpha‑blocker medication and cataract surgery complications. Furthermore, it was explored whether discontinuation of tamsulosin before cataract surgery influences the manifestations of intraoperative floppy iris syndrome in rats. An experimental study was conducted on 20 male Wistar rats aged 1.5‑2 years (body mean weight 357 g), which were divided into four equal groups: Group 1, under tamsulosin hydrochloride 0.4 mg/day for 2 months; group 2, without any treatment in the first month, followed by tamsulosin; group 3, under tamsulosin for 1 month, followed by 1 month without any treatment; and group 4, control. The pupillary diameter was assessed before instillation of 0.5% tropicamide (mydriatic and cycloplegic agent), after 1 or 2 h from instillation and postoperatively. Furthermore, pupil constriction during surgery, the presence of floppy iris and prolapse of the iris following the main incision and during serum injection were also assessed. Other analyzed features included iris rupture, posterior capsule tear, vitreous loss, lens fragments in the vitreous, suprachoroidal bleeding and corneal haze. The iris dilator muscle thickness and the posterior epithelium was measured using light microscopy. In the control group, the largest pupillary diameters were indicated and in group 1, the smallest pupillary diameters were revealed. Statistically significant differences were indicated between group 1 and 2 and group 3 and 4. Floppy iris, iris prolapse in the main incision and during serum injection appeared at maximum frequency for group 1 with continuous treatment and low frequency for the control group. Lens fragments in the vitreous were present in the groups 1‑3. Notably, intraoperative miosis had statistical relevance in group 1 and group 2. To conclude, the present findings suggested there is a clear connection between the time of administration of the alpha‑blocker medication and most cataract complications. The results indicated that discontinuation of tamsulosin for one month largely reduces the manifestations of intraoperative floppy iris syndrome in rats, which may suggest to change preoperative treatment for benign prostatic hypertrophy with another class of drugs that do not interact with the iris receptors.
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Copy and paste a formatted citation
Spandidos Publications style
Popescu RM, Ober C, Sevastre B, Taulescu M, Negru M, Melega I, Bogdan S, Nicula C and Coman I: Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin. Exp Ther Med 17: 137-146, 2019.
APA
Popescu, R.M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I. ... Coman, I. (2019). Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin. Experimental and Therapeutic Medicine, 17, 137-146. https://doi.org/10.3892/etm.2018.6904
MLA
Popescu, R. M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I., Bogdan, S., Nicula, C., Coman, I."Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin". Experimental and Therapeutic Medicine 17.1 (2019): 137-146.
Chicago
Popescu, R. M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I., Bogdan, S., Nicula, C., Coman, I."Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin". Experimental and Therapeutic Medicine 17, no. 1 (2019): 137-146. https://doi.org/10.3892/etm.2018.6904
Copy and paste a formatted citation
x
Spandidos Publications style
Popescu RM, Ober C, Sevastre B, Taulescu M, Negru M, Melega I, Bogdan S, Nicula C and Coman I: Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin. Exp Ther Med 17: 137-146, 2019.
APA
Popescu, R.M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I. ... Coman, I. (2019). Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin. Experimental and Therapeutic Medicine, 17, 137-146. https://doi.org/10.3892/etm.2018.6904
MLA
Popescu, R. M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I., Bogdan, S., Nicula, C., Coman, I."Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin". Experimental and Therapeutic Medicine 17.1 (2019): 137-146.
Chicago
Popescu, R. M., Ober, C., Sevastre, B., Taulescu, M., Negru, M., Melega, I., Bogdan, S., Nicula, C., Coman, I."Complications of cataract surgery in Wistar rats undergoing treatment with tamsulosin". Experimental and Therapeutic Medicine 17, no. 1 (2019): 137-146. https://doi.org/10.3892/etm.2018.6904
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