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Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children

  • Authors:
    • Chunxiang Li
    • Limin Zhu
    • Xiaolei Gong
    • Zhuoming Xu
    • Yujie Liu
    • Mingjie Zhang
    • Qing Cao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiac Intensive Care Unit, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China, Department of Infectious Disease, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 147-152
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/etm.2018.6905
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Abstract

The present study aimed to assess the usefulness of soluble triggering receptor expressed on myeloid cells 1 (sTREM‑1) in the diagnosis of ventilator‑associated pneumonia (VAP) in paediatric patients with congenital heart disease (CHD) following cardiac surgery. The current prospective study enrolled 48 patients with congenital heart diseases who were suspected of having VAP; these patients were undergoing cardiac surgery between August 2016 and October 2017 in the Cardiac Intensive Care Unit of Shanghai Children's Medical Center (Shanghai, China). A total of 31 patients were diagnosed with VAP using a polymerase chain reaction (PCR) assay, while 17 patients without VAP were designated as the Non‑VAP group. A bronchoscopy was performed and samples were collected for measurement on the day that VAP was diagnosed. The sTREM‑1 levels were measured in bronchoalveolar lavage fluid (BALF) and exhaled ventilator condensate (EVC). BALF specimens were also sent to the microbiology laboratory for PCR assays and quantitative culturing. The positive detection rate of bacteria using the PCR assay and traditional culture was 64.6% (31/48) and 39.6% (19/48). sTREM‑1 was significantly higher in the BALF (146.21 pg/ml vs. 118.06 pg/ml) and EVC (125.29 pg/ml vs. 120.48 pg/ml) of patients with VAP demonstrated compared with the patients without VAP. The findings suggest that the detection of sTREM‑1 in BALF and EVC samples may be useful for the diagnosis of VAP following heart surgery in children.
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1 

Guardia Camí MT, Jordan García I and Urrea Ayala M: Nosocomial infections in pediatric patients following cardiac surgery. An Pediatr (Barc). 69:34–38. 2008.(In Spanish). View Article : Google Scholar : PubMed/NCBI

2 

Roeleveld PP, Guijt D, Kuijper EJ, Hazekamp MG, de Wilde RB and de Jonge E: Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands. Intensive Care Med. 37:1656–1663. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Tarnok A and Schneider P: Pediatric cardiac surgery with cardiopulmonary bypass: Pathways contributing to transient systemic immune suppression. Shock. 16 Suppl 1:S24–S32. 2001. View Article : Google Scholar

4 

Bassetti M, Taramasso L, Giacobbe DR and Pelosi P: Management of ventilator-associated pneumonia: Epidemiology, diagnosis and antimicrobial therapy. Expert Rev Anti Infect Ther. 10:585–596. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Melsen WG, Rovers MM, Groenwold RH, Bergmans DC, Camus C, Bauer TT, Hanisch EW, Klarin B, Koeman M, Krueger WA, et al: Attributable mortality of ventilator-associated pneumonia: A meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis. 13:665–671. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Brix-Christensen V: The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children. Acta Anaesthesiol Scand. 45:671–679. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Venkatachalam V, Hendley JO and Willson DF: The diagnostic dilemma of ventilator-associated pneumonia in critically ill children. Pediatr Crit Care Med. 12:286–296. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Fabregas N, Ewig S, Torres A, El-Ebiary M, Ramirez J, de La Bellacasa JP, Bauer T and Cabello H: Clinical diagnosis of ventilator associated pneumonia revisited: Comparative validation using immediate post-mortem lung biopsies. Thorax. 54:867–873. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Pontrelli G, De Crescenzo F, Buzzetti R, Calò Carducci F, Jenkner A, Amodio D, De Luca M, Chiurchiu S, Davies EH, Simonetti A, et al: Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: A systematic review. Ital J Pediatr. 42:442016. View Article : Google Scholar : PubMed/NCBI

10 

Mazzucchelli I, Garofoli F, Ciardelli L, Borghesi A, Tzialla C, Di Comite A, Angelini M, Tinelli C, Merlini G and Stronati M: Diagnostic performance of triggering receptor expressed on myeloid cells-1 and CD64 index as markers of sepsis in preterm newborns. Pediatr Crit Care Med. 14:178–182. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Palazzo SJ, Simpson T and Schnapp LM: Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis. Dimens Crit Care Nurs. 31:1–6. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Determann RM, Millo JL, Gibot S, Korevaar JC, Vroom MB, van der Poll T, Garrard CS and Schultz MJ: Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med. 31:1495–1500. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Matsuno AK and Carlotti AP: Role of soluble triggering receptor expressed on myeloid cells-1 for diagnosing ventilator-associated pneumonia after cardiac surgery: An observational study. BMC Cardiovasc Disord. 13:1072013. View Article : Google Scholar : PubMed/NCBI

14 

Yu Y, Zhu C, Liu C, Gao Y, Yin R and Cao J: Diagnostic performance of soluble triggering receptor expressed on myeloid cells-1 in ventilator-associated pneumonia of patients with ischemic stroke. Can J Infect Dis Med Microbiol. 2017:95136902017. View Article : Google Scholar : PubMed/NCBI

15 

Murphy J, O' Rourke S, Corcoran M, O' Sullivan N, Cunney R and Drew R: Evaluation of the clinical utility of a real-time PCR assay for the diagnosis of streptococcus pneumoniae bacteremia in children: A retrospective diagnostic accuracy study. Pediatr Infect Dis J. 37:153–156. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Chen YS, Liu PY, Huang YF, Chen CS, Chiu LH, Huang NY, Hsieh KS and Chen YS: Comparison of diagnostic tools with multiplex polymerase chain reaction for pediatric lower respiratory tract infection: A single center study. J Microbiol Immunol Infect. 46:413–418. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ngo TT, Hoang VT, Tran TL, Trinh VS, Tran T, Dao TQ, Phan QH, Meyer CG and Le HS: Clinical utility of an optimised multiplex real-time PCR assay for the identification of pathogens causing sepsis in vietnamese patients. Int J Infect Dis. 67:122–128. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Jordana-Lluch E, Gimenez M, Quesada MD, Ausina V and Martro E: Improving the diagnosis of bloodstream infections: PCR coupled with mass spectrometry. Biomed Res Int. 2014:5012142014. View Article : Google Scholar : PubMed/NCBI

19 

Vutukuru MR, Sharma DK, Ragavendar MS, Schmolke S, Huang Y, Gumbrecht W and Mitra N: A rapid, highly sensitive and culture-free detection of pathogens from blood by positive enrichment. J Microbiol Methods. 131:105–109. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Du Rand IA, Barber PV, Goldring J, Lewis RA, Mandal S, Munavvar M, Rintoul RC, Shah PL, Singh S, Slade MG, et al: British thoracic society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults. Thorax. 66 Suppl 3:iii1–iii21. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Balakrishnan G, Aitchison T, Hallworth D and Morton NS: Prospective evaluation of the Paediatric Risk of Mortality (PRISM) score. Arch Dis Child. 67:196–200. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Mildh L, Pettilä V, Sairanen H and Rautiainen P: Predictive value of paediatric risk of mortality score and risk adjustment for congenital heart surgery score after paediatric open-heart surgery. Interact Cardiovasc Thorac Surg. 6:628–631. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lauzier F, Ruest A, Cook D, Dodek P, Albert M, Shorr AF, Day A, Jiang X and Heyland D: The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia. J Crit Care. 23:50–57. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Salehifar E, Tavakolian Arjmand S, Aliyali M, Abedi S, Sharifpour A, Alipour A, Ala S, Eslami G, Bozorgi F, Mahdavi MR and Walley KR: Role of C-reactive protein and tumor necrosis factor-alpha in differentiating between ventilator-associated pneumonia and systemic inflammatory response syndrome without infectious etiology. Tanaffos. 15:205–212. 2016.PubMed/NCBI

25 

Klompas M, Branson R, Eichenwald EC, Greene LR, Howell MD, Lee G, Magill SS, Maragakis LL, Priebe GP, Speck K, et al: Strategies to prevent ventilator-associated pneumonia in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 35 Suppl 2:S133–S154. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Chiu YH, Chen TJ, Chen CT and Lu CC: Positive blood cultures in pediatric emergency department patients: Epidemiological and clinical characteristics. Acta Paediatr Taiwan. 46:11–16. 2005.PubMed/NCBI

27 

Shin JH, Song SA, Kim MN, Lee NY, Kim EC, Kim S, Koo SH, Ryoo NH, Kim JS and Cho JH: Comprehensive analysis of blood culture performed at nine university hospitals in Korea. Korean J Lab Med. 31:101–106. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Schindler MB and Cox PN: A simple method of bronchoalveolar lavage. Anaesth Intensive Care. 22:66–68. 1994.PubMed/NCBI

29 

Siow WT, Koay ES, Lee CK, Lee HK, Ong V, Ngerng WJ, Lim HF, Tan A, Tang JW and Phua J: The use of polymerase chain reaction amplification for the detection of viruses and bacteria in severe community-acquired pneumonia. Respiration. 92:286–294. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Carrol ED, Mankhambo LA, Guiver M, Banda DL; IPD Study Group, ; Denis B, Dove W, Jeffers G, Molyneux EM, Molyneux ME, et al: PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia. PLoS One. 6:e210422011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li C, Zhu L, Gong X, Xu Z, Liu Y, Zhang M and Cao Q: Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children. Exp Ther Med 17: 147-152, 2019.
APA
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., & Cao, Q. (2019). Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children. Experimental and Therapeutic Medicine, 17, 147-152. https://doi.org/10.3892/etm.2018.6905
MLA
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., Cao, Q."Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children". Experimental and Therapeutic Medicine 17.1 (2019): 147-152.
Chicago
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., Cao, Q."Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children". Experimental and Therapeutic Medicine 17, no. 1 (2019): 147-152. https://doi.org/10.3892/etm.2018.6905
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Zhu L, Gong X, Xu Z, Liu Y, Zhang M and Cao Q: Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children. Exp Ther Med 17: 147-152, 2019.
APA
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., & Cao, Q. (2019). Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children. Experimental and Therapeutic Medicine, 17, 147-152. https://doi.org/10.3892/etm.2018.6905
MLA
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., Cao, Q."Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children". Experimental and Therapeutic Medicine 17.1 (2019): 147-152.
Chicago
Li, C., Zhu, L., Gong, X., Xu, Z., Liu, Y., Zhang, M., Cao, Q."Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children". Experimental and Therapeutic Medicine 17, no. 1 (2019): 147-152. https://doi.org/10.3892/etm.2018.6905
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