Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of propofol on human cholangiocarcinoma and the associated mechanisms 

  • Authors:
    • Zhuo Zhang
    • Mingcui Zang
    • Shuang Wang
    • Chunli Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreas Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 472-478
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/etm.2018.6908
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cholangiocarcinoma (CCA) is the most common type of biliary duct malignancy. Propofol is a fast‑acting intravenous anesthetic, which also exerts an anti‑cancer effect. The aim of the current study was to explore the effects of propofol on human CCA and the associated mechanisms in vitro. The results indicated that as concentration (0, 1, 5 and 10 µg/ml) of propofol and treatment time (24, 48 and 72 h) increased, the cell inhibition rate of human CCA QBC939 cells increased. Furthermore, treatment with various concentrations of propofol for 48 h resulted in a decrease in migration and invasion capacity in QBC939 cells. Propofol also induced the apoptosis of QBC939 cells and cell cycle arrest in G1 phase. Propofol treatment increased the expression level of Bax and decreased that of Bcl‑2. In addition, the effects of propofol on gene expression were evaluated, including Wnt3α, β‑catenin, Snail1 and c‑myc in the Wnt/β‑catenin signaling pathway. It was identified that as the concentration of propofol increased, the expression of these genes decreased. In conclusion, the current results indicate that propofol is a promising therapeutic agent for the treatment of CCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP, Rosenberg WM, Tait P, Taylor-Robinson SD, Thillainayagam AV, et al: Guidelines for the diagnosis and treatment of cholangiocarcinoma: An update. Gut. 61:1657–1669. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Blechacz B and Gores GJ: Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment. Hepatology. 48:308–321. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Shaib YH, Davila JA, Mcglynn K and El-Serag HB: Rising incidence of intrahepatic cholangiocarcinoma in the United States: A true increase? J Hepatol. 40:472–477. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Landis SH, Murray T, Bolden S and Wingo PA: Cancer statistics, 1998. Ca Cancer J Clin. 48:6–29. 2010. View Article : Google Scholar

5 

Wang Q, Du T and Lu C: Perioperative blood transfusion and the clinical outcomes of patients undergoing cholangiocarcinoma surgery: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 28:1233–1240. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, et al: Kupffer cell-derived Tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS. Cancer Cell. 31:771–789. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Rahnemai-Azar AA, Weisbrod AB, Dillhoff M, Schmidt C and Pawlik TM: Intrahepatic cholangiocarcinoma: Current management and emerging therapies. Expert Rev Gastroenterol Hepatol. 11:439–449. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Chen X, Wu Q, Sun P, Zhao Y, Zhu M and Miao C: Propofol disrupts aerobic glycolysis in colorectal cancer cells via inactivation of the NMDAR-CAMKII-ERK Pathway. Cell Physiol Biochem. 46:492–504. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Cockshott ID, Briggs LP, Douglas EJ and White M: Pharmacokinetics of propofol in female patients. Studies using single bolus injections. Br J Anaesth. 59:1103–1110. 1987. View Article : Google Scholar : PubMed/NCBI

10 

Buckley A, McQuaid S, Johnson P and Buggy DJ: Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: A pilot study. Br J Anaesth. 113:56–62. 2014. View Article : Google Scholar

11 

Zhang T, Fan Y, Liu K and Wang Y: Effects of different general anaesthetic techniques on immune responses in patients undergoing surgery for tongue cancer. Anaesth Intensive Care. 42:220–227. 2014.PubMed/NCBI

12 

Jaura AI, Flood G, Gallagher HC and Buggy DJ: Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: A pilot study. Br J Anaesth. 113:63–67. 2014. View Article : Google Scholar

13 

Ecimovic P, McHugh B, Murray D, Doran P and Buggy DJ: Effects of sevoflurane on breast cancer cell function in vitro. Anticancer Res. 33:4255–4260. 2013.PubMed/NCBI

14 

Kurosawa S and Kato M: Anesthetics, immune cells, and immune responses. J Anesth. 22:263–277. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Siddiqui RA, Zerouga M, Wu M, Wu M, Castillo A, Harvey K, Zaloga GP and Stillwell W: Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells. Breast Cancer Res. 7:R645–R654. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Wu KC, Yang ST, Hsia TC, Yang JS, Chiou SM, Lu CC, Wu RS and Chung JG: Suppression of cell invasion and migration by propofol are involved in down-regulating matrix metalloproteinase-2 and p38 MAPK signaling in A549 human lung adenocarcinoma epithelial cells. Anticancer Res. 32:4833–4842. 2012.PubMed/NCBI

17 

Qian J, Shen S, Chen W and Chen N: Propofol reversed Hypoxia-induced docetaxel resistance in prostate cancer cells by preventing epithelial-Mesenchymal transition by inhibiting hypoxia-Inducible factor 1α. Biomed Res Int. 2018:41742322018. View Article : Google Scholar : PubMed/NCBI

18 

Li Q, Zhang L, Han Y, Jiang Z and Wang Q: Propofol reduces MMPs expression by inhibiting NF-kB activity in human MDA-MB-231 cells. Biomed Pharmacother. 66:52–56. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Meng C, Song L, Wang J, Li D, Liu Y and Cui X: Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231. Oncol Rep. 37:841–848. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Huang X, Teng Y, Yang H and Ma J: Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF-κB signal. Braz J Med Biol Res. 49:e57172016. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2011. View Article : Google Scholar

22 

Liu XF, Tang K, Sui LL and Xu G: Cholangiocarcinoma: Present status and molecular aspects of diagnosis. Onco Res. 22:177–183. 2014. View Article : Google Scholar

23 

El Chafic AH, Dewitt J, Leblanc JK, El Hajj II, Cote G, House MG, Sherman S, McHenry L, Pitt HA, Johnson C, et al: Impact of preoperative endoscopic ultrasound-guided fine needle aspiration on postoperative recurrence and survival in cholangiocarcinoma patients. Endoscopy. 45:883–889. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Jeong S, Zheng B, Wang J, Chi J, Tong Y, Xia L, Xu N, Zhang J, Kong X, Gu J and Xia Q: Transarterial chemoembolization: A favorable postoperative management to improve prognosis of hepatitis B virus-associated intrahepatic cholangiocarcinoma after surgical resection. Int J Biol Sci. 13:1234–1241. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Kovalenko YA, Vishnevsky VA, Chzhao AV and Zharikov YO: New criteria of radical surgery and long-term outcomes of hilar cholangiocarcinomamanagement (Russian). Khirurgiia (Mosk). 4–11. 2018.PubMed/NCBI

26 

Yao D, Kunam VK and Li X: A review of the clinical diagnosis and therapy of cholangiocarcinoma. J Int Med Res. 42:3–16. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Deng F, Ouyang M, Wang X, Yao X, Chen Y, Tao T, Sun X, Xu L, Tang J and Zhao L: Differential role of intravenous anesthetics in colorectal cancer progression: Implications for clinical application. Oncotarget. 7:77087–77095. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Ecimovic P, Murray D, Doran P and Buggy DJ: Propofol and bupivacaine in breast cancer cell function in vitro-role of the NET1 gene. Anticancer Res. 34:1321–1331. 2014.PubMed/NCBI

29 

Peng Z and Zhang Y: Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation of microRNA-451 and MMP-2 expression. Genet Mol Res. 15:2016. View Article : Google Scholar

30 

Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y and Nakamura H: Intravenous anaesthetic, propofol inhibits invasion of cancer cells. Cancer Lett. 184:165–170. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Chen X, Wu Q, You L, Chen S, Zhu M and Miao C: Propofol attenuates pancreatic cancer malignant potential via inhibition of NMDA receptor. Eur J Pharmacol. 795:150–159. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Chen X, Lu P, Chen L, Yang SJ, Shen HY, Yu DD, Zhang XH, Zhong SL, Zhao JH and Tang JH: Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer. Tumour Biol. 36:8259–8266. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Xu YJ, Li SY, Cheng Q, Chen WK, Wang SL, Ren Y and Miao CH: Effects of anaesthesia on proliferation, invasion and apoptosis of LoVo colon cancer cells in vitro. Anaesthesia. 71:147–154. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Wang ZT, Gong hY, Zheng F, Liu DJ and Yue XQ: Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression. Genet Mol Res. 14:8117–8124. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhang D, Zhou XH, Zhang J, Zhou YX, Ying J, Wu GQ and Qian JH: Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer. Biochem Biophys Res Commun. 468:561–567. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L, Wang N, Zhou S, Ye W, Jing G and Zshang M: Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2. J Exp Clin Cancer Res. 31:662012. View Article : Google Scholar : PubMed/NCBI

37 

Liu Z, Zhang J, Hong G, Quan J, Zhang L and Yu M: Propofol inhibits growth and invasion of pancreatic cancer cells through regulation of the miR-21/Slug signaling pathway. Am J Transl Res. 8:4120–4133. 2016.PubMed/NCBI

38 

Guo Q, Shen S, Liao M, Lian P and Wang X: NGX6 inhibits cell invasion and adhesion through suppression of Wnt/β-catenin signal pathway in colon cancer. Acta Biochim Biophys Sin (Shanghai). 42:450–456. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Mohammed MK, Shao C, Wang J, Wei Q, Wang X, Collier Z, Tang S, Liu H, Zhang F, Huang J, et al: Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis. 3:11–40. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Zang M, Wang S and Wang C: Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Exp Ther Med 17: 472-478, 2019.
APA
Zhang, Z., Zang, M., Wang, S., & Wang, C. (2019). Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Experimental and Therapeutic Medicine, 17, 472-478. https://doi.org/10.3892/etm.2018.6908
MLA
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17.1 (2019): 472-478.
Chicago
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17, no. 1 (2019): 472-478. https://doi.org/10.3892/etm.2018.6908
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Zang M, Wang S and Wang C: Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Exp Ther Med 17: 472-478, 2019.
APA
Zhang, Z., Zang, M., Wang, S., & Wang, C. (2019). Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Experimental and Therapeutic Medicine, 17, 472-478. https://doi.org/10.3892/etm.2018.6908
MLA
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17.1 (2019): 472-478.
Chicago
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17, no. 1 (2019): 472-478. https://doi.org/10.3892/etm.2018.6908
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team