Effects of propofol on human cholangiocarcinoma and the associated mechanisms 

  • Authors:
    • Zhuo Zhang
    • Mingcui Zang
    • Shuang Wang
    • Chunli Wang
  • View Affiliations

  • Published online on: October 31, 2018     https://doi.org/10.3892/etm.2018.6908
  • Pages: 472-478
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Abstract

Cholangiocarcinoma (CCA) is the most common type of biliary duct malignancy. Propofol is a fast‑acting intravenous anesthetic, which also exerts an anti‑cancer effect. The aim of the current study was to explore the effects of propofol on human CCA and the associated mechanisms in vitro. The results indicated that as concentration (0, 1, 5 and 10 µg/ml) of propofol and treatment time (24, 48 and 72 h) increased, the cell inhibition rate of human CCA QBC939 cells increased. Furthermore, treatment with various concentrations of propofol for 48 h resulted in a decrease in migration and invasion capacity in QBC939 cells. Propofol also induced the apoptosis of QBC939 cells and cell cycle arrest in G1 phase. Propofol treatment increased the expression level of Bax and decreased that of Bcl‑2. In addition, the effects of propofol on gene expression were evaluated, including Wnt3α, β‑catenin, Snail1 and c‑myc in the Wnt/β‑catenin signaling pathway. It was identified that as the concentration of propofol increased, the expression of these genes decreased. In conclusion, the current results indicate that propofol is a promising therapeutic agent for the treatment of CCA.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Z, Zang M, Wang S and Wang C: Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Exp Ther Med 17: 472-478, 2019
APA
Zhang, Z., Zang, M., Wang, S., & Wang, C. (2019). Effects of propofol on human cholangiocarcinoma and the associated mechanisms . Experimental and Therapeutic Medicine, 17, 472-478. https://doi.org/10.3892/etm.2018.6908
MLA
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17.1 (2019): 472-478.
Chicago
Zhang, Z., Zang, M., Wang, S., Wang, C."Effects of propofol on human cholangiocarcinoma and the associated mechanisms ". Experimental and Therapeutic Medicine 17, no. 1 (2019): 472-478. https://doi.org/10.3892/etm.2018.6908