Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood

Zhi,Ma; Zhang,Yanan; Liu,Lixia; Wang,Huizhi

doi:10.3892/etm.2018.6913

Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood

Authors:
- Ma Zhi
- Yanan Zhang
- Lixia Liu
- Huizhi Wang
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Affiliations: Department of Pediatric Surgery, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang, Heilongjiang 157011, P.R. China, Department of Obstetrics and Gynecology, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang, Heilongjiang 157011, P.R. China
Published online on: November 1, 2018 https://doi.org/10.3892/etm.2018.6913
Pages: 373-377
Copyright: © Zhi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diagnostic value of urinary retinol binding protein (RBP), albumin (ALB) and aquaporin-2 (AQP2) in neonatal hydronephrosis and their relationship with the expression of monocyte chemoattractant protein 1 (MCP-1) in the prenatal maternal peripheral blood was investigated. Forty-six child patients with hydronephrosis admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from December 2016 to November 2017 were selected as the observation group and the control included 46 normal newborn infants. The urinary RBP, ALB, AQP2 and the expression of MCP-1 in the prenatal maternal peripheral blood in the two groups were compared. The diagnostic value of the combination of urinary RBP, ALB and AQP2 for the neonatal hydronephrosis was accessed through the area under curve (AUC). The changes of urinary RBP, ALB and AQP2 of child patients were observed and the correlations between RBP, ALB, AQP2 and MCP-1 were analyzed. The concentrations of RBP and ALB in the observation group were obviously increased compared to those in the control group. The AQP2 concentration in the observation group was lower than that in the control group. In the observation group, the MCP-1 level in the prenatal maternal blood was significantly higher than that in the control group (P<0.05). After treatment, the concentration of RBP and ALB in the child patients were significantly decreased and AQP2 concentration was increased compared with that before treatment (P<0.05). The AUC of the diagnosis combining with RBP, ALB and AQP2 was 0.913. RBP and ALB were positively correlated to MCP-1 in the prenatal maternal peripheral blood and there was a negative correlation between AQP2 and MCP-1 (P<0.05). In conclusion, urinary RBP, ALB and AQP2 can be regarded as markers for the diagnosis of the neonatal hydronephrosis and they are also closely related to the MCP-1 level in the prenatal maternal peripheral blood.

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1	Masarwa I, Bahouth Z and Halachmi S: Giant congenital hydronephrosis obstructing the gastrointestinal system and the contralateral kidney in a new born. Urol Case Rep. 8:1–3. 2016. View Article : Google Scholar : PubMed/NCBI
2	Meyerholz DK and Hostetter SJ: Unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse. Vet Pathol. 42:496–498. 2005. View Article : Google Scholar : PubMed/NCBI
3	Al-Mashhadi A, Nevéus T, Stenberg A, Karanikas B, Persson AE, Carlström M and Wåhlin N: Surgical treatment reduces blood pressure in children with unilateral congenital hydronephrosis. J Pediatr Urol. 11:91.e1–91.e6. 2015. View Article : Google Scholar
4	Larson LM, Namaste SM, Williams AM, Engle-Stone R, Addo OY, Suchdev PS, Wirth JP, Temple V, Serdula M and Northrop-Clewes CA: Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 106 Suppl 1:390S–401S. 2017.PubMed/NCBI
5	Gong XZ, Zhou LF, Wang Q, Tang XC, Qian YR, Wang YR, Lu L and Zhou JJ: Effect of Chuanhuang No. 1 recipe on renal function and micro-inflammation in phase 3 chronic kidney disease patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 35:137–141. 2015.(In Chinese).
6	Cui X, Zhang J, Li Y, Sun Y, Cao J, Zhao M, Zhao Y, Zhao X, He Y and Han A: Effects of qili qiangxin capsule on AQP2, V2R, and AT1R in rats with chronic heart failure. Evid Based Complement Alternat Med. 2015:6394502015. View Article : Google Scholar : PubMed/NCBI
7	Satonaka H, Nagata D, Takahashi M, Kiyosue A, Myojo M, Fujita D, Ishimitsu T, Nagano T, Nagai R and Hirata Y: Involvement of P2Y12 receptor in vascular smooth muscle inflammatory changes via MCP-1 upregulation and monocyte adhesion. Am J Physiol Heart Circ Physiol. 308:H853–H861. 2015. View Article : Google Scholar : PubMed/NCBI
8	Santos AI, Violante L, Carmona S, Prata A, Rodrigues Victor M, Santos JG, Araújo Sequeira J, Alves M, Papoila AL and Piepsz A: Interobserver agreement on cortical tracer transit in 99mTc-MAG3 renography applied to congenital hydronephrosis. Nucl Med Commun. 38:124–128. 2017. View Article : Google Scholar : PubMed/NCBI
9	Harding LJ, Malone PS and Wellesley DG: Antenatal minimal hydronephrosis: Is its follow-up an unnecessary cause of concern? Prenat Diagn. 19:701–705. 1999. View Article : Google Scholar : PubMed/NCBI
10	Zhao Q, Yang Y, Wang C, Hou Y and Chen H: ATP5B and ETFB metabolic markers in children with congenital hydronephrosis. Mol Med Rep. 14:5111–5115. 2016. View Article : Google Scholar : PubMed/NCBI
11	Vemulakonda VM, Wilcox DT, Torok MR, Hou A, Campbell JB and Kempe A: Inter-rater reliability of postnatal ultrasound interpretation in infants with congenital hydronephrosis. Int Urol Nephrol. 47:1457–1461. 2015. View Article : Google Scholar : PubMed/NCBI
12	Xie J, Zhou Y, Gao W, Li Z, Xu Z and Zhou L: The relationship between amniotic fluid miRNAs and congenital obstructive nephropathy. Am J Transl Res. 9:1754–1763. 2017.PubMed/NCBI
13	Zabetian-Targhi F, Mahmoudi MJ, Rezaei N and Mahmoudi M: Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases. Adv Nutr. 6:748–762. 2015. View Article : Google Scholar : PubMed/NCBI
14	Gursoy AY, Aynaoglu G, Caglar GS and Soylemez F: Early second trimester retinol-binding protein-4 values in cases with or without gestational diabetes mellitus risk factors: A cross-sectional study. J Obstet Gynaecol Res. 41:55–61. 2015. View Article : Google Scholar : PubMed/NCBI
15	Woo HD, Chiu WA, Jo S and Kim J: Benchmark dose for urinary cadmium based on a marker of renal dysfunction: A meta-analysis. PLoS One. 10:e01266802015. View Article : Google Scholar : PubMed/NCBI
16	Cheema MU, Irsik DL, Wang Y, Miller-Little W, Hyndman KA, Marks ES, Frøkiær J, Boesen EI and Norregaard R: Estradiol regulates AQP2 expression in the collecting duct: A novel inhibitory role for estrogen receptor α. Am J Physiol Renal Physiol. 309:F305–F317. 2015. View Article : Google Scholar : PubMed/NCBI
17	Kristensen ML, Kierulf-Lassen C, Nielsen PM, Krag S, Birn H, Nejsum LN and Nørregaard R: Remote ischemic perconditioning attenuates ischemia/reperfusion-induced downregulation of AQP2 in rat kidney. Physiol Rep. 4:42016. View Article : Google Scholar
18	Arystarkhova E, Bouley R, Liu YB and Sweadner KJ: Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. PLoS One. 12:e01880062017. View Article : Google Scholar : PubMed/NCBI
19	Dekker Nitert M, Barrett HL, Denny KJ, McIntyre HD and Callaway LK; BAMBINO group, . Exercise in pregnancy does not alter gestational weight gain, MCP-1 or leptin in obese women. Aust N Z J Obstet Gynaecol. 55:27–33. 2015. View Article : Google Scholar : PubMed/NCBI
20	Adams Waldorf KM, Singh N, Mohan AR, Young RC, Ngo L, Das A, Tsai J, Bansal A, Paolella L, Herbert BR, et al: Uterine overdistention induces preterm labor mediated by inflammation: Observations in pregnant women and nonhuman primates. Am J Obstet Gynecol. 213:830.e1–830.e19. 2015. View Article : Google Scholar