Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization

Jiang,Xiaorui; Yang,Huiying; Huang,Botao; Lin,Guodong; Wang,Kai; Meng,Yongchun; Xue,Chunyu

doi:10.3892/etm.2018.6915

January-2019 Volume 17 Issue 1

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January-2019 Volume 17 Issue 1

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Article Open Access

Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization

Authors:
- Xiaorui Jiang
- Huiying Yang
- Botao Huang
- Guodong Lin
- Kai Wang
- Yongchun Meng
- Chunyu Xue
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Affiliations: Department of Orthopedics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Hepatology, Yantai Infectious Disease Hospital, Yantai, Shandong 264000, P.R. China, Department of Orthopedics, The Affiliated Yantai Hospital of Binzhou Medical University, Yantai, Shandong 264000, P.R. China, Emergency Department, Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China

Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 398-402
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Published online on: November 1, 2018

https://doi.org/10.3892/etm.2018.6915
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Abstract

Osteogenic efficiency of pre-vascularization and non-vascularization decalcified bone scaffolds in bone defect repair was investigated. Twenty-one Sprague‑Dawley (SD) mice were randomly assigned to three groups, and a bone defect area of ~1.5 cm in length in the thigh bone of the right posterior limbs of each mouse was made. Pre-vascularization decalcified bone scaffolds in vitro (group A) and non-treatment decalcified bone scaffolds (group B) were separately implanted. The defect vacancy was considered as the blank control (group C). Sampling was made 4 weeks after the operation for the histological examination, and then the osteogenic efficiency was observed by gross sample, imaging, hematoxylin and eosin staining and Masson's staining. When implanting pre-vascularization decalcified bone scaffolds in vitro, the scaffolding material showed an obvious absorption, and more new bone formations and abundant vascular proliferation were observed. In non-vascularization decalcified bone scaffolds implanting, absorption insufficiency of the scaffolding material was observed, fewer new-born bone formations were shown, and the new vessels were very small and few in number. The pre-vascularization decalcified bone scaffolds had a better osteogenic efficiency.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization

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