Open Access

Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization

  • Authors:
    • Xiaorui Jiang
    • Huiying Yang
    • Botao Huang
    • Guodong Lin
    • Kai Wang
    • Yongchun Meng
    • Chunyu Xue
  • View Affiliations

  • Published online on: November 1, 2018     https://doi.org/10.3892/etm.2018.6915
  • Pages: 398-402
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteogenic efficiency of pre-vascularization and non-vascularization decalcified bone scaffolds in bone defect repair was investigated. Twenty-one Sprague‑Dawley (SD) mice were randomly assigned to three groups, and a bone defect area of ~1.5 cm in length in the thigh bone of the right posterior limbs of each mouse was made. Pre-vascularization decalcified bone scaffolds in vitro (group A) and non-treatment decalcified bone scaffolds (group B) were separately implanted. The defect vacancy was considered as the blank control (group C). Sampling was made 4 weeks after the operation for the histological examination, and then the osteogenic efficiency was observed by gross sample, imaging, hematoxylin and eosin staining and Masson's staining. When implanting pre-vascularization decalcified bone scaffolds in vitro, the scaffolding material showed an obvious absorption, and more new bone formations and abundant vascular proliferation were observed. In non-vascularization decalcified bone scaffolds implanting, absorption insufficiency of the scaffolding material was observed, fewer new-born bone formations were shown, and the new vessels were very small and few in number. The pre-vascularization decalcified bone scaffolds had a better osteogenic efficiency.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jiang X, Yang H, Huang B, Lin G, Wang K, Meng Y and Xue C: Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization. Exp Ther Med 17: 398-402, 2019
APA
Jiang, X., Yang, H., Huang, B., Lin, G., Wang, K., Meng, Y., & Xue, C. (2019). Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization. Experimental and Therapeutic Medicine, 17, 398-402. https://doi.org/10.3892/etm.2018.6915
MLA
Jiang, X., Yang, H., Huang, B., Lin, G., Wang, K., Meng, Y., Xue, C."Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization". Experimental and Therapeutic Medicine 17.1 (2019): 398-402.
Chicago
Jiang, X., Yang, H., Huang, B., Lin, G., Wang, K., Meng, Y., Xue, C."Osteogenic efficiency in vivo of scaffolding material of prefabricated vascularization". Experimental and Therapeutic Medicine 17, no. 1 (2019): 398-402. https://doi.org/10.3892/etm.2018.6915