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International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy

  • Authors:
    • Lang‑Ping Tan
    • Yi‑Biao Ye
    • Yue Zhu
    • Zhi‑Long Gu
    • Qin‑Gui Chen
    • Miao‑Yun Long
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Sun Yat‑Sen Memorial Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510000, P.R. China, Department of Hepatobiliary Surgery, Sun Yat‑Sen Memorial Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510000, P.R. China, Intensive Care Unit, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China, Medical Intensive Care Unit, First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 323-331
    |
    Published online on: November 6, 2018
       https://doi.org/10.3892/etm.2018.6935
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Abstract

The association of the international normalized ratio (INR) with the long‑term clinical outcome of patients who undergo endarterectomy has not yet been studied. The present study therefore primarily aimed to evaluate the association of INR on admission with the 90‑day mortality of critically ill patients who underwent endarterectomy during hospitalization. The Medical Information Mart for Intensive Care III database was queried for patients undergoing endarterectomy. The 90‑day mortality of patients was selected as a primary endpoint. Receiver‑operating characteristic (ROC) curves were plotted to present the accuracy of predictions. Kaplan‑Meier curves and multivariate Cox regression analysis were performed to analyse associations. Propensity score matching (PSM) was also conducted to reduce confounding bias. A total of 230 patients were included, with 36 90‑day non‑survivors. Patients with a high INR (≥1.5) on admission exhibited a higher 90‑day mortality than those with a low INR (<1.5; 29.09 vs. 11.43%; P=0.003). The ROC area under the curve value was 0.687 [95% confidence interval (CI), 0.571‑0.780]. Kaplan‑Meier plots identified divergence in survival between patients with different INR levels (log‑rank test, P=0.0013). The results of the multivariate Cox regression analysis indicated that a high INR level was significantly associated with 90‑day mortality (hazard ratio, 2.19; 95% CI, 1.08‑4.45; P=0.0305). Analysis of the PSM cohort presented similar results. In conclusion, the INR levels of critically ill patients who undergo endarterectomy may be used to stratify their risk of 90‑day mortality.
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Copy and paste a formatted citation
Spandidos Publications style
Tan LP, Ye YB, Zhu Y, Gu ZL, Chen QG and Long MY: International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Exp Ther Med 17: 323-331, 2019.
APA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., & Long, M. (2019). International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Experimental and Therapeutic Medicine, 17, 323-331. https://doi.org/10.3892/etm.2018.6935
MLA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17.1 (2019): 323-331.
Chicago
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17, no. 1 (2019): 323-331. https://doi.org/10.3892/etm.2018.6935
Copy and paste a formatted citation
x
Spandidos Publications style
Tan LP, Ye YB, Zhu Y, Gu ZL, Chen QG and Long MY: International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Exp Ther Med 17: 323-331, 2019.
APA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., & Long, M. (2019). International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Experimental and Therapeutic Medicine, 17, 323-331. https://doi.org/10.3892/etm.2018.6935
MLA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17.1 (2019): 323-331.
Chicago
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17, no. 1 (2019): 323-331. https://doi.org/10.3892/etm.2018.6935
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