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International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy

  • Authors:
    • Lang‑Ping Tan
    • Yi‑Biao Ye
    • Yue Zhu
    • Zhi‑Long Gu
    • Qin‑Gui Chen
    • Miao‑Yun Long

  • View Affiliations

  • Published online on: November 6, 2018     https://doi.org/10.3892/etm.2018.6935
  • Pages: 323-331

  • Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association of the international normalized ratio (INR) with the long‑term clinical outcome of patients who undergo endarterectomy has not yet been studied. The present study therefore primarily aimed to evaluate the association of INR on admission with the 90‑day mortality of critically ill patients who underwent endarterectomy during hospitalization. The Medical Information Mart for Intensive Care III database was queried for patients undergoing endarterectomy. The 90‑day mortality of patients was selected as a primary endpoint. Receiver‑operating characteristic (ROC) curves were plotted to present the accuracy of predictions. Kaplan‑Meier curves and multivariate Cox regression analysis were performed to analyse associations. Propensity score matching (PSM) was also conducted to reduce confounding bias. A total of 230 patients were included, with 36 90‑day non‑survivors. Patients with a high INR (≥1.5) on admission exhibited a higher 90‑day mortality than those with a low INR (<1.5; 29.09 vs. 11.43%; P=0.003). The ROC area under the curve value was 0.687 [95% confidence interval (CI), 0.571‑0.780]. Kaplan‑Meier plots identified divergence in survival between patients with different INR levels (log‑rank test, P=0.0013). The results of the multivariate Cox regression analysis indicated that a high INR level was significantly associated with 90‑day mortality (hazard ratio, 2.19; 95% CI, 1.08‑4.45; P=0.0305). Analysis of the PSM cohort presented similar results. In conclusion, the INR levels of critically ill patients who undergo endarterectomy may be used to stratify their risk of 90‑day mortality.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tan LP, Ye YB, Zhu Y, Gu ZL, Chen QG and Long MY: International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Exp Ther Med 17: 323-331, 2019
APA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., & Long, M. (2019). International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy. Experimental and Therapeutic Medicine, 17, 323-331. https://doi.org/10.3892/etm.2018.6935
MLA
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17.1 (2019): 323-331.
Chicago
Tan, L., Ye, Y., Zhu, Y., Gu, Z., Chen, Q., Long, M."International normalized ratio on admission predicts the 90‑day mortality of critically ill patients undergoing endarterectomy". Experimental and Therapeutic Medicine 17, no. 1 (2019): 323-331. https://doi.org/10.3892/etm.2018.6935