Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure

  • Authors:
    • Yinghong Lu
    • Dan Wang
    • Xiaoli Yuan
    • Mengchao Wang
    • Zhihui Li
    • Xiaoqing Bao
    • Chengjia Zhang
    • Haiyun Jing
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology (V), Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 378-382
    |
    Published online on: November 12, 2018
       https://doi.org/10.3892/etm.2018.6957
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure (CHF) was investigated. Sixty rats were divided into the sham operation (n=20), the model (n=20) and the Qishen Yiqi dropping pill treatment group (n=20) using the random table method. The treatment group received administration of Qishen Yiqi dropping pills. The model and the sham operation group were given the same amount of normal saline. Within 24 h after the last administration, the rats were sacrificed. The myocardia were used for reverse transcription-polymerase chain reaction, western blot analysis and histological examination. In the sham operation group, cardiomyocytes were stained evenly and arranged neatly and densely with clear structures. In the model group, the cell morphology was fuzzy, the myocytes were hypertrophied, the nuclear pyknosis was fragmented, the arrangement was disordered, the intercellular space was narrowed, and the cytoplasm was missing. The apoptosis rates of cardiomyocytes in the model and Qishen Yiqi dropping pill treatment group were significantly higher than that in the sham operation group (P<0.05). The myocardial infarction areas in the model group and the Qishen Yiqi dropping pill treatment group were larger than that in the sham operation group (P<0.05). The expression levels of transforming growth factor-β1, mothers against decapentaplegic homolog 2 (Smad2), Smad3, and caspase-3 messenger ribonucleic acids and proteins in the model group and the Qishen Yiqi dropping pill treatment group were higher than those in the sham operation group (P<0.05). Qishen Yiqi dropping pills have an obvious myocardial protective effect on CHF rats, which may enhance the degree of myocardial fibrosis by inhibiting the TGF-β1/Smads pathway and improve cardiomyocyte apoptosis by suppressing the caspase-3 signaling pathway, thus protecting the myocardium.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Abraham WT, Stevenson LW, Bourge RC, Lindenfeld JA, Bauman JG and Adamson PB: CHAMPION Trial Study Group: Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: Complete follow-up results from the CHAMPION randomised trial. Lancet. 387:453–461. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Sharma A, Lavie CJ, Borer JS, Vallakati A, Goel S, Lopez-Jimenez F, Arbab-Zadeh A, Mukherjee D and Lazar JM: Meta-analysis of the relation of body mass index to all-cause and cardiovascular mortality and hospitalization in patients with chronic heart failure. Am J Cardiol. 115:1428–1434. 2015. View Article : Google Scholar : PubMed/NCBI

3 

JianXin C, Xue X, ZhongFeng L, Kuo G, FeiLong Z, ZhiHong L, Xian W and HongCai S: Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia. Sci Rep. 6:243832016. View Article : Google Scholar : PubMed/NCBI

4 

Satake H, Fukuda K, Sakata Y, Miyata S, Nakano M, Kondo M, Hasebe Y, Segawa M and Shimokawa H: CHART-2 Investigators: Current status of primary prevention of sudden cardiac death with implantable cardioverter defibrillator in patients with chronic heart failure - A report from the CHART-2 Study. Circ J. 79:381–390. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Troughton RW, Frampton CM, Brunner-La Rocca HP, Pfisterer M, Eurlings LW, Erntell H, Persson H, O'Connor CM, Moertl D, Karlström P, et al: Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: An individual patient meta-analysis. Eur Heart J. 35:1559–1567. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Gaggin HK, Szymonifka J, Bhardwaj A, Belcher A, De Berardinis B, Motiwala S, Wang TJ and Januzzi JL Jr: Head-to-head comparison of serial soluble ST2, growth differentiation factor-15, and highly-sensitive troponin T measurements in patients with chronic heart failure. JACC Heart Fail. 2:65–72. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Arzt M, Woehrle H, Oldenburg O, Graml A, Suling A, Erdmann E, Teschler H and Wegscheider K: SchlaHF Investigators: prevalence and predictors of sleep-disordered breathing in patients with stable chronic heart failure: The SchlaHF Registry. JACC Heart Fail. 4:116–125. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yang Q and Cao Y: Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 29:501–505. 2017.(In Chinese). PubMed/NCBI

9 

Yu FC, Xu YJ, Tong JY, Lu ZZ and Zhang XH: Therapeutic effects of Qishen Yiqi Dropping Pill on myocardial injury induced by chronic hypoxia in rats. Chin J Nat Med. 13:776–780. 2015.PubMed/NCBI

10 

Cui ZT, Wei WL, Liu M and Wang WJ: Effect of pretreatment with qishen yiqi dropping pills on right cardiac function of patients undergoing valve replacement. Zhongguo Zhong Yao Za Zhi. 39:916–919. 2014.(In Chinese). PubMed/NCBI

11 

Liu W, Gao FF, Li Q, Lv JW, Wang Y, Hu PC, Xiang QM and Wei L: Protective effect of astragalus polysaccharides on liver injury induced by several different chemotherapeutics in mice. Asian Pac J Cancer Prev. 15:10413–10420. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wang J, Lu L, Wang Y, Wu Y, Han J, Wang W, Li C and Tu P: Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation. J Ethnopharmacol. 176:375–384. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Wang Q, Li C, Lu L, Zhang Q, Zhu R and Wang W: A review of Chinese herbal medicine for the treatment of chronic heart failure. Curr Pharm Des. 23:5115–5124. 2017.PubMed/NCBI

14 

Zhao M, Zheng S, Yang J, Wu Y, Ren Y, Kong X, Li W and Xuan J: Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats. PLoS One. 10:e01213122015. View Article : Google Scholar : PubMed/NCBI

15 

Li S, Fan Q, He S, Tang T, Liao Y and Xie J: MicroRNA-21 negatively regulates Treg cells through a TGF-β1/Smad-independent pathway in patients with coronary heart disease. Cell Physiol Biochem. 37:866–878. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Wang D, Yuan X, Wang M, Li Z, Bao X, Zhang C and Jing H: Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure. Exp Ther Med 17: 378-382, 2019.
APA
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X. ... Jing, H. (2019). Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure. Experimental and Therapeutic Medicine, 17, 378-382. https://doi.org/10.3892/etm.2018.6957
MLA
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X., Zhang, C., Jing, H."Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure". Experimental and Therapeutic Medicine 17.1 (2019): 378-382.
Chicago
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X., Zhang, C., Jing, H."Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure". Experimental and Therapeutic Medicine 17, no. 1 (2019): 378-382. https://doi.org/10.3892/etm.2018.6957
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Wang D, Yuan X, Wang M, Li Z, Bao X, Zhang C and Jing H: Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure. Exp Ther Med 17: 378-382, 2019.
APA
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X. ... Jing, H. (2019). Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure. Experimental and Therapeutic Medicine, 17, 378-382. https://doi.org/10.3892/etm.2018.6957
MLA
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X., Zhang, C., Jing, H."Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure". Experimental and Therapeutic Medicine 17.1 (2019): 378-382.
Chicago
Lu, Y., Wang, D., Yuan, X., Wang, M., Li, Z., Bao, X., Zhang, C., Jing, H."Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure". Experimental and Therapeutic Medicine 17, no. 1 (2019): 378-382. https://doi.org/10.3892/etm.2018.6957
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team