Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study

  • Authors:
    • Youjing Zhang
    • Lu Zhao
    • Hongyang Li
    • Yanling Wang
  • View Affiliations

  • Published online on: November 14, 2018     https://doi.org/10.3892/etm.2018.6967
  • Pages: 453-458
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Abstract

Hypertensive retinopathy (HRP) is a clinical feature and systemic manifestation of hypertension. There have been few reports on the risk factors for hypertensive retinopathy in China. The aim of the present study was to describe risk factors associated with HRP in a population‑based sample of Chinese patients with hypertension in Beijing. The clinical data of 228 hypertensive patients was retrospectively studied, including 112 patients with retinopathy for the HRP group and 116 patients without retinopathy for the NO‑HRP group. Basic clinical data and plasma clinical indicators of the two groups were compared. Logistic regression models were used to assess risk factors associated with HRP. Duration of hypertension, smoking habits, family history of hypertension, plasma level of endothelin‑1 (ET‑1) and systolic and diastolic blood pressure were significantly increased in the HRP group compared with the NO‑HRP group (P<0.05). No significant differences were identified between the two groups for other factors. Logistic regression models indicated that hypertension duration (P<0.001, 95% CI: 0.962‑0.988) and ET‑1 level (P<0.001, 95% CI: 1.144‑1.278) were significantly associated with HRP. The diagnostic threshold of ET‑1 to diagnosis HRP was 43.5 ng/l. Of the factors studied, longer hypertension duration and elevated ET‑1 level were identified to be risk factors for HRP in patients with hypertension from Beijing. Detecting the plasma level of ET‑1 in patients with hypertension may be a useful diagnostic indicator for HRP.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Y, Zhao L, Li H and Wang Y: Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study. Exp Ther Med 17: 453-458, 2019
APA
Zhang, Y., Zhao, L., Li, H., & Wang, Y. (2019). Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study. Experimental and Therapeutic Medicine, 17, 453-458. https://doi.org/10.3892/etm.2018.6967
MLA
Zhang, Y., Zhao, L., Li, H., Wang, Y."Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study". Experimental and Therapeutic Medicine 17.1 (2019): 453-458.
Chicago
Zhang, Y., Zhao, L., Li, H., Wang, Y."Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study". Experimental and Therapeutic Medicine 17, no. 1 (2019): 453-458. https://doi.org/10.3892/etm.2018.6967