Bone marrow adipose amount influences vertebral bone strength

Zhu,Mo; Hao,Guangyu; Xing,Jianming; Hu,Su; Geng,Dechun; Zhang,Wen; Wang,Qianqian; Hu,Chunhong; Wang,Ximing

doi:10.3892/etm.2018.7003

Bone marrow adipose amount influences vertebral bone strength

Authors:
- Mo Zhu
- Guangyu Hao
- Jianming Xing
- Su Hu
- Dechun Geng
- Wen Zhang
- Qianqian Wang
- Chunhong Hu
- Ximing Wang
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Affiliations: Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Orthopedic, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
Published online on: November 22, 2018 https://doi.org/10.3892/etm.2018.7003
Pages: 689-694
Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Association of bone marrow adipose and microstructure with bone strength in osteoporotic rats using MR Dixon analysis and micro-CT was evaluated. A total of 40 female Sprague-Dawley rats (6-month-old) were divided randomly into sham-operated (SHAM, n=20) group and ovariectomized (OVX, n=20) group. Fat fraction (FF) was measured by two-point Dixon method with MR imaging at the baseline, 4th, 8th and 12th week, respectively. After sacrifice by anesthesia, the fifth lumbar vertebrae bone was sampled for micro-CT scanning. The biomechanical analysis was also performed. FF in osteoporotic rats significantly increases with time, which correlates with bone microstructure parameters. Compared with biomechanical test, FF showed negative correlation with break stress and elastic modulus. It also suggested that loss of bone mass was accompanied with the increase of adipose tissue content in vertebrae bone marrow. The impairment of bone strength leads to the risk of brittle fracture. In conclusion, the bone marrow adipose amount obtained by MR Dixon and microstructure by micro-CT correlates to bone strength in osteoporotic rats.

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