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Bone marrow adipose amount influences vertebral bone strength

  • Authors:
    • Mo Zhu
    • Guangyu Hao
    • Jianming Xing
    • Su Hu
    • Dechun Geng
    • Wen Zhang
    • Qianqian Wang
    • Chunhong Hu
    • Ximing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Orthopedic, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 689-694
    |
    Published online on: November 22, 2018
       https://doi.org/10.3892/etm.2018.7003
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Abstract

Association of bone marrow adipose and microstructure with bone strength in osteoporotic rats using MR Dixon analysis and micro-CT was evaluated. A total of 40 female Sprague-Dawley rats (6-month-old) were divided randomly into sham-operated (SHAM, n=20) group and ovariectomized (OVX, n=20) group. Fat fraction (FF) was measured by two-point Dixon method with MR imaging at the baseline, 4th, 8th and 12th week, respectively. After sacrifice by anesthesia, the fifth lumbar vertebrae bone was sampled for micro-CT scanning. The biomechanical analysis was also performed. FF in osteoporotic rats significantly increases with time, which correlates with bone microstructure parameters. Compared with biomechanical test, FF showed negative correlation with break stress and elastic modulus. It also suggested that loss of bone mass was accompanied with the increase of adipose tissue content in vertebrae bone marrow. The impairment of bone strength leads to the risk of brittle fracture. In conclusion, the bone marrow adipose amount obtained by MR Dixon and microstructure by micro-CT correlates to bone strength in osteoporotic rats.
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1 

Kageyama G: The diagnosis and treatment of osteoporosis. Rinsho Byori. 63:570–579. 2015.(In Japanese). PubMed/NCBI

2 

Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, Berger ML, Santora AC and Sherwood LM: Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the National Osteoporosis Risk Assessment. JAMA. 286:2815–2822. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Shen W, Chen J, Gantz M, Punyanitya M, Heymsfield SB, Gallagher D, Albu J, Engelson E, Kotler D, Pi-Sunyer X, et al: MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults. Eur J Clin Nutr. 66:983–988. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Li GW, Tang GY, Liu Y, Tang RB, Peng YF and Li W: MR spectroscopy and micro-CT in evaluation of osteoporosis model in rabbits: Comparison with histopathology. Eur Radiol. 22:923–929. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Li G, Xu Z, Chen Y, Chang S, Calimente H, Hu J and Wu D: Longitudinal assessment of marrow fat content using three-point Dixon technique in osteoporotic rabbits. Menopause. 23:1339–1344. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Bouxsein ML and Seeman E: Quantifying the material and structural determinants of bone strength. Best Pract Res Clin Rheumatol. 23:741–753. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Liu SP, Liao EY, Chen J, Yang SM, Li JW, Sheng ZF, Mo H, Wu XP, Yao L and Dai RC: Effects of methylprednisolone on bone mineral density and microarchitecture of trabecular bones in rats with administration time and assessed by micro-computed tomography. Acta Radiol. 50:93–100. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhu CT, Li T, Zhang P, Zou M, Guo Q and Qu XW: Beneficial effects of low-level laser irradiation on senile osteoporosis in rats. Eur Rev Med Pharmacol Sci. 21:5230–5238. 2017.PubMed/NCBI

9 

Dai QG, Zhang P, Wu YQ, Ma XH, Pang J, Jiang LY and Fang B: Ovariectomy induces osteoporosis in the maxillary alveolar bone: An in vivo micro-CT and histomorphometric analysis in rats. Oral Dis. 20:514–520. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Gatti V, Azoulay EM and Fritton SP: Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone. J Biomech. 66:127–136. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Minematsu A, Hanaoka T, Takeshita D, Takada Y, Okuda S, Imagita H and Sakata S: Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats. J Musculoskelet Neuronal Interact. 17:433–443. 2017.PubMed/NCBI

12 

Di Iorgi N, Rosol M, Mittelman SD and Gilsanz V: Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults. J Clin Endocrinol Metab. 93:2281–2286. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Shen W, Chen J, Punyanitya M, Shapses S, Heshka S and Heymsfield SB: MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int. 18:641–647. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Rahman S, Lu Y, Czernik PJ, Rosen CJ, Enerback S and Lecka-Czernik B: Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton. Endocrinology. 154:2687–2701. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Fanucci E, Manenti G, Masala S, Laviani F, Di Costanzo G, Ludovici A, Cozzolino V, Floris R and Simonetti G: Multiparameter characterisation of vertebral osteoporosis with 3-T MR. Radiol Med (Torino). 112:208–223. 2007. View Article : Google Scholar

16 

Hatipoglu HG, Selvi A, Ciliz D and Yuksel E: Quantitative and diffusion MR imaging as a new method to assess osteoporosis. AJNR Am J Neuroradiol. 28:1934–1937. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Hardouin P, Pansini V and Cortet B: Bone marrow fat. Joint Bone Spine. 81:313–319. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Tewari D, Khan MP, Sagar N, China SP, Singh AK, Kheruka SC, Barai S, Tewari MC, Nagar GK, Vishwakarma AL, et al: Ovariectomized rats with established osteopenia have diminished mesenchymal stem cells in the bone marrow and impaired homing, osteoinduction and bone regeneration at the fracture site. Stem Cell Rev. 11:309–321. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Ocarino NM, Boeloni JN, Jorgetti V, Gomes DA, Goes AM and Serakides R: Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats. Connect Tissue Res. 51:426–433. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Veronesi F, Torricelli P, Borsari V, Tschon M, Rimondini L and Fini M: Mesenchymal stem cells in the aging and osteoporotic population. Crit Rev Eukaryot Gene Expr. 21:363–377. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu M, Hao G, Xing J, Hu S, Geng D, Zhang W, Wang Q, Hu C and Wang X: Bone marrow adipose amount influences vertebral bone strength. Exp Ther Med 17: 689-694, 2019.
APA
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W. ... Wang, X. (2019). Bone marrow adipose amount influences vertebral bone strength. Experimental and Therapeutic Medicine, 17, 689-694. https://doi.org/10.3892/etm.2018.7003
MLA
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W., Wang, Q., Hu, C., Wang, X."Bone marrow adipose amount influences vertebral bone strength". Experimental and Therapeutic Medicine 17.1 (2019): 689-694.
Chicago
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W., Wang, Q., Hu, C., Wang, X."Bone marrow adipose amount influences vertebral bone strength". Experimental and Therapeutic Medicine 17, no. 1 (2019): 689-694. https://doi.org/10.3892/etm.2018.7003
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu M, Hao G, Xing J, Hu S, Geng D, Zhang W, Wang Q, Hu C and Wang X: Bone marrow adipose amount influences vertebral bone strength. Exp Ther Med 17: 689-694, 2019.
APA
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W. ... Wang, X. (2019). Bone marrow adipose amount influences vertebral bone strength. Experimental and Therapeutic Medicine, 17, 689-694. https://doi.org/10.3892/etm.2018.7003
MLA
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W., Wang, Q., Hu, C., Wang, X."Bone marrow adipose amount influences vertebral bone strength". Experimental and Therapeutic Medicine 17.1 (2019): 689-694.
Chicago
Zhu, M., Hao, G., Xing, J., Hu, S., Geng, D., Zhang, W., Wang, Q., Hu, C., Wang, X."Bone marrow adipose amount influences vertebral bone strength". Experimental and Therapeutic Medicine 17, no. 1 (2019): 689-694. https://doi.org/10.3892/etm.2018.7003
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