Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate

  • Authors:
    • Qian‑Qian Meng
    • Ning Pan
    • Jun‑Yu Xiong
    • Na Liu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, P.R. China
  • Pages: 943-947
    |
    Published online on: November 28, 2018
       https://doi.org/10.3892/etm.2018.7025
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this randomized controlled trial was to evaluate the effect of tranexamic acid (TXA) on postoperative blood loss during transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH). A total of 60 patients with BPH and undergoing TURP were randomized into TXA and control groups. Patients were intravenously administered 1 g TXA or placebo (0.9% sodium chloride solution), respectively, after the induction of anesthesia for TURP. Intraoperative and postoperative bladder irrigation volumes and blood loss volumes were compared between the two groups. Coagulation function (measured by prothrombin, activated partial thromboplastin and thrombin time and fibrinogen levels) was measured before the operation and at 4 h post‑operation. Complications from thromboembolic events, such as lower‑limb and pulmonary embolisms, were also noted. The TXA group had significantly decreased blood loss intraoperatively and at 4 h postoperatively compared with the control group (P<0.05). The 24 h postoperative blood loss and coagulation function of the two groups were not significantly different. No thromboembolic events or other complications occurred in either group. In conclusion, a preoperative single dose of TXA was indicated to reduce perioperative blood loss in TURP without a notable increase in thrombosis risk.
View Figures
View References

1 

Hahn RG: Fluid absorption in endoscopic surgery. Br JAnaesth. 96:8–20. 2006. View Article : Google Scholar

2 

Crescenti A, Borghi G, Bignami E, Bertarelli G, Landoni G, Casiraghi GM, Briganti A, Montorsi F, Rigatti P and Zangrillo A: Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: Double blind, randomized, placebo controlled trial. BMJ. 343:d57012011. View Article : Google Scholar : PubMed/NCBI

3 

de Médicis É: From the Journal archives: Complications of transurethral prostatic surgery: Back to the future? Can J Anesth. 61:273–277. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Soliman SA, Wadie BS, Ibrahim el-HE and Shehab El-Dein AB: Rotoresection versus transurethral resection of the prostate: Short-term evaluation of a prospective randomized study. J Urol. 177:1036–1039. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Demirel I, Ozer AB, Bayar MK and Erhan OL: TURP syndrome and severe hyponatremia under general anaesthesia. BMJ Case Rep. 2012:bcr02012-006899. 2012. View Article : Google Scholar

6 

Wang Q, Liu J, Fan R, Chen Y, Yu H, Bi Y, Hua Z, Piao M, Guo M, Ren W and Xiang L: Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: A randomized controlled trial. Eur Spine J. 22:2035–2038. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Gautam PL, Katyal S, Yamin M and Singh A: Effect of tranexamic acid on blood loss and transfusion requirement in total knee replacement in the Indian population: A case series. Indian J Anaesth. 55:590–593. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ruel MA, Wang F, Bourke ME, Dupuis JY, Robblee JA, Keon WJ and Rubens FD: Is tranexamic acid safe in patients undergoing coronary endarterectomy? Ann Thorac Surg. 71:1508–1511. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Ramsay MAE: The use of antifibrinolytic agents results in a reduction in transfused blood products during liver transplantation. Liver Transpl Surg. 3:665–668. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J and Lim W: Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials. Thromb Res. 123:687–696. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Qiu SP, Wu RP, Gao X, Cai YB and Liang WB: Clinical study on tranexamic acid in hemostatic treatment after prostatectomy: A comparative multi-center randomized trial. Chin J Urol. 26:305–307. 2005.(In Chinese).

12 

Kumsar S, Dirim A, Toksöz S, Sağlam HS and Adsan O: Tranexamic acid decreases blood loss during transurethral resection of the prostate. Cent European J Urol. 64:156–158. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Rannikko A, Pétas A and Taari K: Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy. Urology. 64:955–958. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Nielsen JD, Gram J, Holm-Nielsen A, Fabrin K and Jespersen J: Post-operative blood loss after transurethral prostatectomy is dependent on in situ fibrnolysis. Br J Urol. 80:889–893. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Porte RJ and Leebeek FW: Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs. 62:2193–2211. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Dadure C, Sauter M, Bringuier S, Bigorre M, Raux O, Rochette A, Canaud N and Capdevila X: Intraoperafive tranexamie acid reduces blood transfusion in children undergoing craniosynostosis surgery: A randomized double-blind study. Anesthesiology. 114:856–861. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Abrishami A, Chung F and Wong J: Topical application of antifibrinolytic drugs for on-pump cardiac surgery: A systematic review and meta-analysis. Can J Anesth. 56:202–212. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Aravinthan T: Massive haematuria with clot retention: Management options. Sri Lanka J Surg. 30:18–19. 2012.

19 

May F, Günther M, Barba M, Fastenmeier K and Hartung R: Coagulating intermittent cutting (CIC) dramatically reduces blood loss intransurethral resection of the prostate: Report from a multicenter trial and identificition of resk groups. Eur Urol. 2:1042003. View Article : Google Scholar

20 

Kumar S, Randhawa MS, Ganesamoni R and Singh SK: Tranexamic acid reduces blood loss during percutaneous nephrolithotomy: A prospective randomized controlled study. J Urol. 189:1757–1761. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Sa-Ngasoongsong P, Channoom T, Kawinwonggowit V, Woratanarat P, Chanplakorn P, Wibulpolprasert B, Wongsak S, Udomsubpayakul U, Wechmongkolgorn S and Lekpittaya N: Postoperative blood loss reduction in computer-assisted surgery total knee replacement by low dose intra-articular tranexamic acid injection together with 2-hour clamp drain: A prospective triple-blinded randomized controlled trial. Orthopedic Rev (Pavia). 3:e122011. View Article : Google Scholar

22 

Breuer T, Martin K, Wilhelm M, Wiesner G, Schreiber C, Hess J, Lange R and Tassani P: The blood sparing effect and the safety of aprotinin compared with tranexamic acid in paediatric cardiac surgery. Eur J Cardiothorac Surg. 35:167–171. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Lowe GDO, Greer IA, Cooke TG, Dewar EP, Evans MJ, Forbes CD, Mollan RAB, Scurr JH and de Swiss M: Risk of prophylaxis for venous thromboembolism in hospital patients. Thromboembolic Risk Factors (THRIFT) Consensus Group BMJ. 305:567–574. 1992.

24 

Mohapatra S, Samantaray JC, Arulselvi S and Ghosh A: Disseminated intravascular coagulation following malaria due to Plasmodium vivax: A thromboelastography based study. Malar J. 12:3362013. View Article : Google Scholar : PubMed/NCBI

25 

Bolliger D and Tanaka KA: Roles of Thrombelastography and thromboelastometry for patient blood management in cardiac surgery. Transfus Med Rev. 27:213–220. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Toukh M, Siemens DR, Black A, Robb S, Leveridge M, Graham CH and Othman M: Thromboelastography identifies hypercoagulablilty and predicts thromboembolic complications in patients with prostate cancer. Thromb Res. 133:88–95. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Faraoni D, Cacheux C, Van AC, Ickx BE, Barvais L and Levy JH: Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: A pilot, prospective, randomised, controlled study. Eur J Anaesthesiol. 31:491–498. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Chakravarthy M, Muniraj G, Patil S, Suryaprakash S, Mitra S and Shivalingappa B: A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130/0.4) undergoing off pump coronary artery bypass surgery. Ann Card Anaesth. 15:105–110. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Murkin JM, Falter F, Granton J, Young B, Burt C and Chu M: High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 110:350–353. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Koster A and Schirmer U: Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotininera. Curr Opin Anaesthesiol. 24:92–97. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Bell D, Marasco S, Almeida A and Rowland M: Tranexamic acid in cardiac surgery and postoperative seizures: A case report series. Heart Surg Forum. 13:E257–E259. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Sharma V, Katznelson R, Jerath A, Garrido-Olivares L, Carroll J, Rao V, Wasowicz M and Djaiani G: The association between tranexamic acid and convulsive seizures after cardiac surgery: A multivariate analysis in 11 529 patients. Anaesthesia. 69:124–30. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Williams-Johnson JA, McDonald AH, Strachan GG and Williams EW: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) a randomised, placebo-controlled trial. West Indian Med J. 59:612–624. 2010.PubMed/NCBI

34 

Martin K, Knorr J, Breuer T, Gertler R, Macguill M, Lange R, Tassani P and Wiesner G: Seizures after open heart surgery: Comparison of ε-aminocaproic acid and tranexamic acid. J Cardiothorac Vasc Anesth. 25:20–25. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Martin K, Breuer T, Gertler R, Hapfelmeier A, Schreiber C, Lange R, Hess J and Wiesner G: Tranexamic acid versus ε-aminocaproic acid: Efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg. 39:892–897. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Meng QQ, Pan N, Xiong JY and Liu N: Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate. Exp Ther Med 17: 943-947, 2019.
APA
Meng, Q., Pan, N., Xiong, J., & Liu, N. (2019). Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate. Experimental and Therapeutic Medicine, 17, 943-947. https://doi.org/10.3892/etm.2018.7025
MLA
Meng, Q., Pan, N., Xiong, J., Liu, N."Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate". Experimental and Therapeutic Medicine 17.1 (2019): 943-947.
Chicago
Meng, Q., Pan, N., Xiong, J., Liu, N."Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate". Experimental and Therapeutic Medicine 17, no. 1 (2019): 943-947. https://doi.org/10.3892/etm.2018.7025
Copy and paste a formatted citation
x
Spandidos Publications style
Meng QQ, Pan N, Xiong JY and Liu N: Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate. Exp Ther Med 17: 943-947, 2019.
APA
Meng, Q., Pan, N., Xiong, J., & Liu, N. (2019). Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate. Experimental and Therapeutic Medicine, 17, 943-947. https://doi.org/10.3892/etm.2018.7025
MLA
Meng, Q., Pan, N., Xiong, J., Liu, N."Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate". Experimental and Therapeutic Medicine 17.1 (2019): 943-947.
Chicago
Meng, Q., Pan, N., Xiong, J., Liu, N."Tranexamic acid is beneficial for reducing perioperative blood loss in transurethral resection of the prostate". Experimental and Therapeutic Medicine 17, no. 1 (2019): 943-947. https://doi.org/10.3892/etm.2018.7025
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team