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TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway

  • Authors:
    • Xingyu Liu
    • Zhifeng Miao
    • Zhenning Wang
    • Tingting Zhao
    • Yingying Xu
    • Yongxi Song
    • Jinyu Huang
    • Junyan Zhang
    • Hao Xu
    • Jianhua Wu
    • Huimian Xu
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 723-729
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    Published online on: November 28, 2018
       https://doi.org/10.3892/etm.2018.7028
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Abstract

The present study aimed to clarify the clinical significance and biological effects of T‑box (TBX)2 and its potential mechanism in gastric cancer (GC). TBX2 protein expression levels in human GC tissues were investigated using immunohistochemistry, and it was demonstrated that TBX2 was overexpressed in 55.9% (90/161) GC samples. TBX2 overexpression correlated with tumor invasion, advanced tumor node metastasis stage and presence of lymph node metastasis. In addition, TBX2 correlated with poor patient survival. To investigate the effect of TBX2 on biological behaviors, TBX2 plasmid transfection was performed in SGC‑7901 cells and TBX2 small interfering RNA knockdown was carried out in BGC‑823 cells. MTT and matrigel invasion assays demonstrated that TBX2 overexpression promoted proliferation and invasion, whereas TBX2 depletion inhibited proliferation and invasion. TBX2 overexpression also promoted epithelial‑mesenchymal transition by downregulating E‑cadherin and upregulating N‑cadherin. TBX2 overexpression also upregulated matrix metalloproteinase (MMP)2, MMP9, cyclin E and phosphorylated‑extracellular signal regulated kinase levels, however downregulated p21. In conclusion, TBX2 may serve as an effective predictor and therapeutic target in human GC.
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1 

Castro C, Peleteiro B, Bento MJ and Lunet N: Trends in gastric and esophageal cancer incidence in northern Portugal (1994–2009) by subsite and histology and predictions for 2015. Tumori. 103:155–163. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Leylabadlo HE, Kafil HS and Yousefi M: Gastric cancer mortality in a high-incidence area (Ardabil Province, Northwest Iran): What risk factors are causative? Eur J Cancer Prev. 25:573–574. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Yoon SB, Park JM, Lim CH, Kim JS, Cho YK, Lee BI, Lee IS, Kim SW and Choi MG: Incidence of gastric cancer after endoscopic resection of gastric adenoma. Gastrointest Endosc. 83:1176–1183. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Nicolas C, Sylvain M, Come L, Jean F, Anne-Marie B and Valerie J: Trends in gastric cancer incidence: A period and birth cohort analysis in a well-defined French population. Gastric Cancer. 19:508–514. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Wu H, Cai Z, Lu G, Cao S, Huang H, Jiang Y and Sun W: Impact of c-erbB-2 protein on 5-year survival rate of gastric cancer patients after surgery: A cohort study and meta-analysis. Tumori. 103:249–254. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Greenhill C: Gastric cancer. Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol. 12:1242015. View Article : Google Scholar : PubMed/NCBI

7 

Xie R, Wang X, Qi G, Wu Z, Wei R, Li P and Zhang D: DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition. Tumour Biol. 37:12049–12059. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Deng QJ, Xie LQ and Li H: Overexpressed MALAT1 promotes invasion and metastasis of gastric cancer cells via increasing EGFL7 expression. Life Sci. 157:38–44. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Ara H, Takagishi M, Enomoto A, Asai M, Ushida K, Asai N, Shimoyama Y, Kaibuchi K, Kodera Y and Takahashi M: Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis. Cancer Sci. 107:133–139. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Armas P, Margarit E, Mouguelar VS, Allende ML and Calcaterra NB: Beyond the binding site: In vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development. PLoS One. 8:e632342013. View Article : Google Scholar : PubMed/NCBI

11 

Miskolczi-McCallum CM, Scavetta RJ, Svendsen PC, Soanes KH and Brook WJ: The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Dev Biol. 278:459–472. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Takabatake Y, Takabatake T, Sasagawa S and Takeshima K: Conserved expression control and shared activity between cognate T-box genes TBX2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development. Dev Growth Differ. 44:257–271. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Takabatake Y, Takabatake T and Takeshima K: Conserved and divergent expression of T-box genes TBX2-Tbx5 in Xenopus. Mech Dev. 91:433–437. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Papaioannou VE: The T-box gene family: Emerging roles in development, stem cells and cancer. Development. 141:3819–3833. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Takahashi H: Functional evolution of T-box gene family on animal development. Tanpakushitsu Kakusan Koso. 46:1349–1357. 2001.(In Japanese). PubMed/NCBI

16 

Papaioannou VE and Silver LM: The T-box gene family. Bioessays. 20:9–19. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Yi CH, Terrett JA, Li QY, Ellington K, Packham EA, Armstrong-Buisseret L, McClure P, Slingsby T and Brook JD: Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18 and TBX19. Genomics. 55:10–20. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Brend T and Holley SA: Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box and Suppressor of Hairless proteins in the zebrafish segmentation clock. Dev Dyn. 238:2745–2759. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Butz NV, Gronostajski RM and Campbell CE: T-box proteins differentially activate the expression of the endogenous interferon gamma gene versus transfected reporter genes in non-immune cells. Gene. 377:130–139. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wan Z, Jiang D, Chen S, Jiao J, Ji L, Shah AS, Wei H, Yang X, Li X, Wang Y and Xiao J: T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12. Oncol Rep. 36:306–314. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Yu H, Liu BO, Liu A, Li K and Zhao H: T-box 2 expression predicts poor prognosis in gastric cancer. Oncol Lett. 10:1689–1693. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Chen S, Jiao J, Jiang D, Wan Z, Li L, Li K, Xu L, Zhou Z, Xu W and Xiao J: T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines. Tumour Biol. 36:5881–5890. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Abrahams A, Parker MI and Prince S: The T-box transcription factor TBX2: Its role in development and possible implication in cancer. IUBMB Life. 62:92–102. 2010.PubMed/NCBI

24 

Douglas NC and Papaioannou VE: The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 18:143–147. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Boskovic G and Niles RM: T-box binding protein type two (TBX2) is an immediate early gene target in retinoic-acid-treated B16 murine melanoma cells. Exp Cell Res. 295:281–289. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Liu WK, Jiang XY and Zhang ZX: Expression of PSCA, PIWIL1 and TBX2 in endometrial adenocarcinoma. Onkologie. 33:241–245. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Liu WK, Jiang XY and Zhang ZX: Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens. Arch Virol. 157:657–663. 2010. View Article : Google Scholar

28 

Han Y, Tu WW, Wen YG, Yan DW, Qiu GQ, Peng ZH and Zhou CZ: Increased expression of TBX2 is a novel independent prognostic biomarker of a worse outcome in colorectal cancer patients after curative surgery and a potential therapeutic target. Med Oncol. 30:6882013. View Article : Google Scholar : PubMed/NCBI

29 

Duo S, Tiao-Dong T, Lei Z, Wei W, Hong-Li S and Xian-Wei D: Expression and clinical significance of tbx2 in pancreatic cancer. Asian Pac J Cancer Prev. 10:118–122. 2009.PubMed/NCBI

30 

Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM and Kispert A: TBX2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 9:e10031892013. View Article : Google Scholar : PubMed/NCBI

31 

Bilican B and Goding CR: Cell cycle regulation of the T-box transcription factor tbx2. Exp Cell Res. 312:2358–2366. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Figueira RC, Gomes LR, Neto JS, Silva FC, Silva ID and Sogayar MC: Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential. BMC Cancer. 9:202009. View Article : Google Scholar : PubMed/NCBI

33 

Nutt JE, Durkan GC, Mellon JK and Lunec J: Matrix metalloproteinases (MMPs) in bladder cancer: The induction of MMP9 by epidermal growth factor and its detection in urine. BJU Int. 91:99–104. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Bachmeier BE, Nerlich AG, Lichtinghagen R and Sommerhoff CP: Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity. Anticancer Res. 21:3821–3828. 2001.PubMed/NCBI

35 

Roh MR, Zheng Z, Kim HS, Kwon JE, Jeung HC, Rha SY and Chung KY: Differential expression patterns of MMPs and their role in the invasion of epithelial premalignant tumors and invasive cutaneous squamous cell carcinoma. Exp Mol Pathol. 92:236–242. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Jung SA, Yang SK, Kim JS, Shim KN, Im SA, Myung SJ, Jung HY, Yu CS, Kim JC, Hong WS, et al: The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. Korean J Gastroenterol. 45:401–408. 2005.(In Korean). PubMed/NCBI

37 

Hotary KB, Yana I, Sabeh F, Li XY, Holmbeck K, Birkedal-Hansen H, Allen ED, Hiraoka N and Weiss SJ: Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes. J Exp Med. 195:295–308. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Matos ML, Lapyckyj L, Rosso M, Besso MJ, Mencucci MV, Briggiler CI, Giustina S, Furlong LI and Vazquez-Levin MH: Identification of a Novel Human E-cadherin splice variant and assessment of its effects upon EMT-related events. J Cell Physiol. 232:1368–1386. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Rogers CD, Saxena A and Bronner ME: Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. J Cell Biol. 203:835–847. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Prince S, Carreira S, Vance KW, Abrahams A and Goding CR: TBX2 directly represses the expression of the p21 (WAF1) cyclin-dependent kinase inhibitor. Cancer Res. 64:1669–1674. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Huang Y, Li Z, Zhong Q, Li G, Zhang Y and Huang Z: Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma. Int J Clin Exp Med. 7:5394–5402. 2014.PubMed/NCBI

42 

Zheng X, Wang Y, Liu B, Liu C, Liu D, Zhu J, Yang C, Yan J, Liao X, Meng X and Yang H: Bmi-1-shRNA inhibits the proliferation of lung adenocarcinoma cells by blocking the G1/S phase through decreasing cyclin D1 and increasing p21/p27 levels. Nucleic Acid Ther. 24:210–216. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Bartkova J, Lukas J, Strauss M and Bartek J: Cyclin D3: Requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation. Oncogene. 17:1027–1037. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Chen JR, Chatterjee B, Meyer R, Yu JC, Borke JL, Isales CM, Kirby ML, Lo CW and Bollag RJ: TBX2 represses expression of Connexin43 in osteoblastic-like cells. Calcif Tissue Int. 74:561–573. 2004. View Article : Google Scholar : PubMed/NCBI

45 

D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, et al: TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: A novel cancer-selective target pathway with therapeutic opportunities. Oncotarget. 5:1609–1620. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Nandana S, Tripathi M, Duan P, Chu CY, Mishra R, Liu C, Jin R, Yamashita H, Zayzafoon M, Bhowmick NA, et al: Bone metastasis of prostate cancer can be therapeutically targeted at the TBX2-WNT signaling axis. Cancer Res. 77:1331–1344. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Ma JW, Zhang Y, Ye JC, Li R, Wen YL, Huang JX and Zhong XY: Tetrandrine exerts a radiosensitization effect on human glioma through inhibiting proliferation by attenuating ERK phosphorylation. Biomol Ther (Seoul). 25:186–193. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Selvaraj P, Xiao L, Lee C, Murthy SR, Cawley NX, Lane M, Merchenthaler I, Ahn S and Loh YP: Neurotrophic Factor-α1: A key wnt-β-catenin dependent anti-proliferation factor and ERK-Sox9 activated inducer of embryonic neural stem cell differentiation to astrocytes in neurodevelopment. Stem Cells. 35:557–571. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Liu X, Tian S, Liu M, Jian L and Zhao L: Wogonin inhibits the proliferation and invasion and induces the apoptosis of HepG2 and Bel7402 HCC cells through NFκB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling. Int J Mol Med. 38:1250–1256. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Hamaoka Y, Negishi M and Katoh H: EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation. Cell Signal. 28:937–945. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Miao Z, Wang Z, Zhao T, Xu Y, Song Y, Huang J, Zhang J, Xu H, Wu J, Wu J, et al: TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway. Exp Ther Med 17: 723-729, 2019.
APA
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y. ... Xu, H. (2019). TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway. Experimental and Therapeutic Medicine, 17, 723-729. https://doi.org/10.3892/etm.2018.7028
MLA
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y., Huang, J., Zhang, J., Xu, H., Wu, J., Xu, H."TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway". Experimental and Therapeutic Medicine 17.1 (2019): 723-729.
Chicago
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y., Huang, J., Zhang, J., Xu, H., Wu, J., Xu, H."TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway". Experimental and Therapeutic Medicine 17, no. 1 (2019): 723-729. https://doi.org/10.3892/etm.2018.7028
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Miao Z, Wang Z, Zhao T, Xu Y, Song Y, Huang J, Zhang J, Xu H, Wu J, Wu J, et al: TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway. Exp Ther Med 17: 723-729, 2019.
APA
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y. ... Xu, H. (2019). TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway. Experimental and Therapeutic Medicine, 17, 723-729. https://doi.org/10.3892/etm.2018.7028
MLA
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y., Huang, J., Zhang, J., Xu, H., Wu, J., Xu, H."TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway". Experimental and Therapeutic Medicine 17.1 (2019): 723-729.
Chicago
Liu, X., Miao, Z., Wang, Z., Zhao, T., Xu, Y., Song, Y., Huang, J., Zhang, J., Xu, H., Wu, J., Xu, H."TBX2 overexpression promotes proliferation and invasion through epithelial‑mesenchymal transition and ERK signaling pathway". Experimental and Therapeutic Medicine 17, no. 1 (2019): 723-729. https://doi.org/10.3892/etm.2018.7028
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