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Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation

  • Authors:
    • Gaoyuan Wang
    • Junqiang Zhang
    • Yuan Fang
    • Wei Cao
    • Bin Xu
    • Xiaoyu Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230031, P.R. China, Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Blood Transfusion, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, P.R. China, Department of Histology and Embryology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 679-688
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    Published online on: November 30, 2018
       https://doi.org/10.3892/etm.2018.7036
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Abstract

Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro‑inflammatory cytokines may serve a key function in the development of the disease. 1,25‑Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit inflammation by acting on tolerogenic dendritic cells (tolDCs) in chronic inflammatory conditions. In the present study, DCs were isolated from peripheral blood mononuclear cells of patients with OA. DCs expressing high levels of co‑stimulatory molecules maintain a tolerogenic phenotype under stimulation with LPS, which promotes DC maturation to generate tolDCs. When vitD3/Dex were added in the current study, the tolDCs produced pro‑inflammatory cytokines, including low levels of tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑10, and high levels of transforming growth factor‑β. However, when vitD3/Dex were added to DCs without LPS stimulation, the levels of IL‑10 were high. DCs with LPS stimulation increased the percentage of T‑cells that produced IFN‑γ and IL‑17 and DCs with vitD3/Dex treatment alone increased the percentage of T‑cells that produced IL‑10 and FoxP3. However, those cytokines decrease in DCs co‑processed with LPS and vitD3/Dex. The IL‑10 release by the stimulated T cells was indicated to repress autologous T cell proliferation via soluble IL‑10 and cell‑cell contact. Furthermore, tolDCs and regulatory T cells suppressed matrix metalloproteinase (MMP)‑1 and MMP‑13 secretion by chondrocytes. Additionally, Akt and p38 mitogen‑activated protein kinase signaling were demonstrated to be involved in the regulatory effects of Dec and vitD3 in DCs. The present findings suggest a novel mechanism underlying the beneficial effects of tolDCs, particularly in association with the pathogenesis of OA.
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1 

Felson DT: Clinical practice. Osteoarthritis of the knee. N Engl J Med. 354:841–848. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Hügle T, Geurts J, Nüesch C, Müller-Gerbl M and Valderrabano V: Aging and osteoarthritis: An inevitable encounter? J Aging Res. 2012:9501922012. View Article : Google Scholar : PubMed/NCBI

3 

Pelletier JP, Martel-Pelletier J and Abramson SB: Osteoarthritis, an inflammatory disease: Potential implications for the selection of new therapeutic targets. Arthritis Rheum. 44:1237–1247. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Goode AP, Nelson AE, Kraus VB, Renner JB and Jordan JM: Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 25:1672–1679. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Delco ML, Bonnevie ED, Szeto HS, Bonassar LJ and Fortier LA: Mitoprotective therapy preserves chondrocyte viability and prevents cartilage degeneration in an ex vivo model of posttraumatic osteoarthritis. J Orthop Res. 2018. View Article : Google Scholar

6 

Roos EM and Arden NK: Strategies for the prevention of knee osteoarthritis. Nat Rev Rheumatol. 12:92–101. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hulet C, Menetrey J, Beaufils P, Chambat P, Djian P, Hardy P, Potel JF, Servien E and Seil R: French Arthroscopic Society (SFA): Clinical and radiographic results of arthroscopic partial lateral meniscectomies in stable knees with a minimum follow up of 20 years. Knee Surg Sports Traumatol Arthrosc. 23:225–231. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Verma P and Dalal K: ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis. J Cell Biochem. 112:3507–3514. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, Zhang L, Mi M, Chen D, Tong P and Jin H: Osthole promotes bone fracture healing through activation of BMP signaling in chondrocytes. Int J Biol Sci. 13:996–1007. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wang T and He C: Pro-inflammatorycytokines: The link between obesity andosteoarthritis. Cytokine Growth Factor Rev. S1359-6101(18)30119-9. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Chen YH, Yu Z, Fu L, Wang H, Chen X, Zhang C, Lv ZM and Xu DX: Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit. Sci Rep. 5:108712015. View Article : Google Scholar : PubMed/NCBI

13 

Anderson AE, Swan DJ, Sayers BL, Harry RA, Patterson AM, von Delwig A, Robinson JH, Isaacs JD and Hilkens CM: LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells. J Leukoc Biol. 85:243–250. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Feili-Hariri M, Dong X, Alber SM, Watkins SC, Salter RD and Morel PA: Immunotherapy of NOD mice with bone marrow-derived dendritic cells. Diabetes. 48:2300–2308. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Charbonnier LM, Van Duivenvoorde LM, Apparailly F, Cantos C, Han WG, Noël D, Duperray C, Huizinga TW, Toes RE, Jorgensen C and Louis-Plence P: Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells. J Immunol. 177:3806–3813. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lutz MB and Schuler G: Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol. 23:445–449. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Malemud CJ: Anticytokine therapy for osteoarthritis: Evidence to date. Drugs Aging. 27:95–115. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Volchenkov R, Karlsen M, Jonsson R and Appel S: Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scand J Immunol. 77:246–254. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Kimura A and Kishimoto T: IL-6: Regulator of Treg/Th17 balance. Eur J Immunol. 40:1830–1835. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Unger WW, Laban S, Kleijwegt FS, Van Der Slik AR and Roep BO: Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD-L1. Eur J Immunol. 39:3147–3159. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Xia CQ, Peng R, Beato F and Clare-Salzler MJ: Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity. Scand J Immunol. 62:45–54. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Dáňová K, Klapetková A, Kayserová J, Šedivá A, Špíšek R and Jelínková LP: NF-kB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment. Oncotarget. 6:14123–14138. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Yang J, Chen Q, Tian S, Song S, Liu F, Wang Q and Fu Z: The role of 1,25-dyhydroxyvitaminD3in mouse liver ischemia reperfusion injury: Regulation of autophagy through activation of MEK/ERK signaling and PTEN/PI3K/Akt/mTORC1 signaling. Am J Transl Res. 7:2630–2645. 2015.PubMed/NCBI

25 

Anderson AE, Sayers BL, Haniffa MA, Swan DJ, Diboll J, Wang XN, Isaacs JD and Hilkens CM: Differential regulation of naive and memory CD4+ T cells by alternatively activated dendritic cells. J Leukoc Biol. 84:124–133. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Banchereau J, Pascual V and Palucka AK: Autoimmunity through cytokine-induced dendritic cell activation. Immunity. 20:539–550. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM and Spector TD: Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum. 60:2037–2045. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J and Ding C: Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 18:1441–1447. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Barker T, Rogers VE, Henriksen VT, Aguirre D, Trawick RH, Rasmussen GL and Momberger NG: Serum cytokines are increased and circulating micronutrients are not altered in subjects with early compared to advanced knee osteoarthritis. Cytokine. 68:133–136. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chen B, Deng Y, Tan Y, Qin J and Chen LB: Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations. J Int Med Res. 42:138–144. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Su YP, Chen CN, Huang KC, Chang HI, Lee KC, Lo CM and Chang SF: Leptin induces MMP1/13 andADAMTS4 expressions through bone morphogenetic protein-2 autocrine effect in human chondrocytes. J Cell Biochem. 119:3716–3724. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Wieland HA, Michaelis M, Kirschbaum BJ and Rudolphi KA: Osteoarthritis-an untreatable disease? Nat Rev Drug Discov. 4:331–344. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ and Im HJ: A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 527:440–447. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Vincenti MP and Brinckerhoff CE: Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: Integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 4:157–164. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Emmer PM, van der Vlag J, Adema GJ and Hilbrands LB: Dendritic cells activated by lipopolysaccharide after dexamethasone treatment induce donor-specific allograft hyporesponsiveness. Transplantation. 81:1451–1459. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Ferreira GB, Kleijwegt FS, Waelkens E, Lage K, Nikolic T, Hansen DA, Workman CT, Roep BO, Overbergh L and Mathieu C: Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells. J Proteome Res. 11:941–971. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Bian Q, Wang YJ, Liu SF and Li YP: Osteoarthritis: Genetic factors, animal models, mechanisms, and therapies. Front Biosci. 4:74–100. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang G, Zhang J, Fang Y, Cao W, Xu B and Chen X: Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Exp Ther Med 17: 679-688, 2019.
APA
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., & Chen, X. (2019). Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Experimental and Therapeutic Medicine, 17, 679-688. https://doi.org/10.3892/etm.2018.7036
MLA
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., Chen, X."Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation". Experimental and Therapeutic Medicine 17.1 (2019): 679-688.
Chicago
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., Chen, X."Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation". Experimental and Therapeutic Medicine 17, no. 1 (2019): 679-688. https://doi.org/10.3892/etm.2018.7036
Copy and paste a formatted citation
x
Spandidos Publications style
Wang G, Zhang J, Fang Y, Cao W, Xu B and Chen X: Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Exp Ther Med 17: 679-688, 2019.
APA
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., & Chen, X. (2019). Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Experimental and Therapeutic Medicine, 17, 679-688. https://doi.org/10.3892/etm.2018.7036
MLA
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., Chen, X."Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation". Experimental and Therapeutic Medicine 17.1 (2019): 679-688.
Chicago
Wang, G., Zhang, J., Fang, Y., Cao, W., Xu, B., Chen, X."Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation". Experimental and Therapeutic Medicine 17, no. 1 (2019): 679-688. https://doi.org/10.3892/etm.2018.7036
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