Effects of liver function, insulin resistance and inflammatory factors on vascular endothelial dilation function and prognosis of coronary heart disease patients complicated with NAFLD

Wang,Bin; Li,Fang; Guo,Jingjing; Wang,Changmei; Xu,Dashuai; Li,Congcong

doi:10.3892/etm.2018.7043

Effects of liver function, insulin resistance and inflammatory factors on vascular endothelial dilation function and prognosis of coronary heart disease patients complicated with NAFLD

Authors:
- Bin Wang
- Fang Li
- Jingjing Guo
- Changmei Wang
- Dashuai Xu
- Congcong Li
View Affiliations

Affiliations: Department of Geriatrics, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, P.R. China
Published online on: December 4, 2018 https://doi.org/10.3892/etm.2018.7043
Pages: 1306-1311

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Effects of liver function, insulin resistance (IR) and inflammatory factors on vascular endothelial dilation function and prognosis of coronary heart disease (CHD) patients complicated with non‑alcoholic fatty liver disease (NAFLD) were investigated. A total of 80 patients with CHD treated in Jinan Central Hospital from October 2016 to July 2017 were randomly enrolled and divided into the NAFLD group (n=41) and the simple CHD group (n=39). The IR, the vascular endothelial dilation function and the related inflammatory factors were also detected, followed by statistical analysis. The level of high‑sensitivity C‑reactive protein (hs‑CRP), serum total bilirubin and alanine aminotransferase (ALT) levels and body mass index in the NAFLD group was decreased and the expression of tumor necrosis factor‑α was increased compared with that in the simple CHD group (P<0.05). There was a linearly positive correlation between ALT and brachial artery diameter in the NAFLD group (r=0.311, P<0.05). There was a correlation between homeostasis model assessment‑IR (HOMA‑IR) and HOMA‑β indexes and brachial artery diameter, hs‑CRP and brachial artery diameter in both groups (r=‑0.128, r=0.219, P<0.05). The HOMA indexes in the NAFLD group were increased compared with those in the simple CHD group (P<0.01). There were significant differences in the intima‑media thickness, number of carotid plaques and detection rate of carotid plaques (P<0.05). The risk of cardiovascular events within 10 years in the NAFLD group was increased compared with that in the simple CHD group. The differences of incidence of cardiovascular diseases (CVD)s were statistically significant (P<0.05). Therefore, The changes in liver function indexes, IR and related inflammatory factors in CHD patients complicated with NAFLD significantly affect the vascular endothelial dilation function, which also have some effects on the occurrence of CVDs.

View Figures

View References

1	Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD and Stein DT: Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol. 276:E977–E989. 1999.PubMed/NCBI
2	Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM and Hobbs HH: Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology. 40:1387–1395. 2004. View Article : Google Scholar : PubMed/NCBI
3	Day CP: Pathogenesis of steatohepatitis. Best Pract Res Clin Gastroenterol. 16:663–678. 2002. View Article : Google Scholar : PubMed/NCBI
4	Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M and Sanyal AJ: American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterologyh: The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 142:1592–1609. 2012. View Article : Google Scholar : PubMed/NCBI
5	Fracanzani AL, Valenti L, Bugianesi E, Andreoletti M, Colli A, Vanni E, Bertelli C, Fatta E, Bignamini D, Marchesini G, et al: Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology. 48:792–798. 2008. View Article : Google Scholar : PubMed/NCBI
6	Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Cornér A, Bergholm R and Yki-Järvinen H: Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care. 31:165–169. 2008. View Article : Google Scholar : PubMed/NCBI
7	Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, et al: Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology. 133:496–506. 2007. View Article : Google Scholar : PubMed/NCBI
8	Bellentani S, Saccoccio G, Masutti F, Crocè LS, Brandi G, Sasso F, Cristanini G and Tiribelli C: Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med. 132:112–117. 2000. View Article : Google Scholar : PubMed/NCBI
9	Bhatia LS, Curzen NP, Calder PC and Byrne CD: Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J. 33:1190–1200. 2012. View Article : Google Scholar : PubMed/NCBI
10	Sunny NE, Parks EJ, Browning JD and Burgess SC: Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 14:804–810. 2011. View Article : Google Scholar : PubMed/NCBI
11	Souza MR, Diniz MF, Medeiros-Filho JE and Araújo MS: Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 49:89–96. 2012. View Article : Google Scholar : PubMed/NCBI
12	Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, et al: European Atherosclerosis Society Consensus Panel: Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 32:1345–1361. 2011. View Article : Google Scholar : PubMed/NCBI
13	Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML and Clore JN: Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 120:1183–1192. 2001. View Article : Google Scholar : PubMed/NCBI
14	Yki-Järvinen H: Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. Dig Dis. 28:203–209. 2010. View Article : Google Scholar : PubMed/NCBI
15	Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, Okunade A and Klein S: Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA. 106:15430–15435. 2009. View Article : Google Scholar : PubMed/NCBI
16	Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, Ponti V, Pagano G, Ferrannini E and Rizzetto M: Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia. 48:634–642. 2005. View Article : Google Scholar : PubMed/NCBI
17	Wald D, Teucher B, Dinkel J, Kaaks R, Delorme S, Boeing H, Seidensaal K, Meinzer HP and Heimann T: Automatic quantification of subcutaneous and visceral adipose tissue from whole-body magnetic resonance images suitable for large cohort studies. J Magn Reson Imaging. 36:1421–1434. 2012. View Article : Google Scholar : PubMed/NCBI
18	Lomonaco R, Ortiz-Lopez C, Orsak B, Webb A, Hardies J, Darland C, Finch J, Gastaldelli A, Harrison S, Tio F, et al: Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology. 55:1389–1397. 2012. View Article : Google Scholar : PubMed/NCBI
19	Machado MV, Ferreira DM, Castro RE, Silvestre AR, Evangelista T, Coutinho J, Carepa F, Costa A, Rodrigues CM and Cortez-Pinto H: Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance. PLoS One. 7:e317382012. View Article : Google Scholar : PubMed/NCBI
20	Gastaldelli A: Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Res Clin Pract. 93 Suppl 1:S60–S65. 2011. View Article : Google Scholar : PubMed/NCBI