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Role of stress in modulation of skin neurogenic inflammation

  • Authors:
    • Ovidiu Grigore
    • Alexandra Ioana Mihailescu
    • Iulia Solomon
    • Daniel Boda
    • Constantin Caruntu
  • View Affiliations / Copyright

    Affiliations: Department of Applied Electronics and Information Engineering, Polytechnic University of Bucharest, 061071 Bucharest, Romania, Department of Medical Psychology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania, Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Prof. N. Paulescu’ National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania
    Copyright: © Grigore et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 997-1003
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    Published online on: December 5, 2018
       https://doi.org/10.3892/etm.2018.7058
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Abstract

There are complex interconnections between the nervous system and the skin highlighted by the impact of stress and neuroendocrine factors on various dermatological conditions. We investigated the influence of stress on skin neurogenic inflammation induced by capsaicin. A total of 31 healthy subjects were randomized into two groups: subjects in the stress group underwent a stress-inducing protocol and those in the control group were exposed to indifferent conditions. Subsequently, topical capsaicin cream was administered on the non-dominant anterior forearm of each subject from the two groups. The assessment of the local inflammatory reaction induced by capsaicin was performed by thermography at 25 and 40 min post-application. In both groups the inflammatory reaction induced by capsaicin was evidenced at 25 min and was maintained at 40 min post-application. However, at 40 min post-application the hyperthermal area was larger in subjects from the stress group, suggesting that stress exposure is associated with an amplification of the mechanisms involved in capsaicin-induced skin neurogenic inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Grigore O, Mihailescu AI, Solomon I, Boda D and Caruntu C: Role of stress in modulation of skin neurogenic inflammation. Exp Ther Med 17: 997-1003, 2019.
APA
Grigore, O., Mihailescu, A.I., Solomon, I., Boda, D., & Caruntu, C. (2019). Role of stress in modulation of skin neurogenic inflammation. Experimental and Therapeutic Medicine, 17, 997-1003. https://doi.org/10.3892/etm.2018.7058
MLA
Grigore, O., Mihailescu, A. I., Solomon, I., Boda, D., Caruntu, C."Role of stress in modulation of skin neurogenic inflammation". Experimental and Therapeutic Medicine 17.2 (2019): 997-1003.
Chicago
Grigore, O., Mihailescu, A. I., Solomon, I., Boda, D., Caruntu, C."Role of stress in modulation of skin neurogenic inflammation". Experimental and Therapeutic Medicine 17, no. 2 (2019): 997-1003. https://doi.org/10.3892/etm.2018.7058
Copy and paste a formatted citation
x
Spandidos Publications style
Grigore O, Mihailescu AI, Solomon I, Boda D and Caruntu C: Role of stress in modulation of skin neurogenic inflammation. Exp Ther Med 17: 997-1003, 2019.
APA
Grigore, O., Mihailescu, A.I., Solomon, I., Boda, D., & Caruntu, C. (2019). Role of stress in modulation of skin neurogenic inflammation. Experimental and Therapeutic Medicine, 17, 997-1003. https://doi.org/10.3892/etm.2018.7058
MLA
Grigore, O., Mihailescu, A. I., Solomon, I., Boda, D., Caruntu, C."Role of stress in modulation of skin neurogenic inflammation". Experimental and Therapeutic Medicine 17.2 (2019): 997-1003.
Chicago
Grigore, O., Mihailescu, A. I., Solomon, I., Boda, D., Caruntu, C."Role of stress in modulation of skin neurogenic inflammation". Experimental and Therapeutic Medicine 17, no. 2 (2019): 997-1003. https://doi.org/10.3892/etm.2018.7058
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