Role of stress in modulation of skin neurogenic inflammation

Grigore,Ovidiu; Mihailescu,Alexandra   Ioana; Solomon,Iulia; Boda,Daniel; Caruntu,Constantin

doi:10.3892/etm.2018.7058

Role of stress in modulation of skin neurogenic inflammation

Authors:
- Ovidiu Grigore
- Alexandra Ioana Mihailescu
- Iulia Solomon
- Daniel Boda
- Constantin Caruntu
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Affiliations: Department of Applied Electronics and Information Engineering, Polytechnic University of Bucharest, 061071 Bucharest, Romania, Department of Medical Psychology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania, Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Prof. N. Paulescu’ National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania
Published online on: December 5, 2018 https://doi.org/10.3892/etm.2018.7058
Pages: 997-1003
Copyright: © Grigore et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There are complex interconnections between the nervous system and the skin highlighted by the impact of stress and neuroendocrine factors on various dermatological conditions. We investigated the influence of stress on skin neurogenic inflammation induced by capsaicin. A total of 31 healthy subjects were randomized into two groups: subjects in the stress group underwent a stress-inducing protocol and those in the control group were exposed to indifferent conditions. Subsequently, topical capsaicin cream was administered on the non-dominant anterior forearm of each subject from the two groups. The assessment of the local inflammatory reaction induced by capsaicin was performed by thermography at 25 and 40 min post-application. In both groups the inflammatory reaction induced by capsaicin was evidenced at 25 min and was maintained at 40 min post-application. However, at 40 min post-application the hyperthermal area was larger in subjects from the stress group, suggesting that stress exposure is associated with an amplification of the mechanisms involved in capsaicin-induced skin neurogenic inflammation.

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1	Lander F, Friche C, Tornemand H, Andersen JH and Kirkeskov L: Can we enhance the ability to return to work among workers with stress-related disorders? BMC Public Health. 9:3722009. View Article : Google Scholar : PubMed/NCBI
2	Dhabhar FS and McEwen BS: Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci USA. 96:1059–1064. 1999. View Article : Google Scholar : PubMed/NCBI
3	Maddock C and Pariante CM: How does stress affect you? An overview of stress, immunity, depression and disease. Epidemiol Psichiatr Soc. 10:153–162. 2001. View Article : Google Scholar : PubMed/NCBI
4	Van Rhenen W, Blonk RW, van der Klink JJ, van Dijk FJ and Schaufeli WB: The effect of a cognitive and a physical stress-reducing programme on psychological complaints. Int Arch Occup Environ Health. 78:139–148. 2005. View Article : Google Scholar : PubMed/NCBI
5	Koo J and Lebwohl A: Psycho dermatology: The mind and skin connection. Am Fam Physician. 64:1873–1878. 2001.PubMed/NCBI
6	Arck P and Paus R: From the brain-skin connection: The neuroendocrine-immune misalliance of stress and itch. Neuroimmunomodulation. 13:347–356. 2006. View Article : Google Scholar : PubMed/NCBI
7	Tausk F, Elenkov I and Moynihan J: Psychoneuroimmunology. Dermatol Ther. 21:22–31. 2008. View Article : Google Scholar : PubMed/NCBI
8	Gupta MA and Gupta AK: Psychiatric and psychological co-morbidity in patients with dermatologic disorders: Epidemiology and management. Am J Clin Dermatol. 4:833–842. 2003. View Article : Google Scholar : PubMed/NCBI
9	Căruntu C, Grigore C, Căruntu A, Diaconeasa A and Boda D: The role of stress in skin diseases. Medicina Internă: Internal Medicine. 8:73–84. 2011.(In Romanian).
10	Căruntu C, Ghiță MA, Căruntu A and Boda D: The role of stress in the multifactorial etiopathogenesis of acne. Ro Med J. 58:98–101. 2011.
11	Surcel M, Constantin C, Caruntu C, Zurac S and Neagu M: Inflammatory cytokine pattern is sex-dependent in mouse cutaneous melanoma experimental model. J Immunol Res. 2017:92121342017. View Article : Google Scholar : PubMed/NCBI
12	Caruntu C, Mirica A, Rosca AE, Mirica R, Caruntu A, Tampa M, Matei C, Constantin C, Neagu M, Badarau AI, et al: The role of estrogens and estrogen receptors in melanoma development and progression. Acta Endo. 12:234–241. 2016. View Article : Google Scholar
13	Caruntu C, Boda D, Constantin C, Caruntu A and Neagu M: Catecholamines increase in vitro proliferation of murine B16F10 melanoma cells. Acta Endocrinologica (Bucharest). 10:545–558. 2014.
14	Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, et al: Neuroendocrine factors: The missing link in non-melanoma skin cancer (Review). Oncol Rep. 38:1327–1340. 2017. View Article : Google Scholar : PubMed/NCBI
15	Solomon I, Voiculescu VM, Caruntu C, Lupu M, Popa A, Ilie MA, Albulescu R, Caruntu A, Tanase C, Constantin C, et al: Neuroendocrine factors and head and neck squamous cell carcinoma: An affair to remember. Dis Markers. 2018:97878312018. View Article : Google Scholar : PubMed/NCBI
16	Zegarska B, Lelińska A and Tyrakowski T: Clinical and experimental aspects of cutaneous neurogenic inflammation. Pharmacol Rep. 58:13–21. 2006.PubMed/NCBI
17	Căruntu C, Boda D, Musat S, Căruntu A, Poenaru E, Calenic B, Savulescu-Fiedler I, Draghia A, Rotaru M and Badarau AI: Stress effects on cutaneous nociceptive nerve fibers and their neurons of origin in rats. Rom Biotechnol Lett. 19:9525–9538. 2014.
18	Filippi A, Caruntu C, Gheorghe RO, Deftu A, Amuzescu B and Ristoiu V: Catecholamines reduce transient receptor potential vanilloid type 1 desensitization in cultured dorsal root ganglia neurons. J Physiol Pharmacol. 67:843–850. 2016.PubMed/NCBI
19	Singh LK, Pang X, Alexacos N, Letourneau R and Theoharides TC: Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: A link to neurogenic skin disorders. Brain Behav Immun. 13:225–239. 1999. View Article : Google Scholar : PubMed/NCBI
20	Căruntu C, Boda D, Musat S, Căruntu A and Mandache E: Stress-induced mast cell activation in glabrous and hairy skin. Mediators Inflamm. 2014:1059502014. View Article : Google Scholar : PubMed/NCBI
21	Pavlovic S, Daniltchenko M, Tobin DJ, Hagen E, Hunt SP, Klapp BF, Arck PC and Peters EM: Further exploring the brain-skin connection: Stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol. 128:434–446. 2008. View Article : Google Scholar : PubMed/NCBI
22	Căruntu C, Negrei C, Ghiţă MA, Căruntu A, Bădărău AI, Buraga I, Boda D, Albu A and Branisteanu D: Capsaicin, a hot topic in skin pharmacology and physiology. Farmacia. 63:487–491. 2015.
23	Căruntu C and Boda D: Evaluation through in vivo reflectance confocal microscopy of the cutaneous neurogenic inflammatory reaction induced by capsaicin in human subjects. J Biomed Opt. 17:0850032012. View Article : Google Scholar : PubMed/NCBI
24	Ghiţă MA, Căruntu C, Rosca AE, Căruntu A, Moraru L, Constantin C, Neagu M and Boda D: Real-time investigation of skin blood flow changes induced by topical capsaicin. Acta Dermatovenerol Croat. 25:223–227. 2017.PubMed/NCBI
25	Cohen S, Kamarck T and Mermelstein R: A global measure of perceived stress. J Health Soc Behav. 24:385–396. 1983. View Article : Google Scholar : PubMed/NCBI
26	Lang PJ, Bradley MM and Cuthbert BN: International affective picture system (IAPS): Affective ratings of pictures and instruction manual. Technical Report A-8. University of Florida; Gainesville, FL: 2008
27	Safta I, Grigore O and Căruntu C: Emotion detection using psycho-physiological signal processing. 2011 7th International Symposium on Advanced Topics in Electrical Engineering (ATEE). May 12-14–2011.https://ieeexplore.ieee.org/document/5952203
28	Dedovic K, Renwick R, Mahani NK, Engert V, Lupien SJ and Pruessner JC: The Montreal imaging stress task: Using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain. J Psychiatry Neurosci. 30:319–325. 2005.PubMed/NCBI
29	Raven JC: Standardization of progressive matrices, 1938. Br J Med Psychol. 19:137–150. 1941. View Article : Google Scholar
30	Raven J: The Raven's progressive matrices: Change and stability over culture and time. Cognit Psychol. 41:1–48. 2000. View Article : Google Scholar : PubMed/NCBI
31	Schmidt S and Walach H: Electrodermal activity (EDA): State of the art measurement and techniques for parapsychological purposes. J Parapsychol. 64:139–163. 2000.
32	You DS, Creech SK and Meagher MW: Enhanced area of secondary hyperalgesia in women with multiple stressful life events: A pilot study. Pain Med. 17:1859–1864. 2016. View Article : Google Scholar : PubMed/NCBI
33	Lutgendorf S, Logan H, Kirchner HL, Rothrock N, Svengalis S, Iverson K and Lubaroff D: Effects of relaxation and stress on the capsaicin-induced local inflammatory response. Psychosom Med. 62:524–534. 2000. View Article : Google Scholar : PubMed/NCBI
34	Logan H, Lutgendorf S, Rainville P, Sheffield D, Iverson K and Lubaroff D: Effects of stress and relaxation on capsaicin-induced pain. J Pain. 2:160–170. 2001. View Article : Google Scholar : PubMed/NCBI
35	Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH and Lutz A: A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun. 27:174–184. 2013. View Article : Google Scholar : PubMed/NCBI
36	Rosenkranz MA, Lutz A, Perlman DM, Bachhuber DR, Schuyler BS, MacCoon DG and Davidson RJ: Reduced stress and inflammatory responsiveness in experienced meditators compared to a matched healthy control group. Psychoneuroendocrinology. 68:117–125. 2016. View Article : Google Scholar : PubMed/NCBI
37	Storm H, Myre K, Rostrup M, Stokland O, Lien MD and Raeder JC: Skin conductance correlates with perioperative stress. Acta Anaesthesiol Scand. 46:887–895. 2002. View Article : Google Scholar : PubMed/NCBI
38	Lidberg L and Wallin BG: Sympathetic skin nerve discharges in relation to amplitude of skin resistance responses. Psychophysiology. 18:268–270. 1981. View Article : Google Scholar : PubMed/NCBI
39	Lin Q, Li D, Xu X, Zou X and Fang L: Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin. Mol Pain. 3:302007. View Article : Google Scholar : PubMed/NCBI
40	Lin Q, Wu J and Willis WD: Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats. J Neurophysiol. 82:2602–2611. 1999. View Article : Google Scholar : PubMed/NCBI
41	Lin Q, Zou X, Fang L and Willis WD: Sympathetic modulation of acute cutaneous flare induced by intradermal injection of capsaicin in anesthetized rats. J Neurophysiol. 89:853–861. 2003. View Article : Google Scholar : PubMed/NCBI
42	Ren Y, Zou X, Fang L and Lin Q: Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats. J Neurophysiol. 93:365–377. 2005. View Article : Google Scholar : PubMed/NCBI
43	Bíró T, Maurer M, Modarres S, Lewin NE, Brodie C, Acs G, Acs P, Paus R and Blumberg PM: Characterization of functional vanilloid receptors expressed by mast cells. Blood. 91:1332–1340. 1998.PubMed/NCBI