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Article Open Access

MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN

  • Authors:
    • Li Zhao
    • Xue Rong Yang
    • Xu Han
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China, Department of Nursing, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China, Department of Health Care Unit, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1171-1181
    |
    Published online on: December 12, 2018
       https://doi.org/10.3892/etm.2018.7087
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Abstract

The aim of the present study was to investigate the function of microRNA‑146b on myocardial infarction and the mechanism. An MTT assay, Annexin V/propidium iodide (PI) apoptosis assay, ELISA kits, western blot analysis and a caspase‑3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory factors, and the B‑cell lymphoma 2‑associated X protein (Bax), phosphatase and tensin homolog (PTEN), phosphoinositide 3‑kinase (PI3K)/Akt/nuclear factor (NF)‑κB signaling pathway. The expression of microRNA‑146b was downregulated in the myocardial infarction rat model, compared with the control group. In an in vitro model of myocardial infarction, the downregulation of microRNA‑146b increased inflammatory factors, vascular apoptosis, caspase‑3/8 activity and the protein expression of Bax. MicroRNA‑146b reduced vascular apoptosis, caspase‑3/8 activity and the protein expression of Bax. MicroRNA‑146b also regulated the PI3K/Akt/NF‑κB signaling pathway to mediate vascular inflammation and apoptosis in myocardial infarction by PTEN. A PI3K inhibitor decreased the effect of microRNA‑146b on vascular inflammation and apoptosis following myocardial infarction. In conclusion, microRNA‑146b mediated vascular inflammation and apoptosis in patients with myocardial infarction, which may be associated with activation of the PI3K/Akt/NF‑κB signaling pathway by PTEN.
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1 

Lavi S, Alemayehu M, McCarty D, Warrington J and Lavi R: One-year outcome of the sevoflurane in acute myocardial infarction randomized trial. Can J Anaesth. 62:1279–1286. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Galea N, Francone M, Zaccagna F, Ciolina F, Cannata D, Algeri E, Agati L, Catalano C and Carbone I: Ultra low-dose of gadobenate dimeglumine for late gadolinium enhancement (LGE) imaging in acute myocardial infarction: A feasibility study. Eur J Radiol. 83:2151–2158. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Xu L, Cai Z, Xiong M, Li Y, Li G, Deng Y, Hau WK, Li S, Huang W and Qiu J: Efficacy of an early home-based cardiac rehabilitation program for patients after acute myocardial infarction: A three-dimensional speckle tracking echocardiography randomized trial. Medicine (Baltimore). 95:e56382016. View Article : Google Scholar : PubMed/NCBI

4 

Liu M, Mao C, Li J, Han F and Yang P: Effects of the Activin A-Follistatin System on myocardial cell apoptosis through the endoplasmic reticulum stress pathway in heart failure. Int J Mol Sci. 18:2017.

5 

Chen TL, Zhu GL, He XL, Wang JA, Wang Y and Qi GA: Short-term pretreatment with atorvastatin attenuates left ventricular dysfunction, reduces infarct size and apoptosis in acute myocardial infarction rats. Int J Clin Exp Med. 7:4799–4808. 2014.PubMed/NCBI

6 

Boshra V and Atwa A: Effect of cerebrolysin on oxidative stress-induced apoptosis in an experimental rat model of myocardial ischemia. Physiol Int. 103:310–320. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Cheng XY, Gu XY, Gao Q, Zong QF, Li XH and Zhang Y: Effects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injury. Mol Med Rep. 14:797–803. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Li CM, Shen SW, Wang T and Zhang XH: Myocardial ischemic post-conditioning attenuates ischemia reperfusion injury via PTEN/Akt signal pathway. Int J Clin Exp Med. 8:15801–15807. 2015.PubMed/NCBI

9 

Lu C, Wang X, Ha T, Hu Y, Liu L, Zhang X, Yu H, Miao J, Kao R, Kalbfleisch J, et al: Attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a are mediated by suppression of PTEN and activation of PI3K dependent signaling. J Mol Cell Cardiol. 89:87–97. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Li H, Song F, Duan LR, Sheng JJ, Xie YH, Yang Q, Chen Y, Dong QQ, Zhang BL and Wang SW: Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway. Sci Rep. 6:236932016. View Article : Google Scholar : PubMed/NCBI

11 

Raish M: Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-kappaB signaling pathway. Int J Biol Macromol. 97:544–551. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Liu Y, Xing R, Zhang X, Dong W, Zhang J, Yan Z, Li W, Cui J and Lu Y: miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair (Amst). 12:741–750. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Zhuo SM, Li SC, Lin YQ, Yu HB and Li N: The effects of anti-Fas ribozyme on T lymphocyte apoptosis in mice model with chronic obstructive pulmonary disease. Iran J Basic Med Sci. 20:1102–1108. 2017.PubMed/NCBI

14 

Zhang MJ, Su H, Yan JY, Li N, Song ZY, Wang HJ, Huo LG, Wang F, Ji WS, Qu XJ and Qu MH: Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice. Biomed Pharmacother. 97:1131–1137. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Ramirez-Moya J, Wert-Lamas L and Santisteban P: MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN. Oncogene. 37:3369–3383. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Hendgen-Cotta UB, Messiha D, Esfeld S, Deenen R, Rassaf T and Totzeck M: Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion. Free Radic Res. 51:91–102. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Boghdady A and Elbadry MI: Comparison of successful myocardial reperfusion and adverse events in patients with ST-Elevation myocardial infarction who underwent rescue percutaneous coronary intervention after failed fibrinolytic therapy with vs. without manual coronary thrombus aspiration. Am J Cardiol. 116:1185–1192. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Tanaka S, Masuda T, Kamiya K, Hamazaki N, Akiyama A, Kamada Y, Maekawa E, Noda C, Yamaoka-Tojo M and Ako J: A single session of neuromuscular electrical stimulation enhances vascular endothelial function and peripheral blood circulation in patients with acute myocardial infarction. Int Heart J. 57:676–681. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Song XJ, Yang CY, Liu B, Wei Q, Korkor MT, Liu JY and Yang P: Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 8:564–572. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Poss J, Desch S, Eitel C, de Waha S, Thiele H and Eitel I: Left ventricular thrombus formation after ST-segment-elevation myocardial infarction: Insights from a cardiac magnetic resonance multicenter study. Circ Cardiovasc Imaging. 8:e0034172015. View Article : Google Scholar : PubMed/NCBI

22 

Roubille F, Combes S, Leal-Sanchez J, Barrère C, Cransac F, Sportouch-Dukhan C, Gahide G, Serre I, Kupfer E, Richard S, et al: Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury. Circulation. 116:2709–2717. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lin N and An Y: Blockade of 146b-5p promotes inflammation in atherosclerosis-associated foam cell formation by targeting TRAF6. Exp Ther Med. 14:5087–5092. 2017.PubMed/NCBI

24 

Sun Y, Huang J and Song K: BET protein inhibition mitigates acute myocardial infarction damage in rats via the TLR4/TRAF6/NF-kappaB pathway. Exp Ther Med. 10:2319–2324. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Jin JL, Lv RG, Guo J, Liu XH, Liang YW, Wei JR and Wang L: Improvement of left ventricular remodelling by inhibition of NF-kappaB in a rat model of myocardial infarction. Heart Lung Circ. 25:1007–1012. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Jiang W, Liu J, Dai Y, Zhou N, Ji C and Li X: MiR-146b attenuates high-fat diet-induced non-alcoholic steatohepatitis in mice. J Gastroenterol Hepatol. 30:933–943. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Lee TM, Chang NC and Lin SZ: Inhibition of infarction-induced sympathetic innervation with endothelin receptor antagonism via a PI3K/GSK-3beta-dependent pathway. Lab Invest. 97:243–255. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Liu S, Ai Q, Feng K, Li Y and Liu X: The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1alpha signaling pathways. Apoptosis. 21:1366–1385. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Yang XR and Han X: MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Exp Ther Med 17: 1171-1181, 2019.
APA
Zhao, L., Yang, X.R., & Han, X. (2019). MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and Therapeutic Medicine, 17, 1171-1181. https://doi.org/10.3892/etm.2018.7087
MLA
Zhao, L., Yang, X. R., Han, X."MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN". Experimental and Therapeutic Medicine 17.2 (2019): 1171-1181.
Chicago
Zhao, L., Yang, X. R., Han, X."MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1171-1181. https://doi.org/10.3892/etm.2018.7087
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Yang XR and Han X: MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Exp Ther Med 17: 1171-1181, 2019.
APA
Zhao, L., Yang, X.R., & Han, X. (2019). MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and Therapeutic Medicine, 17, 1171-1181. https://doi.org/10.3892/etm.2018.7087
MLA
Zhao, L., Yang, X. R., Han, X."MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN". Experimental and Therapeutic Medicine 17.2 (2019): 1171-1181.
Chicago
Zhao, L., Yang, X. R., Han, X."MicroRNA‑146b induces the PI3K/Akt/NF‑κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1171-1181. https://doi.org/10.3892/etm.2018.7087
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