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Article

Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy

  • Authors:
    • Wen‑Wen Han
    • Li‑Jun Tang
    • Xiang‑Lei Kong
    • Huan Yang
    • Dong‑Mei Xu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Nephrology, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 1825-1830
    |
    Published online on: December 18, 2018
       https://doi.org/10.3892/etm.2018.7108
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Abstract

The present study aimed to explore the correlation between the dynamic serum levels of phospholipase A2 receptor (PLA2R), aldose reductase (AR) and superoxide dismutase 2(SOD2) antibodies with disease activity and treatment response in patients with idiopathic membranous nephropathy (IMN). The present study included 56 patients with IMN who were diagnosed through a renal biopsy and presenting with nephrotic syndrome. The patients were divided into two treatment groups: One treated with cyclophosphamide (CTX) and one with tacrolimus (FK506). Serum was collected prior to treatment, and at 1, 3, 6, 9 and 12 months after the start of the 12‑month‑long therapy. Samples were tested by ELISA to measure anti‑PLA2R, anti‑AR and anti‑SOD2 antibody titers. In addition, urinary protein excretion, serum albumin (Alb) and other blood biochemical indexes were measured. Theanti‑PLA2R antibody positivity rate was 71.43% in the patients prior to treatment. After 12 months of treatment, proteinuria and PLA2R antibody levels were decreased, whereas serum Alb was increased. There was no significant difference of remission rates between the CTX and FK506 groups. In conclusion, the results of the present study indicate that the anti‑PLA2R antibody level is correlated with the severity of IMN, whereas anti‑AR and anti‑SOD2 antibody levels are not. In addition, there was no significant difference between the CTX and FK506 groups in regards to the remission rates of patients with IMN.
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Copy and paste a formatted citation
Spandidos Publications style
Han WW, Tang LJ, Kong XL, Yang H and Xu DM: Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy. Exp Ther Med 17: 1825-1830, 2019.
APA
Han, W., Tang, L., Kong, X., Yang, H., & Xu, D. (2019). Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy. Experimental and Therapeutic Medicine, 17, 1825-1830. https://doi.org/10.3892/etm.2018.7108
MLA
Han, W., Tang, L., Kong, X., Yang, H., Xu, D."Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy". Experimental and Therapeutic Medicine 17.3 (2019): 1825-1830.
Chicago
Han, W., Tang, L., Kong, X., Yang, H., Xu, D."Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1825-1830. https://doi.org/10.3892/etm.2018.7108
Copy and paste a formatted citation
x
Spandidos Publications style
Han WW, Tang LJ, Kong XL, Yang H and Xu DM: Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy. Exp Ther Med 17: 1825-1830, 2019.
APA
Han, W., Tang, L., Kong, X., Yang, H., & Xu, D. (2019). Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy. Experimental and Therapeutic Medicine, 17, 1825-1830. https://doi.org/10.3892/etm.2018.7108
MLA
Han, W., Tang, L., Kong, X., Yang, H., Xu, D."Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy". Experimental and Therapeutic Medicine 17.3 (2019): 1825-1830.
Chicago
Han, W., Tang, L., Kong, X., Yang, H., Xu, D."Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1825-1830. https://doi.org/10.3892/etm.2018.7108
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