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The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling

  • Authors:
    • Jiedong Liang
    • Gui Deng
    • He Huang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, China Three Gorges University, Yichang, Hubei 443000, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1688-1696
    |
    Published online on: December 18, 2018
       https://doi.org/10.3892/etm.2018.7109
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Abstract

The aim of the present study was to investigate the pro‑inflammation effects of brain‑derived neurotrophic factor (BDNF) signaling in promoting inflammation following spinal cord injury (SCI) in rats. Reverse transcription‑quantitative polymerase chain reaction was used to detect the expression of BDNF in SCI rats. The Basso, Beattie and Bresnahan (BBB) test was used and the water content of spinal cord were assessed to determine the effects of BDNF on SCI. BDNF expression was increased in SCI rats. In an in vitro model, overexpression of BDNF induced the protein expression of tyrosine kinase receptor B (TrkB) and suppressed that of phosphorylated (p‑)p38, and reduced inflammation, as indicated by tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL‑6, IL‑18, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)‑2 levels. Conversely, the TrkB inhibitor ANA‑12 suppressed the protein expression of TrkB and induced that of p‑p38, and promoted inflammation (as indicated by TNF‑α, IL‑1β, IL‑6, IL‑18, iNOS and COX‑2 levels) in an in vitro model of SCI by BDNF overexpression. In addition, the p38 inhibitor TA‑0, suppressed p38 protein expression and reduced inflammation in an in vitro model of SCI by BDNF overexpression. Together, these data suggest that the pro‑inflammation effects of BDNF/TrkB promoted inflammation in SCI through p38 signaling in rats.
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1 

de Araujo AVL, Barbosa VRN, Galdino GS, Fregni F, Massetti T, Fontes SL, de Oliveira Silva D, da Silva TD, Monteiro CBM, Tonks J and Magalhães FH: Effects of high-frequency transcranial magnetic stimulation on functional performance in individuals with incomplete spinal cord injury: Study protocol for a randomized controlled trial. Trials. 18:5222017. View Article : Google Scholar : PubMed/NCBI

2 

Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T and Saito S: Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia. Autophagy. 9:303–316. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W and Su H: VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun. 376:419–422. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Tsuzuki T, Okada H, Cho H, Tsuji S, Nishigaki A, Yasuda K and Kanzaki H: Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1α and inhibits stromal cell-derived factor-1 in human endometrial stromal cells. Hum Reprod. 27:523–530. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Ottosen LD, Hindkaer J, Husth M, Petersen DE, Kirk J and Ingerslev HJ: Observations on intrauterine oxygen tension measured by fibre-optic microsensors. Reprod Biomed Online. 13:380–385. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kuhn NZ and Tuan RS: Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis. J Cell Physiol. 222:268–277. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Kato K: Stem cells in human normal endometrium and endometrial cancer cells: Characterization of side population cells. Kaohsiung J Med Sci. 28:63–71. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Schwab KE, Hutchinson P and Gargett CE: Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells. Hum Reprod. 23:934–943. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Miernik K and Karasinski J: Porcine uterus contains a population of mesenchymal stem cells. Reproduction. 143:203–209. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang L, Xiong W, Xiong Y, Liu H, Li N, Du Y and Liu Y: Intracellular Wnt/beta-catenin signaling underlying 17beta-estradiol-induced matrix metalloproteinase 9 expression in human endometriosis. Biol Reprod. 94:702016. View Article : Google Scholar : PubMed/NCBI

11 

Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B and Taylor HS: Serum microRNAs as diagnostic markers of endometriosis: A comprehensive array-based analysis. Fertil Steril. 106:402–409. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Panda H, Pelakh L, Chuang TD, Luo X, Bukulmez O and Chegini N: Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKKβ, KLF9, and FBLN5. Reprod Sci. 19:786–796. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Furuya M, Masuda H, Hara K, Uchida H, Sato K, Sato S, Asada H, Maruyama T, Yoshimura Y, Katabuchi H, et al: ZEB1 expression is a potential indicator of invasive endometriosis. Acta Obstet Gynecol Scand. 96:1128–1135. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Sanchez AM, Vigano P, Quattrone F, Pagliardini L, Papaleo E, Candiani M and Panina-Bordignon P: The WNT/β-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: Endometriosis as a paradigm for a dysregulated apoptosis pathway. Fertil Steril. 101:1688–1696. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Kim SH, Park JG, Lee J, Yang WS, Park GW, Kim HG, Yi YS, Baek KS, Sung NY, Hossen MJ, et al: The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets. Mediators Inflamm. 2015:9041422015. View Article : Google Scholar : PubMed/NCBI

16 

Zhang JC, Yao W and Hashimoto K: Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets. Curr Neuropharmacol. 14:721–731. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA, Holford TR, Hsu CY, Noble LJ, Nockels R, et al: MASCIS evaluation of open field locomotor scores: Effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 13:343–359. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Cindolo L, Chiodini P, Brookman-May S, De Cobelli O, May M, Squillacciotti S, De Nunzio C, Tubaro A, Coman I, Feciche B, et al: Assessing the accuracy and generalizability of the preoperative and postoperative karakiewicz nomograms for renal cell carcinoma: Results from a multicentre European and US study. BJU Int. 112:578–584. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Masuda H, Maruyama T, Gargett CE, Miyazaki K, Matsuzaki Y, Okano H and Tanaka M: Endometrial side population cells: Potential adult stem/progenitor cells in endometrium. Biol Reprod. 93:842015. View Article : Google Scholar : PubMed/NCBI

21 

Siebels M, Rohrmann K, Oberneder R, Stahler M, Haseke N, Beck J, Hofmann R, Kindler M, Kloepfer P and Stief C: A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(R)) and interferon-alpha-2a in metastatic renal cell carcinoma patients. World J Urol. 29:121–126. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Opper B, Elsner P and Ziemer M: Cutaneous metastasis of renal cell carcinoma. Am J Clin Dermatol. 7:271–272. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Liang W, Guan H, He X, Ke W, Xu L, Liu L, Xiao H and Li Y: Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. Oncotarget. 6:31780–31791. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Jhaveri KS, Elmi A, Hosseini-Nik H, Hedgire S, Evans A, Jewett M and Harisinghani M: Predictive value of chemical-shift MRI in distinguishing clear cell renal cell carcinoma from non-clear cell renal cell carcinoma and minimal-fat angiomyolipoma. AJR Am J Roentgenol. 205:W79–W86. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Rini BI, Plimack ER, Takagi T, Elson P, Wood LS, Dreicer R, Gilligan T, Garcia J, Zhang Z, Kaouk J, et al: A Phase II study of pazopanib in patients with localized renal cell carcinoma to optimize preservation of renal parenchyma. J Urol. 194:297–303. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Guo R, Overman M, Chatterjee D, Rashid A, Shroff S and Wang H, Katz MH, Fleming JB, Varadhachary GR, Abbruzzese JL and Wang H: Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma. Hum Pathol. 45:1015–1023. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Erdem H, Oktay M, Yildirim U, Uzunlar AK and Kayikci MA: Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: A microarray study. Pol J Pathol. 64:28–32. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Mishra SK and Crasta JA: An immunohistochemical comparison of P53 and Bcl-2 as apoptotic and MIB1 as proliferative markers in low-grade and high-grade ovarian serous carcinomas. Int J Gynecol Cancer. 20:537–541. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Liu G, Wang T, Wang T, Song J and Zhou Z: Effects of apoptosis-related proteins caspase-3, Bax and Bcl-2 on cerebral ischemia rats. Biomed Rep. 1:861–867. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Chang HA, Wang YH, Tung CS, Yeh CB and Liu YP: 7,8-Dihydroxyflavone, a tropomyosin-kinase related receptor B agonist, produces fast-onset antidepressant-like effects in rats exposed to chronic mild stress. Psychiatry Investig. 13:531–540. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Guo YB, Bao XJ, Xu SB, Zhang XD and Liu HY: Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells. Int J Clin Exp Med. 8:7168–7175. 2015.PubMed/NCBI

32 

De Giorgi U, Yuan J, Moroni M, Veronese S, Sartore-Bianchi A, Broggini M, Rosti G, Strebhardt K and Ruffini PA: Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function. Int J Biol Markers. 30:e275–e281. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Han M, Zhang JC, Yao W, Yang C, Ishima T, Ren Q, Ma M, Dong C, Huang XF and Hashimoto K: Intake of 7,8-dihydroxyflavone during juvenile and adolescent stages prevents onset of psychosis in adult offspring after maternal immune activation. Sci Rep. 6:360872016. View Article : Google Scholar : PubMed/NCBI

34 

Zhuang Z, Ye G and Huang B: Kaempferol alleviates the interleukin-1β-induced inflammation in rat osteoarthritis chondrocytes via suppression of NF-kB. Med Sci Monit. 23:3925–3931. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Park HY, Park C, Hwang HJ, Kim BW, Kim GY, Kim CM, Kim ND and Choi YH: 7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-κB and MAPK signaling pathways. Int J Mol Med. 33:1027–1034. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang J, Deng G and Huang H: The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Exp Ther Med 17: 1688-1696, 2019.
APA
Liang, J., Deng, G., & Huang, H. (2019). The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Experimental and Therapeutic Medicine, 17, 1688-1696. https://doi.org/10.3892/etm.2018.7109
MLA
Liang, J., Deng, G., Huang, H."The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling". Experimental and Therapeutic Medicine 17.3 (2019): 1688-1696.
Chicago
Liang, J., Deng, G., Huang, H."The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1688-1696. https://doi.org/10.3892/etm.2018.7109
Copy and paste a formatted citation
x
Spandidos Publications style
Liang J, Deng G and Huang H: The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Exp Ther Med 17: 1688-1696, 2019.
APA
Liang, J., Deng, G., & Huang, H. (2019). The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Experimental and Therapeutic Medicine, 17, 1688-1696. https://doi.org/10.3892/etm.2018.7109
MLA
Liang, J., Deng, G., Huang, H."The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling". Experimental and Therapeutic Medicine 17.3 (2019): 1688-1696.
Chicago
Liang, J., Deng, G., Huang, H."The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1688-1696. https://doi.org/10.3892/etm.2018.7109
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