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Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD

  • Authors:
    • Weijing Liu
    • Tao Wang
    • Pengfei Sun
    • Yanju Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1756-1760
    |
    Published online on: December 18, 2018
       https://doi.org/10.3892/etm.2018.7111
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Abstract

Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high‑density lipoprotein cholesterol (HDL‑C) and low‑density lipoprotein cholesterol (LDL‑C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL‑C in patients in the study group were significantly higher than that in control group, while the HDL‑C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL‑C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL‑C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL‑C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Wang T, Sun P and Zhou Y: Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD. Exp Ther Med 17: 1756-1760, 2019.
APA
Liu, W., Wang, T., Sun, P., & Zhou, Y. (2019). Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD. Experimental and Therapeutic Medicine, 17, 1756-1760. https://doi.org/10.3892/etm.2018.7111
MLA
Liu, W., Wang, T., Sun, P., Zhou, Y."Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD". Experimental and Therapeutic Medicine 17.3 (2019): 1756-1760.
Chicago
Liu, W., Wang, T., Sun, P., Zhou, Y."Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1756-1760. https://doi.org/10.3892/etm.2018.7111
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Wang T, Sun P and Zhou Y: Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD. Exp Ther Med 17: 1756-1760, 2019.
APA
Liu, W., Wang, T., Sun, P., & Zhou, Y. (2019). Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD. Experimental and Therapeutic Medicine, 17, 1756-1760. https://doi.org/10.3892/etm.2018.7111
MLA
Liu, W., Wang, T., Sun, P., Zhou, Y."Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD". Experimental and Therapeutic Medicine 17.3 (2019): 1756-1760.
Chicago
Liu, W., Wang, T., Sun, P., Zhou, Y."Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1756-1760. https://doi.org/10.3892/etm.2018.7111
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