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MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN

  • Authors:
    • Peng Wu
    • Lingchen Kong
    • Jianzhong Li
  • View Affiliations / Copyright

    Affiliations: Intensive Medicine Department, Linyi Central Hospital, Linyi, Shandong 276400, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1706-1716
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    Published online on: December 19, 2018
       https://doi.org/10.3892/etm.2018.7116
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Abstract

The aim of the present study was to investigate the role of microRNA (miR)‑494‑3p in myocardial injury in patients with septic shock and the underlying mechanism. A total of 22 patients with sepsis and 17 patients with septic shock were included in the present study. In addition, 20 healthy subjects were recruited as the control group. Peripheral blood was collected from all subjects and a rat cardiomyocyte model of myocardial injury was constructed. Reverse transcription‑quantitative polymerase chain reaction was used to measure miR‑494‑3p expression, while cell counting kit‑8 assays were performed to assess cell proliferation. Flow cytometry was performed to investigate cell cycle distribution and apoptosis. Lactate dehydrogenase (LDH) assays were performed to measure LDH levels. ELISA was also performed to measure LDH, tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 levels in cell culture supernatants. Western blotting was employed to detect phosphatase and tensin homolog (PTEN) protein expression and dual luciferase reporter assays were performed to identify the interaction between miR‑494‑3p and PTEN mRNA. Reduced miR‑494‑3p expression was correlated with myocardial damage in patients with septic shock. Sera from patients with septic shock downregulated miR‑494‑3p expression in rat cardiomyocytes. miR‑494‑3p overexpression inhibited rat cardiomyocyte injury induced by treatment with sera from patients with septic shock. Furthermore, miR‑494‑3p overexpression reduced the synthesis and release of TNF‑α and IL‑6 from rat cardiomyocytes. PTEN knockdown alleviated rat cardiomyocyte injury following treatment with serum from patients with septic shock. PTEN was demonstrated to induce the release of TNF‑α and IL‑6 from rat cardiomyocytes treated with septic shock serum, while miR‑494‑3p was demonstrated to bind to the 3'‑untranslated seed region of PTEN mRNA to regulate its expression. The results of the present study suggest that miR‑494‑3p is downregulated in the peripheral blood of patients with septic shock and is negatively correlated with myocardial injury. The present study also indicates that miR‑494‑3p regulates PTEN expression, inhibits sepsis‑induced myocardial injury and protects the function of cardiomyocytes. The protective effect and mechanism of action of miR‑494‑3p indicate that it has potential for use in the clinical diagnosis and therapy of myocardial damage.
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View References

1 

Liu Y, Wan W, Fang F, Guo L, Zhao Y, Zhang X and Huang F: Clinical relevance of peroxisome proliferator-activated receptor-gamma gene polymorphisms with sepsis. J Clin Lab Anal. 32:e223402018. View Article : Google Scholar : PubMed/NCBI

2 

Zhou X, Ding B, Ye Y, Tang G and Zhang Z: An appropriate mean arterial pressure (MAP) does not always mean hemodynamic stability in septic shock patients. J Crit Care. 43:397–398. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Santos-Junior MN, Rezende IS, Souza CLS, Barbosa MS, Campos GB, Brito LF, Queiroz ÉC, Barbosa EN, Teixeira MM, Da Silva LO, et al: Ureaplasma diversum and its membrane-associated lipoproteins activate inflammatory genes through the NF-κB pathway via toll-like receptor 4. Front Microbiol. 9:15382018. View Article : Google Scholar : PubMed/NCBI

4 

Zasada M, Lenart M, Rutkowska-Zapala M, Stec M, Durlak W, Grudzień A, Krzeczkowska A, Mól N, Pilch M, Siedlar M and Kwinta P: Analysis of PD-1 expression in the monocyte subsets from non-septic and septic preterm neonates. PLoS One. 12:e01868192017. View Article : Google Scholar : PubMed/NCBI

5 

Xu LY and Xu D: Changes in blood oxygen metabolism indices and their clinical significance in children with septic shock. Zhongguo Dang Dai Er Ke Za Zhi. 19:1124–1128. 2017.(In Chinese). PubMed/NCBI

6 

Dargent A, Nguyen M, Fournel I, Bourredjem A, Charles PE and Quenot JP; EPISS study group, : Vasopressor cumulative dose requirement and risk of early death during septic shock: An analysis from the episs cohort. Shock. 49:625–630. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Sharawy N, Mahrous R, Whynot S, George R and Lehmann C: Clinical relevance of early sublingual microcirculation monitoring in septic shock patients. Clin Hemorheol Microcirc. 68:347–359. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Park JS, Choi HS, Yim SY and Lee SM: Heme oxygenase-1 protects the liver from septic injury by modulating tLR4-mediated mitochondrial quality control in mice. Shock. 50:209–218. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Ding W and Jiang L: The Effects of afebrile characteristic on patients with suspected septic shock: Several facts need to be noticed. Crit Care Med. 45:e11912017. View Article : Google Scholar : PubMed/NCBI

10 

Kim YC, Song JE, Kim EJ, Choi H, Jeong WY, Jung IY, Jeong SJ, Ku NS, Choi JY, Song YG and Kim JM: A simple scoring system using the red blood cell distribution width, delta neutrophil index, and platelet count to predict mortality in patients with severe sepsis and septic shock. J Intensive Care Med. 1:8850666187874482018.

11 

Vazquez-Guillamet MC, Vazquez R, Micek ST and Kollef MH: Predicting resistance to piperacillin-tazobactam, cefepime and meropenem in septic patients with bloodstream infection due to gram-negative bacteria. Clin Infect Dis. 65:1607–1614. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Erwin BL, Denaburg MA, Barker AB, McArdle PJ, Windham ST and Morgan CJ: Evaluation of vasopressin for septic shock in patients on chronic renin-angiotensin-aldosterone system inhibitors. Crit Care Med. 45:e1226–e1232. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Hyvernat H, Doyen D, Barel R, Kaidomar M, Goubaux B, Pradier C, Panaïa-Ferrari P, Dellamonica J and Bernardin G: Is inappropriate response to cosyntropin stimulation test an indication of corticosteroid resistance in septic shock? Shock. 498:543–550. 2018. View Article : Google Scholar

14 

Makara MA, Hoang KV, Ganesan LP, Crouser ED, Gunn JS, Turner J, Schlesinger LS, Mohler PJ and Rajaram MV: Cardiac electrical and structural changes during bacterial infection: An instructive model to study cardiac dysfunction in sepsis. J Am Heart Assoc. 5:e0038202016. View Article : Google Scholar : PubMed/NCBI

15 

Martin L, Peters C, Schmitz S, Moellmann J, Martincuks A, Heussen N, Lehrke M, Müller-Newen G, Marx G and Schuerholz T: Soluble heparan sulfate in serum of septic shock patients induces mitochondrial dysfunction in murine cardiomyocytes. Shock. 44:569–577. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Huang L, Zheng M, Zhou Y, Zhu J, Zhu M, Zhao F and Cui S: Tanshinone IIA attenuates cardiac dysfunction in endotoxin-induced septic mice via inhibition of NADPH oxidase 2-related signaling pathway. Int Immunopharmacol. 28:444–449. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Feng Y, Zou L, Chen C, Li D and Chao W: Role of cardiac- and myeloid-MyD88 signaling in endotoxin shock: A study with tissue-specific deletion models. Anesthesiology. 121:1258–1269. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, Fujii-Kuriyama Y, Sakamato S, Ito T, Handa H, Tanaka T, et al: NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. J Exp Med. 215:2197–2209. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Gu X, Wei C, Zhu X, Lu F, Sheng B and Zang X: Effect of interleukin-31 on septic shock through regulating inflammasomes and interleukin-1β. Exp Ther Med. 16:171–177. 2018.PubMed/NCBI

20 

Li T, Sun XZ, Lai DH, Li X and He YZ: Fever and systemic inflammatory response syndrome after retrograde intrarenal surgery: Risk factors and predictive model. Kaohsiung J Med Sci1. 34:400–408. 2018. View Article : Google Scholar

21 

Kawamoto E, Masui-Ito A, Eguchi A, Soe ZY, Prajuabjinda O, Darkwah S, Park EJ, Imai H and Shimaoka M: Integrin and PD-1 ligand expression on circulating extracellular vesicles in systemic inflammatory response syndrome and sepsis. Shock. 2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

22 

Zhao W, Shen G, Ren H, Liang, Yu X, Zhang Z, Huang J, Qiu T, Tang J, Shang Q, et al: Therapeutic potential of microRNAs in osteoporosis function by regulating the biology of cells related to bone homeostasis. J Cell Physiol. 2018.(Epub ahead of print).

23 

Kanthaje S, Makol A and Chakraborti A: Sorafenib response in hepatocellular carcinoma: MicroRNAs as tuning forks miRNAs as regulators of sorafenib response in HCC. Hepatol Res. 38:5–14. 2018. View Article : Google Scholar

24 

Thyagarajan A, Shaban A and Sahu RP: miRNA directed cancer therapies: Implications in melanoma intervention. J Pharmacol Exp Ther. 364:1–12. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Ge C, Liu J and Dong S: MIRNA-214 protects sepsis-induced myocardial injury. Shock. 50:112–118. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Diao H, Liu B, Shi Y, Song C, Guo Z, Liu N, Song X, Lu Y, Lin X and Li Z: MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. Biosci Biotechnol Biochem. 81:1712–1720. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, Rossi C, Ruberti S, Bianchi E, Barbieri G, et al: Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget. 8:49451–49469. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER and Quax PH: Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia. Circ Res. 115:696–708. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Yao R, Feng WT, Xu LJ, Zhong XM, Liu H, Sun Y and Zhou LL: DUXAP10 regulates proliferation and apoptosis of chronic myeloid leukemia via PTEN pathway. Eur Rev Med Pharmacol Sci. 22:4934–4940. 2018.PubMed/NCBI

30 

Sun G, Lu Y, Li Y, Mao J, Zhang J, Jin Y, Li Y, Sun Y, Liu L and Li L: miR-19a protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis via PTEN/PI3K/p-Akt pathway. Biosci Rep. 37:2017. View Article : Google Scholar

31 

Liu L, Yan X, Wu D, Yang Y, Li M, Su Y, Yang W, Shan Z, Gao Y and Jin Z: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway. J Exp Clin Cancer Res. 37:1782018. View Article : Google Scholar : PubMed/NCBI

32 

Zhang J, Li L, Peng Y, Chen Y, Lv X, Li S, Qin X, Yang H, Wu C and Liu Y: Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway. Biochim Biophys Acta. 1865:172–185. 2018. View Article : Google Scholar

33 

Pero-Gascon R, Sanz-Nebot V, Berezovski MV and Benavente F: Analysis of circulating microRNAs and their post-transcriptional modifications in cancer serum by on-line solid-phase extraction-capillary electrophoresis-mass spectrometry. Anal Chem. 90:6618–6625. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Gossack-Keenan KL and Kam AJ: Toxic shock syndrome: Still a timely diagnosis. Pediatr Emerg Car. 2017.(Epub ahead of print). View Article : Google Scholar

36 

Zhang M, Zou L, Feng Y, Chen YJ, Zhou Q, Ichinose F and Chao W: Toll-like receptor 4 is essential to preserving cardiac function and survival in low-grade polymicrobial sepsis. Anesthesiology. 121:1270–1280. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Krome S: MikroRNA im septischen Schock verändert. Anästhesiol Intensivmed Notfallmed Schmerzther. 51:654. 2016. View Article : Google Scholar

38 

Geng L, Zhang T, Liu W and Chen Y: miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3. Neurosci Lett. 675:23–30. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Wang Y, Ouyang M, Wang Q and Jian Z: MicroRNA-142-3p inhibits hypoxia/reoxygenationinduced apoptosis and fibrosis of cardiomyocytes by targeting high mobility group box 1. Int J Mol Med. 38:1377–1386. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Li Y, Wen S, Yao X, Liu W, Shen J, Deng W, Tang J, Li C and Liu K: MicroRNA-378 protects against intestinal ischemia/reperfusion injury via a mechanism involving the inhibition of intestinal mucosal cell apoptosis. Cell Death Dis. 8:e31272017. View Article : Google Scholar : PubMed/NCBI

41 

Zheng HZ, Fu XK, Shang JL, Lu RX, Ou YF and Chen CL: Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1. Eur J Pharmacol. 822:154–167. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Su S, Luo, Liu X, Liu J, Peng F, Fang C and Li B: miR-494 up-regulates the PI3K/Akt pathway via targetting PTEN and attenuates hepatic ischemia/reperfusion injury in a rat model. Biosci Rep. 37:2017. View Article : Google Scholar

43 

Zhu H, Xie R, Liu X, Shou J, Gu W, Gu S and Che X: MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. Biomed Pharmacother. 92:879–887. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu P, Kong L and Li J: MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN. Exp Ther Med 17: 1706-1716, 2019.
APA
Wu, P., Kong, L., & Li, J. (2019). MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN. Experimental and Therapeutic Medicine, 17, 1706-1716. https://doi.org/10.3892/etm.2018.7116
MLA
Wu, P., Kong, L., Li, J."MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN". Experimental and Therapeutic Medicine 17.3 (2019): 1706-1716.
Chicago
Wu, P., Kong, L., Li, J."MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1706-1716. https://doi.org/10.3892/etm.2018.7116
Copy and paste a formatted citation
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Spandidos Publications style
Wu P, Kong L and Li J: MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN. Exp Ther Med 17: 1706-1716, 2019.
APA
Wu, P., Kong, L., & Li, J. (2019). MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN. Experimental and Therapeutic Medicine, 17, 1706-1716. https://doi.org/10.3892/etm.2018.7116
MLA
Wu, P., Kong, L., Li, J."MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN". Experimental and Therapeutic Medicine 17.3 (2019): 1706-1716.
Chicago
Wu, P., Kong, L., Li, J."MicroRNA‑494‑3p protects rat cardiomyocytes against septic shock via PTEN". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1706-1716. https://doi.org/10.3892/etm.2018.7116
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