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Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis

  • Authors:
    • Yan‑Hong Meng
    • Pan‑Pan Wang
    • Ya‑Xue Song
    • Jian‑Hua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Graduate School, Hebei Medical University, Shijiazhuang, Hebei 05001, P.R. China, Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1611-1624
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    Published online on: December 24, 2018
       https://doi.org/10.3892/etm.2018.7129
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Abstract

Recently, several randomized controlled trials on the use of cholinesterase inhibitors or memantine as treatments for cognitive impairment in Parkinson's disease (CIND‑PD), Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) were completed. The present study provided a meta‑analysis of these studies to evaluate the efficacy of cholinesterase inhibitors and memantine on CIND‑PD, PDD and DLB. The Cochrane Library, Pubmed, Embase and Web of Science databases were searched to retrieve eligible studies. As primary efficacy outcomes, cognitive function, global impression, behavioral symptoms and motor function were selected, while falling and adverse events were regarded as safety outcomes. Of note, domain‑specific cognitive function was assessed as a primary efficacy outcome and falling as a safety outcome, which, to the best of our knowledge, has not been studied previously in CIND‑PD, PDD and DLB. A total of 15 trials were included in the present meta‑analysis. The results revealed that treatment with cholinesterase inhibitors resulted in improvements in cognitive function, the clinician's global impression, behavioral symptoms and motor function, in accordance with the results of previous studies. Furthermore, it was revealed that cholinesterase inhibitors had a significant effect on attention, processing speed, executive functions, memory and language; however, they did not improve visuospatial cognition compared with placebos. Memantine had a significant effect on attention, processing speed and executive functions. In addition, cholinesterase inhibitors and memantine did not significantly reduce falling. It was demonstrated that an increased number of adverse events occurred in the pooled cholinesterase inhibitors and memantine group, compared with that in the placebo group (risk ratio (RR)=1.09; 95% confidence interval (CI): 1.04‑1.16; P=0.001); however, in the subgroup analysis, only the rivastigmine group experienced significantly more adverse events than the placebo group (85 vs. 73%; RR=1.18; 95% CI: 1.08‑1.29; P=0.0001), but donepezil and memantine did not produce any significant adverse events. In conclusion, cholinesterase inhibitors and memantine have an effect not only on global cognitive function and motor function, but also on attention, processing speed, executive functions, memory and language. However, careful monitoring of the side effects of rivastigmine may be required. Further clinical trials are required to verify these conclusions.
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1 

Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H and Kragh-Sørensen P: Risk of dementia in Parkinson's disease-A community-based, prospective study. Neurology. 56:730–736. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Aarsland D, Zaccai J and Brayne C: A systematic review of prevalence studies of dementia in Parkinson's disease. Mov Disord. 20:1255–1263. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Mueller C, Ballard C, Corbett A and Aarsland D: The prognosis of dementia with Lewy bodies. Lancet Neurol. 16:390–398. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, et al: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68:812–819. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Gomperts SN: Lewy body dementias: Dementia with Lewy bodies and Parkinson disease dementia. Continuum (Minneapolis Minn). 22:435–463. 2016.

6 

Matsunaga S, Kishi T and Iwata N: Memantine for Lewy body disorders: Systematic review and meta-analysis. Am J Geriatr Psychiatry. 23:373–383. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Matsunaga S, Kishi T, Yasue I and Iwata N: Cholinesterase inhibitors for Lewy body disorders: A meta-analysis. Int J Neuropsychopharmacol. 19:pyv0862015. View Article : Google Scholar : PubMed/NCBI

8 

Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, Cambridge V, Mason J, Thomas A and O'Brien JT: Pharmacological management of Lewy body dementia: A systematic review and meta-analysis. Am J Psychiatry. 172:731–742. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wang HF, Yu JT, Tang SW, Jiang T, Tan CC, Meng XF, Wang C, Tan MS and Tan L: Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies: Systematic review with meta-analysis and trial sequential analysis. J Neurol Neurosurg Psychiatry. 86:135–143. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Li Z, Yu Z and Zhang J, Wang J, Sun C, Wang P and Zhang J: Impact of rivastigmine on cognitive dysfunction and falling in Parkinson's disease patients. Eur Neurol. 74:86–91. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Gibb WR and Lees AJ: The relevance of the lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 51:745–752. 1988. View Article : Google Scholar : PubMed/NCBI

12 

Hughes AJ, Daniel SE, Kilford L and Lees AJ: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 55:181–184. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Larsen JP, Dupont E and Tandberg E: Clinical diagnosis of Parkinson's disease. Proposal of diagnostic subgroups classified at different levels of confidence. Acta Neurol Scand. 89:242–251. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I, Quinn N, Sethi KD, Shults C and Wenning GK; Movement Disorders Society Scientific Issues Committee, : Movement disorders society scientific issues committee report: SIC task force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord. 18:467–486. 2003. View Article : Google Scholar : PubMed/NCBI

15 

American Psychiatric Association (APA): Diagnostic and statistical manual of mental disorders. 4th. American Psychiatric Association; Washington, DC: 1994

16 

McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, et al: Diagnosis and management of dementia with lewy bodies: Third report of the DLB consortium. Neurology. 65:1863–1872. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Higgins JPT, Deeks JJ and Altman DG: Chapter 16: Special topics in statistics. Higgins JPT and Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration. 2011, http://www.cochrane-handbook.org

18 

Higgins JPT, Altman DJ and Sterne JAC: Chapter 8: Assessing risk of bias in included studies. Higgins JPT and Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration. 2011, http://www.cochrane-handbook.org

19 

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P and Schünemann HJ; GRADE, : Working Group: GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 336:924–926. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

21 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Ikeda M, Mori E, Matsuo K, Nakagawa M and Kosaka K: Donepezil for dementia with Lewy bodies: A randomized, placebo-controlled, confirmatory phase III trial. Alzheimers Res Ther. 7:42015. View Article : Google Scholar : PubMed/NCBI

23 

Mori E, Ikeda M and Kosaka K: Donepezil-DLB Study Investigators: Donepezil for dementia with Lewy bodies: A randomized, placebo-controlled trial. Ann Neurol. 72:41–52. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Aarsland D, Laake K, Larsen JP and Janvin C: Donepezil for cognitive impairment in Parkinson's disease: A randomised controlled study. J Neurol Neurosurg Psychiatry. 72:708–712. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Dubois B, Tolosa E, Katzenschlager R, Emre M, Lees AJ, Schumann G, Pourcher E, Gray J, Thomas G, Swartz J, et al: Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study. Mov Disord. 27:1230–1238. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Leroi I, Brandt J, Reich SG, Lyketsos CG, Grill S, Thompson R and Marsh L: Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease. Int J Geriatr Psychiatry. 19:1–8. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ravina B, Putt M, Siderowf A, Farrar JT, Gillespie M, Crawley A, Fernandez HH, Trieschmann MM, Reichwein S and Simuni T: Donepezil for dementia in Parkinson's disease: A randomised, double blind, placebo controlled, crossover study. J Neurol Neurosurg Psychiatry. 76:934–939. 2005. View Article : Google Scholar : PubMed/NCBI

28 

McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R and Spiegel R: Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study. Lancet. 356:2031–2036. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Emre M, Aarsland D, Albanese A, Byrne EJ, Deuschl G, De Deyn PP, Durif F, Kulisevsky J, van Laar T, Lees A, et al: Rivastigmine for dementia associated with Parkinson's disease. N Engl J Med. 351:2509–2518. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Mamikonyan E, Xie SX, Melvin E and Weintraub D: Rivastigmine for mild cognitive impairment in Parkinson disease: A placebo-controlled study. Mov Disord. 30:912–918. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Wesnes KA, McKeith IG, Ferrara R, Emre M, Del Ser T, Spano PF, Cicin-Sain A, Anand R and Spiegel R: Effects of rivastigmine on cognitive function in dementia with lewy bodies: A randomised placebo-controlled international study using the cognitive drug research computerised assessment system. Dement Geriatr Cogn Disord. 13:183–192. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Leroi I, Overshott R, Byrne EJ, Daniel E and Burns A: Randomized controlled trial of memantine in dementia associated with Parkinson's disease. Mov Disord. 24:1217–1221. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Aarsland D, Ballard C, Walker Z, Bostrom F, Alves G, Kossakowski K, Leroi I, Pozo-Rodriguez F, Minthon L and Londos E: Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: A double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 8:613–618. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Emre M, Tsolaki M, Bonuccelli U, Destée A, Tolosa E, Kutzelnigg A, Ceballos-Baumann A, Zdravkovic S, Bladström A and Jones R; 11018 Study Investigators, : Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: A randomised, double-blind, placebo-controlled trial. Lancet Neurol. 9:969–977. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Stubendorff K, Larsson V, Ballard C, Minthon L, Aarsland D and Londos E: Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: A prospective study. BMJ Open. 4:e0051582014. View Article : Google Scholar : PubMed/NCBI

36 

Manabe Y, Ino T, Yamanaka K and Kosaka K: Increased dosage of donepezil for the management of behavioural and psychological symptoms of dementia in dementia with Lewy bodies. Psychogeriatrics. 16:202–208. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Mori E, Ikeda M, Nakai K, Miyagishi H, Nakagawa M and Kosaka K: Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial. J Neurol Sci. 366:184–190. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ukai K, Fujishiro H, Iritani S and Ozaki N: Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies. Psychogeriatrics. 15:133–137. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Litvinenko IV, Odinak MM, Mogil'naya VI and Emelin AY: Efficacy and safety of galantamine (reminyl) for dementia in patients with Parkinson's disease (an open controlled trial). Neurosci Behav Physiol. 38:937–945. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Larsson V, Aarsland D, Ballard C, Minthon L and Londos E: The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia. Int J Geriatr Psychiatry. 25:1030–1038. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Emre M, Poewe W, De Deyn PP, Barone P, Kulisevsky J, Pourcher E, van Laar T, Storch A, Micheli F, Burn D, et al: Long-term safety of rivastigmine in parkinson disease dementia: An open-label, randomized study. Clin Neuropharmacol. 37:9–16. 2014.PubMed/NCBI

42 

Sherman DS, Mauser J, Nuno M and Sherzai D: The efficacy of cognitive intervention in mild cognitive impairment (MCI): A meta-analysis of outcomes on neuropsychological measures. Neuropsychol Rev. 27:440–484. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng YH, Wang PP, Song YX and Wang JH: Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis. Exp Ther Med 17: 1611-1624, 2019.
APA
Meng, Y., Wang, P., Song, Y., & Wang, J. (2019). Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis. Experimental and Therapeutic Medicine, 17, 1611-1624. https://doi.org/10.3892/etm.2018.7129
MLA
Meng, Y., Wang, P., Song, Y., Wang, J."Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis". Experimental and Therapeutic Medicine 17.3 (2019): 1611-1624.
Chicago
Meng, Y., Wang, P., Song, Y., Wang, J."Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1611-1624. https://doi.org/10.3892/etm.2018.7129
Copy and paste a formatted citation
x
Spandidos Publications style
Meng YH, Wang PP, Song YX and Wang JH: Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis. Exp Ther Med 17: 1611-1624, 2019.
APA
Meng, Y., Wang, P., Song, Y., & Wang, J. (2019). Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis. Experimental and Therapeutic Medicine, 17, 1611-1624. https://doi.org/10.3892/etm.2018.7129
MLA
Meng, Y., Wang, P., Song, Y., Wang, J."Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis". Experimental and Therapeutic Medicine 17.3 (2019): 1611-1624.
Chicago
Meng, Y., Wang, P., Song, Y., Wang, J."Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta‑analysis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1611-1624. https://doi.org/10.3892/etm.2018.7129
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