MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

  • Authors:
    • Xinde Hu
    • Yifeng Liu
    • Ping Ai
    • Shuguang He
    • Lingzhi Liu
    • Chaoying Chen
    • Yuansheng Tan
    • Ting Wang
  • View Affiliations

  • Published online on: January 7, 2019     https://doi.org/10.3892/etm.2019.7154
  • Pages: 1930-1938
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Abstract

MicroRNAs (miRs), a class of small non‑coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR‑186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously. In the present study, the expression of miR‑186 was significantly increased in CSCC tissues compared with adjacent non‑tumour tissues. Overexpression of miR‑186 significantly promoted CSCC cell proliferation while inhibiting cell apoptosis. Reticulophagy regulator 1 (RETREG1), a gene that is significantly downregulated in CSCC tissues and cell lines, was identified as a novel target of miR‑186. In addition, the expression of RETREG1 was inversely correlated with miR‑186 expression in CSCC tissues. Furthermore, the expression of RETREG1 was negatively regulated by miR‑186 in CSCC cells, and restoration of RETREG1 attenuated the effects of miR‑186 on CSCC cells. Taken together, the results of the current study suggest that miR‑186 serves an oncogenic role in CSCC and may be used as a potential therapeutic target for the treatment of this disease.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hu X, Liu Y, Ai P, He S, Liu L, Chen C, Tan Y and Wang T: MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med 17: 1930-1938, 2019
APA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C. ... Wang, T. (2019). MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Experimental and Therapeutic Medicine, 17, 1930-1938. https://doi.org/10.3892/etm.2019.7154
MLA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17.3 (2019): 1930-1938.
Chicago
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1930-1938. https://doi.org/10.3892/etm.2019.7154