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Article

MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

  • Authors:
    • Xinde Hu
    • Yifeng Liu
    • Ping Ai
    • Shuguang He
    • Lingzhi Liu
    • Chaoying Chen
    • Yuansheng Tan
    • Ting Wang
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Department of Dermatology, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Department of General Surgery, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Clinical Laboratory, First Affiliated Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan 412000, P.R. China, Hanpu Science and Teaching Park, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
  • Pages: 1930-1938
    |
    Published online on: January 7, 2019
       https://doi.org/10.3892/etm.2019.7154
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Abstract

MicroRNAs (miRs), a class of small non‑coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR‑186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously. In the present study, the expression of miR‑186 was significantly increased in CSCC tissues compared with adjacent non‑tumour tissues. Overexpression of miR‑186 significantly promoted CSCC cell proliferation while inhibiting cell apoptosis. Reticulophagy regulator 1 (RETREG1), a gene that is significantly downregulated in CSCC tissues and cell lines, was identified as a novel target of miR‑186. In addition, the expression of RETREG1 was inversely correlated with miR‑186 expression in CSCC tissues. Furthermore, the expression of RETREG1 was negatively regulated by miR‑186 in CSCC cells, and restoration of RETREG1 attenuated the effects of miR‑186 on CSCC cells. Taken together, the results of the current study suggest that miR‑186 serves an oncogenic role in CSCC and may be used as a potential therapeutic target for the treatment of this disease.
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1 

Gordon R: Skin cancer: An overview of epidemiology and risk factors. Semin Oncol Nurs. 29:160–169. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Linares MA, Zakaria A and Nizran P: Skin cancer. Prim Care. 42:645–659. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Prieto-Granada C and Rodriguez-Waitkus P: Cutaneous squamous cell carcinoma and related entities: Epidemiology, clinical and histological features, and basic science overview. Curr Probl Cancer. 39:206–215. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Burton KA, Ashack KA and Khachemoune A: Cutaneous squamous cell carcinoma: A review of high-risk and metastatic disease. Am J Clin Dermatol. 17:491–508. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Farazi TA, Hoell JI, Morozov P and Tuschl T: MicroRNAs in human cancer. Adv Exp Med Biol. 774:1–20. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Bai X, Zhou Y, Chen P, Yang M and Xu J: MicroRNA-142-5p induces cancer stem cell-like properties of cutaneous squamous cell carcinoma via inhibiting PTEN. J Cell Biochem. 119:2179–2188. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lin N, Zhou Y, Lian X and Tu Y: MicroRNA-31 functions as an oncogenic microRNA in cutaneous squamous cell carcinoma cells by targeting RhoTBT1. Oncol Lett. 13:1078–1082. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Zhou M, Zhou L, Zheng L, Guo L, Wang Y, Liu H, Ou C and Ding Z: miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB). PLoS One. 9:e1006202014. View Article : Google Scholar : PubMed/NCBI

11 

Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grandér D, Ståhle M, Sonkoly E and Pivarcsi A: MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion. J Biol Chem. 287:29899–29908. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Lin J, Ma JC, Yang J, Yin JY, Chen XX, Guo H, Wen XM, Zhang TJ, Qian W, Qian J and Deng ZQ: Arresting of miR-186 and releasing of H19 by DDX43 facilitate tumorigenesis and CML progression. Oncogene. 37:2432–2443. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Li J, Xia L, Zhou Z, Zuo Z, Xu C, Song H and Cai J: MiR-186-5p upregulation inhibits proliferation, metastasis and epithelial-to-mesenchymal transition of colorectal cancer cell by targeting ZEB1. Arch Biochem Biophys. 640:53–60. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Nishida T, Kanda T, Hasegawa T, et al: Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors. Oncol Lett. 14:5703–5710. 2017.PubMed/NCBI

15 

Huang T, Wang G, Yang L, Peng B, Wen Y, Ding G and Wang Z: MiR-186 inhibits proliferation, migration, and invasion of non-small cell lung cancer cells by downregulating Yin Yang 1. Cancer Biomark. 21:221–228. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Gou Y, Zhai F, Zhang L and Cui L: RUNX3 regulates hepatocellular carcinoma cell metastasis via targeting miR-186/E-cadherin/EMT pathway. Oncotarget. 8:61475–61486. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Zhang JJ, Wang DD, Du CX and Wang Y: Long noncoding RNA ANRIL promotes cervical cancer development by acting as a sponge of miR-186. Oncol Res. 26:345–352. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Liu L, Wang Y, Bai R, Yang K and Tian Z: MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation. Oncogenesis. 5:e2242016. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Zhou L, Gao R, Wang Y, Zhou M and Ding Z: Loss of BAX by miR-365 promotes cutaneous squamous cell carcinoma progression by suppressing apoptosis. Int J Mol Sci. 18:E11572017. View Article : Google Scholar : PubMed/NCBI

21 

Stojadinovic O, Ramirez H, Pastar I, Gordon KA, Stone R, Choudhary S, Badiavas E, Nouri K and Tomic-Canic M: MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. Arch Dermatol Res. 309:133–139. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Wang S, Cao KE, He Q, Yin Z and Zhou J: miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma. Oncol Lett. 12:97–101. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Canueto J, Cardenoso-Alvarez E, Garcia-Hernandez JL, Galindo-Villardón P, Vicente-Galindo P, Vicente-Villardón JL, Alonso-López D, De Las Rivas J, Valero J, Moyano-Sanz E, et al: MicroRNA (miR)-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma. Br J Dermatol. 177:168–178. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Cai Z, Hao XY and Liu FX: MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. Arch Oral Biol. 89:20–25. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Ruan L, Chen J, Ruan L, Yang T and Wang P: MicroRNA-186 suppresses lung cancer progression by targeting SIRT6. Cancer Biomark. 21:415–423. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Islam F, Gopalan V and Lam AK: RETREG1 (FAM134B): A new player in human diseases: 15 years after the discovery in cancer. J Cell Physiol. 233:4479–4489. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Kasem K, Gopalan V, Salajegheh A, Lu CT, Smith RA and Lam AK: The roles of JK-1 (FAM134B) expressions in colorectal cancer. Exp Cell Res. 326:166–173. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Islam F, Gopalan V, Pillai S, Lu CT, Kasem K and Lam AK: Promoter hypermethylation inactivate tumor suppressor FAM134B and is associated with poor prognosis in colorectal cancer. Genes Chromosomes Cancer. 57:240–251. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Islam F, Gopalan V, Wahab R, Smith RA, Qiao B and Lam AK: Stage dependent expression and tumor suppressive function of FAM134B (JK1) in colon cancer. Mol Carcinog. 56:238–249. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Islam F, Gopalan V, Vider J, Wahab R, Ebrahimi F, Lu CT, Kasem K and Lam AKY: MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor. Exp Cell Res. 357:260–270. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu X, Liu Y, Ai P, He S, Liu L, Chen C, Tan Y and Wang T: MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med 17: 1930-1938, 2019.
APA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C. ... Wang, T. (2019). MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Experimental and Therapeutic Medicine, 17, 1930-1938. https://doi.org/10.3892/etm.2019.7154
MLA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17.3 (2019): 1930-1938.
Chicago
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1930-1938. https://doi.org/10.3892/etm.2019.7154
Copy and paste a formatted citation
x
Spandidos Publications style
Hu X, Liu Y, Ai P, He S, Liu L, Chen C, Tan Y and Wang T: MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Exp Ther Med 17: 1930-1938, 2019.
APA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C. ... Wang, T. (2019). MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1. Experimental and Therapeutic Medicine, 17, 1930-1938. https://doi.org/10.3892/etm.2019.7154
MLA
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17.3 (2019): 1930-1938.
Chicago
Hu, X., Liu, Y., Ai, P., He, S., Liu, L., Chen, C., Tan, Y., Wang, T."MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1930-1938. https://doi.org/10.3892/etm.2019.7154
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