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VEGF and sFLT-1 in serum of PIH patients and effects on the foetus

  • Authors:
    • Yanhong Tang
    • Wenfeng Ye
    • Xia Liu
    • Yan Lv
    • Changfang Yao
    • Jiang Wei
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China, Comprehensive Laboratory, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China
  • Pages: 2123-2128
    |
    Published online on: January 18, 2019
       https://doi.org/10.3892/etm.2019.7184
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Abstract

The expression of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) in the serum of patients with pregnancy induced hypertension (PIH) syndrome and its effects on the foetus was explored. A total of 105 cases of PIH pregnant women admitted to The First People's Hospital of Changzhou from March 2015 to February 2018 were divided into 3 groups according to the severity of the patient's condition. Group A (n=35) was hypertension complicating pregnancy, group B (n=46) was mild preeclampsia and group C (n=24) was severe preeclampsia. In addition, 35 healthy pregnant women were selected as the control group. VEGF and sFLT-1 levels in serum were detected by enzyme linked immunosorbent assay, and the correlations between levels of VEGF and sFLT-1, neonatal weight and Apgar score were analyzed. Compared with group A, the level of serum VEGF was lower, while the level of sFLT-1 was higher in groups B and C (P<0.05). Compared with group B, the serum VEGF level in group C decreased significantly (P<0.05), while the serum level of sFLT-1 increased significantly (P<0.05). Compared with group A, neonatal weight and Apgar score in group C was significantly lower (P<0.05). There was a positive correlation between the serum VEGF level and neonatal weight and Apgar score (r=0.435, P<0.001. r=0.357, P<0.001). There was a negative correlation between the serum sFLT-1 level and neonatal weight and Apgar score (r=-0.351, P<0.001. r=-0.422, P<0.001). Therefore, we concluded that VEGF and sFlt-1 may be involved in the occurrence and development of PIH. The decrease of serum VEGF level and the increase of sFlt-1 level may be related to the inhibited fetal growth and development, which is of great significance in the clinical detection of PIH patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tang Y, Ye W, Liu X, Lv Y, Yao C and Wei J: VEGF and sFLT-1 in serum of PIH patients and effects on the foetus. Exp Ther Med 17: 2123-2128, 2019.
APA
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., & Wei, J. (2019). VEGF and sFLT-1 in serum of PIH patients and effects on the foetus. Experimental and Therapeutic Medicine, 17, 2123-2128. https://doi.org/10.3892/etm.2019.7184
MLA
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., Wei, J."VEGF and sFLT-1 in serum of PIH patients and effects on the foetus". Experimental and Therapeutic Medicine 17.3 (2019): 2123-2128.
Chicago
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., Wei, J."VEGF and sFLT-1 in serum of PIH patients and effects on the foetus". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2123-2128. https://doi.org/10.3892/etm.2019.7184
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Y, Ye W, Liu X, Lv Y, Yao C and Wei J: VEGF and sFLT-1 in serum of PIH patients and effects on the foetus. Exp Ther Med 17: 2123-2128, 2019.
APA
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., & Wei, J. (2019). VEGF and sFLT-1 in serum of PIH patients and effects on the foetus. Experimental and Therapeutic Medicine, 17, 2123-2128. https://doi.org/10.3892/etm.2019.7184
MLA
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., Wei, J."VEGF and sFLT-1 in serum of PIH patients and effects on the foetus". Experimental and Therapeutic Medicine 17.3 (2019): 2123-2128.
Chicago
Tang, Y., Ye, W., Liu, X., Lv, Y., Yao, C., Wei, J."VEGF and sFLT-1 in serum of PIH patients and effects on the foetus". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2123-2128. https://doi.org/10.3892/etm.2019.7184
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