VEGF and sFLT-1 in serum of PIH patients and effects on the foetus

Tang,Yanhong; Ye,Wenfeng; Liu,Xia; Lv,Yan; Yao,Changfang; Wei,Jiang

doi:10.3892/etm.2019.7184

VEGF and sFLT-1 in serum of PIH patients and effects on the foetus

Authors:
- Yanhong Tang
- Wenfeng Ye
- Xia Liu
- Yan Lv
- Changfang Yao
- Jiang Wei
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Affiliations: Department of Gynaecology and Obstetrics, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China, Comprehensive Laboratory, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China
Published online on: January 18, 2019 https://doi.org/10.3892/etm.2019.7184
Pages: 2123-2128

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Abstract

The expression of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) in the serum of patients with pregnancy induced hypertension (PIH) syndrome and its effects on the foetus was explored. A total of 105 cases of PIH pregnant women admitted to The First People's Hospital of Changzhou from March 2015 to February 2018 were divided into 3 groups according to the severity of the patient's condition. Group A (n=35) was hypertension complicating pregnancy, group B (n=46) was mild preeclampsia and group C (n=24) was severe preeclampsia. In addition, 35 healthy pregnant women were selected as the control group. VEGF and sFLT-1 levels in serum were detected by enzyme linked immunosorbent assay, and the correlations between levels of VEGF and sFLT-1, neonatal weight and Apgar score were analyzed. Compared with group A, the level of serum VEGF was lower, while the level of sFLT-1 was higher in groups B and C (P<0.05). Compared with group B, the serum VEGF level in group C decreased significantly (P<0.05), while the serum level of sFLT-1 increased significantly (P<0.05). Compared with group A, neonatal weight and Apgar score in group C was significantly lower (P<0.05). There was a positive correlation between the serum VEGF level and neonatal weight and Apgar score (r=0.435, P<0.001. r=0.357, P<0.001). There was a negative correlation between the serum sFLT-1 level and neonatal weight and Apgar score (r=-0.351, P<0.001. r=-0.422, P<0.001). Therefore, we concluded that VEGF and sFlt-1 may be involved in the occurrence and development of PIH. The decrease of serum VEGF level and the increase of sFlt-1 level may be related to the inhibited fetal growth and development, which is of great significance in the clinical detection of PIH patients.

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