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Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice

  • Authors:
    • Mingwei Xu
    • Hongbo Shi
    • Dongcao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2256-2262
    |
    Published online on: January 21, 2019
       https://doi.org/10.3892/etm.2019.7189
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Abstract

Renal ischemia reperfusion (IR) is a major cause of acute kidney injury with no effective treatment. Chrysin is an anti‑inflammatory, anti‑oxidant and anti‑cancer agent. However, the effect of chrysin on renal IR injury remains unknown. In this study, sham operation, IR and IR+chrysin group mice were treated with or without renal IR injury. For renal IR, bilateral renal pedicles were clamped for 30 min and then released for 48 h of reperfusion. Blood and kidney samples were collected for analysis. Results demonstrated that chrysin pretreatment remarkably decreased the levels of serum creatinine and blood urea nitrogen and attenuated morphological abnormalities in renal IR injury. Consistently, tubular cell apoptosis and inflammation were more attenuated in the chrysin pretreatment group compared with the IR group. Chrysin pretreatment decreased the expression of Bax and cleaved caspase‑3 and increased the expression of Bcl‑2 in renal IR injury. Furthermore, chrysin administration decreased the mRNA and protein levels of tumor necrosis factor‑α, interleukin (IL)‑1β, and IL‑6. Furthermore, the IκBα/nuclear factor‑κB signaling pathway was more suppressed in the chrysin pretreatment group compared with the IR group. In conclusion, chrysin protects against tubular cell apoptosis and inflammation in renal IR injury.
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1 

Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, et al: Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice. Nat Med. 22:183–193. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H and Reeves WB: Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury. Kidney Int. 93:365–374. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Rabadi M, Kim M, D'Agati V and Lee HT: Peptidyl arginine deiminase-4-deficient mice are protected against kidney and liver injury after renal ischemia and reperfusion. Am J Physiol Renal Physiol. 311:F437–F449. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chen H, Wang L, Wang W, Cheng C, Zhang Y, Zhou Y, Wang C, Miao X, Wang J, Wang C, et al: ELABELA and an ELABELA fragment protect against AKI. J Am Soc Nephrol. 28:2694–2707. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Qin C, Xiao C, Su Y, Zheng H, Xu T, Lu J, Luo P and Zhang J: Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells. Exp Cell Res. 359:138–144. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V and Bonventre JV: KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 125:1620–1636. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Deldar Y, Pilehvar-Soltanahmadi Y, Dadashpour M, Montazer Saheb S, Rahmati-Yamchi M and Zarghami N: An in vitro examination of the antioxidant, cytoprotective and anti-inflammatory properties of chrysin-loaded nanofibrous mats for potential wound healing applications. Artif Cells Nanomed Biotechnol. 46:706–716. 2018. View Article : Google Scholar : PubMed/NCBI

8 

George MY, Esmat A, Tadros MG and El-Demerdash E: In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesis. Eur J Pharmacol. 818:486–498. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Sassi A, Maatouk M, El GD, Bzéouich IM, Abdelkefi-Ben HS, Jemni-Yacoub S, Ghedira K and Chekir-Ghedira L: Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and in vivo study. Chem Biol Interact. 283:10–19. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Yao Y, Chen L, Xiao J, Wang C, Jiang W, Zhang R and Hao J: Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation. Int J Mol Sci. 15:20913–20926. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Jia Y, Zhao J, Liu M, Li B, Song Y, Li Y, Wen A and Shi L: Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway. Int J Mol Med. 38:210–216. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Dominguez JH, Liu Y, Gao H, Dominguez JN, Xie D and Kelly KJ: Renal tubular cell-derived extracellular vesicles accelerate the recovery of established renal ischemia reperfusion injury. J Am Soc Nephrol. 28:3533–3544. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Yuan X, Wang X, Chen C, Zhou J and Han M: Bone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223. Stem Cell Res Ther. 8:1462017. View Article : Google Scholar : PubMed/NCBI

15 

Ramirez-Espinosa JJ, Saldana-Rios J, Garcia-Jimenez S, Villalobos-Molina R, Avila-Villarreal G, Rodriguez-Ocampo AN, Bernal-Fernandez G and Estrada-Soto S: Chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice. Molecules. 23:672017. View Article : Google Scholar

16 

Choi JK, Jang YH, Lee S, Lee SR, Choi YA, Jin M, Choi JH, Park JH, Park PH, Choi H, et al: Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes. Food Chem Toxicol. 110:142–150. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Missassi G, Dos Santos Borges C, de Lima J, Villela E, Silva P, da Cunha Martins A Jr, Barbosa F Jr and De Grava Kempinas W: Chrysin administration protects against oxidative damage in varicocele-induced adult rats. Oxid Med Cell Longev. 2017:21729812017. View Article : Google Scholar : PubMed/NCBI

18 

Lim W, Ryu S, Bazer FW, Kim SM and Song G: Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. J Cell Physiol. 233:3129–3140. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Zhou Y, Cai T, Xu J, Jiang L, Wu J, Sun Q, Zen K and Yang J: UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 313:F926–F937. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Choi DE, Jeong JY, Choi H, Chang YK, Ahn MS, Ham YR, Na KR and Lee KW: ERK phosphorylation plays an important role in the protection afforded by hypothermia against renal ischemia-reperfusion injury. Surgery. 161:444–452. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Mu Y, Zhou X, Ji H, Gao X, Cai WW, Guan Q and Xu T: SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion. Apoptosis. 22:519–530. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Y, Hu F, Wen J, Wei X, Zeng Y, Sun Y, Luo S and Sun L: Effects of sevoflurane on NF-кB and TNF-α expression in renal ischemia-reperfusion diabetic rats. Inflamm Res. 66:901–910. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Raup-Konsavage WM, Gao T, Cooper TK, Morris SJ Jr, Reeves WB and Awad AS: Arginase-2 mediates renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 313:F522–F534. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu M, Shi H and Liu D: Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Exp Ther Med 17: 2256-2262, 2019.
APA
Xu, M., Shi, H., & Liu, D. (2019). Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Experimental and Therapeutic Medicine, 17, 2256-2262. https://doi.org/10.3892/etm.2019.7189
MLA
Xu, M., Shi, H., Liu, D."Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice". Experimental and Therapeutic Medicine 17.3 (2019): 2256-2262.
Chicago
Xu, M., Shi, H., Liu, D."Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2256-2262. https://doi.org/10.3892/etm.2019.7189
Copy and paste a formatted citation
x
Spandidos Publications style
Xu M, Shi H and Liu D: Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Exp Ther Med 17: 2256-2262, 2019.
APA
Xu, M., Shi, H., & Liu, D. (2019). Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice. Experimental and Therapeutic Medicine, 17, 2256-2262. https://doi.org/10.3892/etm.2019.7189
MLA
Xu, M., Shi, H., Liu, D."Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice". Experimental and Therapeutic Medicine 17.3 (2019): 2256-2262.
Chicago
Xu, M., Shi, H., Liu, D."Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation in mice". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2256-2262. https://doi.org/10.3892/etm.2019.7189
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