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Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis

  • Authors:
    • Hongyan Li
    • Yuexia Xu
    • Qin Zhang
    • Hongfang Xu
    • Yan Xu
    • Kai Ling
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First People's Hospital of Wujiang, Wujiang Hospital Affiliated to Nantong University, Suzhou, Jiangsu 215200, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2310-2316
    |
    Published online on: January 24, 2019
       https://doi.org/10.3892/etm.2019.7197
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Abstract

Function and potential mechanism of microvesicles (MVs) containing microRNA34a in renal interstitial fibrosis were investigated. A rat model of renal interstitial fibrosis was established by unilateral ureteral ligation (UUO).Rat proximal tubular epithelial cell line (NRK-52E) was used to explore the effect of MVs containing microRNA-34a on tubular epithelial cells during fibrosis, which were secreted by tubulointerstitial fibroblasts. Regardless of the UUO renal interstitial fibrosis model, or the TGF-β1-treated renal tubular epithelial cells, microRNA-34a was increased in the MVs secreted by tubulointerstitial fibroblasts. miR-34a could be transmitted through the damaged tubule basement membrane to proximal tubular epithelial cells, where it induced apoptosis of renal tubular epithelial cells by inhibiting the expression of Bcl-2, further aggravating renal interstitial fibrosis. MicroRNA-34a secreted by damaged renal interstitial fibroblasts can promote renal tubular epithelial cell apoptosis and participate in renal interstitial fibrosis by inhibiting Bcl-2.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Xu Y, Zhang Q, Xu H, Xu Y and Ling K: Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis. Exp Ther Med 17: 2310-2316, 2019.
APA
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., & Ling, K. (2019). Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis. Experimental and Therapeutic Medicine, 17, 2310-2316. https://doi.org/10.3892/etm.2019.7197
MLA
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., Ling, K."Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis". Experimental and Therapeutic Medicine 17.3 (2019): 2310-2316.
Chicago
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., Ling, K."Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2310-2316. https://doi.org/10.3892/etm.2019.7197
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Xu Y, Zhang Q, Xu H, Xu Y and Ling K: Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis. Exp Ther Med 17: 2310-2316, 2019.
APA
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., & Ling, K. (2019). Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis. Experimental and Therapeutic Medicine, 17, 2310-2316. https://doi.org/10.3892/etm.2019.7197
MLA
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., Ling, K."Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis". Experimental and Therapeutic Medicine 17.3 (2019): 2310-2316.
Chicago
Li, H., Xu, Y., Zhang, Q., Xu, H., Xu, Y., Ling, K."Microvesicles containing miR-34a induce apoptosis of proximal tubular epithelial cells and participate in renal interstitial fibrosis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2310-2316. https://doi.org/10.3892/etm.2019.7197
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