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Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway

  • Authors:
    • Ayuka Mineda
    • Masato Nishimura
    • Tomohiro Kagawa
    • Eri Takiguchi
    • Takako Kawakita
    • Akiko Abe
    • Minoru Irahara
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770‑8503, Japan
    Copyright: © Mineda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2242-2246
    |
    Published online on: January 28, 2019
       https://doi.org/10.3892/etm.2019.7209
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Abstract

Resveratrol, a natural product and peroxisome proliferator-activated receptor (PPAR) agonist, has been reported to exert anti‑cancer effects in several tumor models. A previous study by our group reported that prostaglandin J2, a PPARγ ligand, inhibited cell proliferation in a uterine sarcoma cell line. The aim of the present study was to investigate the role of the Wnt signaling pathway in resveratrol‑induced apoptosis and inhibition of cell proliferation in the MES‑SA human uterine sarcoma cell line. A WST‑1 assay demonstrated that resveratrol inhibited cell proliferation in the MES‑SA cell line, and flow cytometry revealed that the number of apoptotic cells increased in a resveratrol dose‑dependent manner. The mechanisms underlying these effects of resveratrol were speculated to involve the expression of β‑catenin and its target gene, c‑myc, which were examined using western blot analysis. The results revealed a dose‑dependent downregulation of this β‑catenin and c‑myc. This effect was blunted by a pharmacological inhibitor of glycogen synthase kinase 3β. Therefore, it is likely that resveratrol inhibited the cell proliferation and increased the number of apoptotic cells, at least partially, via the Wnt signaling pathway. The present results suggest that resveratrol is a potential candidate for the treatment of uterine sarcoma.
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1 

Tsukamoto T, Nakata R, Tamura E, Kosuge Y, Kariya A, Katsukawa M, Mishima S, Ito T, Iinuma M, Akao Y, et al: Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivo. Nutr Metab (Lond). 7:462010. View Article : Google Scholar : PubMed/NCBI

2 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218–220. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Logan CY and Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 20:781–810. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Kawakita T, Masato N, Takiguchi E, Abe A and Irahara M: Cytotoxic effects of 15-deoxy-Δ12,14-prostaglandin J2 alone and in combination with dasatinib against uterine sarcoma in vitro. Exp Ther Med. 13:2939–2945. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Dai H, Deng HB, Wang YH and Guo JJ: Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway. Oncol Lett. 16:1579–1583. 2018.PubMed/NCBI

6 

Cilibrasi C, Riva G, Romano G, Cadamuro M, Bazzoni R, Butta V, Paoletta L, Dalprà L, Strazzabosco M, Lavitrano M, et al: Resveratrol impairs glioma stem cells proliferation and motility by modulating the Wnt signaling pathway. PLoS One. 12:e01698542017. View Article : Google Scholar : PubMed/NCBI

7 

Vanamala J, Reddivari L, Radhakrishnan S and Tarver C: Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 10:2382010. View Article : Google Scholar : PubMed/NCBI

8 

Hope C, Planutis K, Planutiene M, Moyer MP, Johal KS, Woo J, Santoso C, Hanson JA and Holcombe RF: Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: Implications for colon cancer prevention. Mol Nutr Food Res. 52 Suppl 1:S52–S61. 2008.PubMed/NCBI

9 

Guastalla JP, Bachelot T and Ray-Coquard I: Cyclooxygenase 2 and breast cancer. From biological concepts to clinical trials. Bull Cancer. 91 (Suppl 2):S99–S108. 2004.(In French).

10 

Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C and Holcombe RF: Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 3:25–37. 2009.

11 

Kahn M: Can we safely target the WNT pathway? Nat Rev Drug Discov. 13:513–532. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kikuchi A: Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci. 94:225–229. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Yost C, Torres M, Miller JR, Huang E, Kimelman D and Moon RT: The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 15:1443–1454. 1996. View Article : Google Scholar

14 

Chen C, Zhao M, Tian A, Zhang X, Yao Z and Ma X: Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells. Oncotarget. 6:17570–17583. 2015.PubMed/NCBI

15 

Zou Y, Yang J and Jiang D: Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells. Mol Med Rep. 12:7221–7226. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Barker N and Clevers H: Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 5:997–1014. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Frankel EN, Waterhouse AL and Kinsella JE: Inhibition of human LDL oxidation by resveratrol. Lancet. 341:1103–1104. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Mehlig K, Skoog I, Guo X, Schütze M, Gustafson D, Waern M, Ostling S, Björkelund C and Lissner L: Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg. Am J Epidemiol. 15:684–691. 2008.

19 

Holcombe RF, Martinez M, Planutis K and Planutiene M: Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption. Nutr J. 14:622015. View Article : Google Scholar : PubMed/NCBI

20 

Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ, et al: Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev. 16:1246–1252. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Yu C, Shin YG, Chow A, Li Y, Kosmeder JW, Lee YS, Hirschelman WH, Pezzuto JM, Mehta RG and van Breemen RB: Human, rat, and mouse metabolism of resveratrol. Pharm Res. 19:1907–1914. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Wu ML, Li H, Yu LJ, Chen XY, Kong QY, Song X, Shu XH and Liu J: Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PLoS One. 9:e898062014. View Article : Google Scholar : PubMed/NCBI

23 

Carter LG, D'Orazio JA and Pearson KJ: Resveratrol and cancer: Focus on in vivo evidence. Endocr Relat Cancer. 21:R209–R225. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mineda A, Nishimura M, Kagawa T, Takiguchi E, Kawakita T, Abe A and Irahara M: Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway. Exp Ther Med 17: 2242-2246, 2019.
APA
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., & Irahara, M. (2019). Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway. Experimental and Therapeutic Medicine, 17, 2242-2246. https://doi.org/10.3892/etm.2019.7209
MLA
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., Irahara, M."Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway". Experimental and Therapeutic Medicine 17.3 (2019): 2242-2246.
Chicago
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., Irahara, M."Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2242-2246. https://doi.org/10.3892/etm.2019.7209
Copy and paste a formatted citation
x
Spandidos Publications style
Mineda A, Nishimura M, Kagawa T, Takiguchi E, Kawakita T, Abe A and Irahara M: Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway. Exp Ther Med 17: 2242-2246, 2019.
APA
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., & Irahara, M. (2019). Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway. Experimental and Therapeutic Medicine, 17, 2242-2246. https://doi.org/10.3892/etm.2019.7209
MLA
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., Irahara, M."Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway". Experimental and Therapeutic Medicine 17.3 (2019): 2242-2246.
Chicago
Mineda, A., Nishimura, M., Kagawa, T., Takiguchi, E., Kawakita, T., Abe, A., Irahara, M."Resveratrol suppresses proliferation and induces apoptosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2242-2246. https://doi.org/10.3892/etm.2019.7209
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