Open Access

Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy

  • Authors:
    • Qing Xiao
    • Fang‑Ling Zeng
    • Guo‑Yi Tang
    • Chun‑Yan Lei
    • Xian‑Xiang Zou
    • Xiao‑Le Liu
    • Bi‑Ling Peng
    • Shuang Qin
    • Hui‑Xian Li
  • View Affiliations

  • Published online on: January 31, 2019     https://doi.org/10.3892/etm.2019.7227
  • Pages: 2623-2631
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The success of a pregnancy relies on moderate trophoblast apoptosis. If the ‘inhibition‑induction’ balance of apoptosis is broken, a pathological pregnancy may occur. Galectin‑3 has an important role in numerous biological processes, including tumor cell apoptosis. However, the association between galectin‑3 and missed abortion (MA) has remained elusive. In the present study, the mRNA and protein expression levels of galectin‑3 in placental villi, and the apoptotic index of placental cells from patients with MA were assessed and compared with those in a normal spontaneous abortion group. The present study investigated the function of galectin‑3 in the process of MA and the possible association between placental apoptosis and galectin‑3 expression in MA patients. Furthermore, the role of galetin‑3 in patients with MA at different times (<4 and >4 weeks) was explored. The present study provided a potential mechanism of MA from a perspective of apoptosis and also provided potential therapeutic approaches to prevent MA.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xiao Q, Zeng FL, Tang GY, Lei CY, Zou XX, Liu XL, Peng BL, Qin S and Li HX: Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Exp Ther Med 17: 2623-2631, 2019
APA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X. ... Li, H. (2019). Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Experimental and Therapeutic Medicine, 17, 2623-2631. https://doi.org/10.3892/etm.2019.7227
MLA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17.4 (2019): 2623-2631.
Chicago
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2623-2631. https://doi.org/10.3892/etm.2019.7227