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Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy

  • Authors:
    • Qing Xiao
    • Fang‑Ling Zeng
    • Guo‑Yi Tang
    • Chun‑Yan Lei
    • Xian‑Xiang Zou
    • Xiao‑Le Liu
    • Bi‑Ling Peng
    • Shuang Qin
    • Hui‑Xian Li
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, The Eighth Affiliated Hospital, Sun Yat‑sen University, Shenzhen, Guangdong 518033, P.R. China, Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510627, P.R. China, Department of Research and Development, Guangdong Longsee Biomedical Corporation, Guangzhou, Guangdong 510663, P.R. China, Department of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510889, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2623-2631
    |
    Published online on: January 31, 2019
       https://doi.org/10.3892/etm.2019.7227
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Abstract

The success of a pregnancy relies on moderate trophoblast apoptosis. If the ‘inhibition‑induction’ balance of apoptosis is broken, a pathological pregnancy may occur. Galectin‑3 has an important role in numerous biological processes, including tumor cell apoptosis. However, the association between galectin‑3 and missed abortion (MA) has remained elusive. In the present study, the mRNA and protein expression levels of galectin‑3 in placental villi, and the apoptotic index of placental cells from patients with MA were assessed and compared with those in a normal spontaneous abortion group. The present study investigated the function of galectin‑3 in the process of MA and the possible association between placental apoptosis and galectin‑3 expression in MA patients. Furthermore, the role of galetin‑3 in patients with MA at different times (<4 and >4 weeks) was explored. The present study provided a potential mechanism of MA from a perspective of apoptosis and also provided potential therapeutic approaches to prevent MA.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao Q, Zeng FL, Tang GY, Lei CY, Zou XX, Liu XL, Peng BL, Qin S and Li HX: Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Exp Ther Med 17: 2623-2631, 2019.
APA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X. ... Li, H. (2019). Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Experimental and Therapeutic Medicine, 17, 2623-2631. https://doi.org/10.3892/etm.2019.7227
MLA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17.4 (2019): 2623-2631.
Chicago
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2623-2631. https://doi.org/10.3892/etm.2019.7227
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Q, Zeng FL, Tang GY, Lei CY, Zou XX, Liu XL, Peng BL, Qin S and Li HX: Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Exp Ther Med 17: 2623-2631, 2019.
APA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X. ... Li, H. (2019). Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Experimental and Therapeutic Medicine, 17, 2623-2631. https://doi.org/10.3892/etm.2019.7227
MLA
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17.4 (2019): 2623-2631.
Chicago
Xiao, Q., Zeng, F., Tang, G., Lei, C., Zou, X., Liu, X., Peng, B., Qin, S., Li, H."Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2623-2631. https://doi.org/10.3892/etm.2019.7227
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