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Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer

  • Authors:
    • Kang Liu
    • Min Kang
    • Jixi Li
    • Wen Qin
    • Rensheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2657-2665
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    Published online on: January 31, 2019
       https://doi.org/10.3892/etm.2019.7228
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Abstract

The aim of the present study was to investigate the potential prognostic value of members of the heat shock protein (HSP)90 family in non‑small cell lung cancer (NSCLC) patients. The mRNA expression profiles of 1,926 NSCLC patients, which was available from the Kaplan‑Meier plotter database, were included in the study. High expression of HSP90AA1 mRNA was significantly associated with a poorer rate of overall survival (OS) for all NSCLC patients [hazard ratio (HR), 1.21; 95% confidence interval (CI): 1.06‑1.37; P=0.004], as well as for patients with adenocarcinoma (ADE; HR, 1.3; 95% CI: 1.02‑1.65; P=0.034), but no significant correlation was identified for squamous cell carcinoma (SCC) patients (HR, 1.08; 95% CI: 0.85‑1.38; P=0.51). High expression of HSP90AB1 and HSP90B1 mRNA was significantly associated with poorer rates of OS in lung SCC and ADE patients combined, as well as in lung ADE patients alone. By contrast, high expression of tumor necrosis factor receptor‑associated protein 1 (TRAP1) mRNA was significantly associated with improved OS rates in all NSCLC patients combined (HR, 0.88; 95% CI: 0.77‑0.99; P=0.041), as well as ADE patients. In stratified survival analysis, a high expression of HSP90AA1, HSP90AB1 and HSP90B1 predicted poor prognosis in stage I NSLCC patients, suggesting that these genes may serve as stage‑independent prognostic indicators. As an elevated expression of HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 was associated with poorer OS outcomes in patients with NSCLC, these HSP90 members may be potential prognostic biomarkers and drug targets for the treatment of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu K, Kang M, Li J, Qin W and Wang R: Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer. Exp Ther Med 17: 2657-2665, 2019.
APA
Liu, K., Kang, M., Li, J., Qin, W., & Wang, R. (2019). Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer. Experimental and Therapeutic Medicine, 17, 2657-2665. https://doi.org/10.3892/etm.2019.7228
MLA
Liu, K., Kang, M., Li, J., Qin, W., Wang, R."Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer". Experimental and Therapeutic Medicine 17.4 (2019): 2657-2665.
Chicago
Liu, K., Kang, M., Li, J., Qin, W., Wang, R."Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2657-2665. https://doi.org/10.3892/etm.2019.7228
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Kang M, Li J, Qin W and Wang R: Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer. Exp Ther Med 17: 2657-2665, 2019.
APA
Liu, K., Kang, M., Li, J., Qin, W., & Wang, R. (2019). Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer. Experimental and Therapeutic Medicine, 17, 2657-2665. https://doi.org/10.3892/etm.2019.7228
MLA
Liu, K., Kang, M., Li, J., Qin, W., Wang, R."Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer". Experimental and Therapeutic Medicine 17.4 (2019): 2657-2665.
Chicago
Liu, K., Kang, M., Li, J., Qin, W., Wang, R."Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2657-2665. https://doi.org/10.3892/etm.2019.7228
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