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Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study

  • Authors:
    • Zheng Wu
    • Yi He
    • Wenzheng Li
    • Shujuan Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, P.R. China, Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2485-2494
    |
    Published online on: January 31, 2019
       https://doi.org/10.3892/etm.2019.7229
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Abstract

Patients with episodes of angina are likely to experience future cardiac events and benefit from a revascularization procedure. Conventional invasive coronary angiography is a well‑established and reliable method for the detection of angina, but it has a risk of complications and false‑negative diagnosis. The objective of the present study was to assess the utility of computed tomography coronary angiography (CTCA) in the diagnosis of angina due to coronary heart disease. A total of 2,426 patients with chest pain referred to the rapid access chest pain clinic of Beijing Anzhen Hospital, Capital Medical University (Beijing, P.R. China) between 18 January 2016 and 1 December 2017 were included in the present cross‑sectional study. All patients were subjected to evaluation of symptoms, blood tests, 12‑lead electrocardiogram (ECG), exercise ECG, coronary artery calcium scoring and CTCA. The cost of the diagnosis of angina was determined for each individual method. In total, 776 (32%) and 1,420 (58%) of patients were identified to be abnormal on clinical assessment and CTCA, respectively. Exercise ECG results were not correlated with the interpretation of CTCA (r=0.8511). The working area of the angina due to coronary heart disease detected at one time by the different diagnostic procedures was in the order of ECG <clinical assessment <exercise ECG <coronary artery calcium scoring <CTCA. The cost of the ‘standard diagnostic procedure (clinical assessments, ECG, exercise ECG)' was 15,452±806 ¥/patient and that of CTCA was 12,546±612 ¥/patient. CTCA had a higher sensitivity for the diagnosis of angina due to coronary heart disease and the cost was lower than that of the ‘standard diagnostic procedure’ (level of evidence: 3). The current study was registered at the Research Registry on 11th January 2016 (trial no. researchregistry4232).
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1 

Williams MC, Hunter A, Shah A, Assi V, Lewis S, Mangion K, Berry C, Boon NA, Clark E, Flather M, et al: Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: A randomised controlled trial. Heart. 103:995–1001. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Bennell MC, Qiu F, Kingsbury KJ, Austin PC and Wijeysundera HC: Determinants of variations in initial treatment strategies for stable ischemic heart disease. CMAJ. 187:E317–E325. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Jordan KP, Timmis A, Croft P, van der Windt DA, Denaxas S, González-Izquierdo A, Hayward RA, Perel P and Hemingway H: Prognosis of undiagnosed chest pain: Linked electronic health record cohort study. BMJ. 357:j11942017. View Article : Google Scholar : PubMed/NCBI

4 

Sekhri N, Feder GS, Junghans C, Hemingway H and Timmis AD: How effective are rapid access chest pain clinics? Prognosis of incident angina and non-cardiac chest pain in 8762 consecutive patients. Heart. 93:458–463. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Boyle RM: Value of rapid-access chest pain clinics. Heart. 93:415–416. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Parsonage WA, Cullen L and Younger JF: The approach to patients with possible cardiac chest pain. Med J Aust. 199:30–34. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP III, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O'Gara PT, et al: 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 70:252–289. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Sajjadieh A, Hekmatnia A, Keivani M, Asoodeh A, Pourmoghaddas M and Sanei H: Diagnostic performance of 64-row coronary CT angiography in detecting significant stenosis as compared with conventional invasive coronary angiography. ARYA Atheroscler. 9:157–163. 2013.PubMed/NCBI

9 

Dreisbach JG, Nicol ED, Roobottom CA, Padley S and Roditi G: Challenges in delivering computed tomography coronary angiography as the first-line test for stable chest pain. Heart. 104:921–927. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Mowatt G, Cummins E, Waugh N, Walker S, Cook J, Jia X, Hillis GS and Fraser C: Systematic review of the clinical effectiveness and cost-effectiveness of 64-slice or higher computed tomography angiography as an alternative to invasive coronary angiography in the investigation of coronary artery disease. Health Technol Assess. 12:iii–iv, ix-143. 2008. View Article : Google Scholar

11 

Fuchs TA, Stehli J, Bull S, Dougoud S, Clerc OF, Herzog BA, Buechel RR, Gaemperli O and Kaufmann PA: Coronary computed tomography angiography with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination. Eur Heart J. 35:1131–1136. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hamilton-Craig C, Fifoot A, Hansen M, Pincus M, Chan J, Walters DL and Branch KR: Diagnostic performance and cost of CT angiography versus stress ECG-a randomized prospective study of suspected acute coronary syndrome chest pain in the emergency department (CT-COMPARE). Int J Cardiol. 177:867–873. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Cohen JF, Korevaar DA, Altman DG, Bruns DE, Gatsonis CA, Hooft L, Irwig L, Levine D, Reitsma JB, de Vet HCW and Bossuyt PMM: STARD 2015 guidelines for reporting diagnostic accuracy studies: Explanation and elaboration. BMJ Open. 6:e0127992016. View Article : Google Scholar : PubMed/NCBI

14 

World Medical Association: World medical association declaration of helsinki: Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Arnold J, Goodacre S, Bath P and Price J: Information sheets for patients with acute chest pain: Randomised controlled trial. BMJ. 338:b5412009. View Article : Google Scholar : PubMed/NCBI

16 

Newby DE, Williams MC, Flapan AD, Forbes JF, Hargreaves AD, Leslie SJ, Lewis SC, McKillop G, McLean S, Reid JH, et al: Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: Study protocol for randomized controlled trial. Trials. 13:1842012. View Article : Google Scholar : PubMed/NCBI

17 

Timmis A and Roobottom CA: National institute for health and care excellence updates the stable chest pain guideline with radical changes to the diagnostic paradigm. Heart. 103:982–926. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Lennon SL, DellaValle DM, Rodder SG, Prest M, Sinley RC, Hoy MK and Papoutsakis C: 2015 Evidence analysis library evidence-based nutrition practice guideline for the management of hypertension in adults. J Acad Nutr Diet. 117:1445–1458.e17. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Kim KH, Jeon KN, Kang MG, Ahn JH, Koh JS, Park Y, Hwang SJ, Jeong YH, Kwak CH, Hwang JY and Park JR: Prognostic value of computed tomographic coronary angiography and exercise electrocardiography for cardiovascular events. Korean J Intern Med. 31:880–890. 2016. View Article : Google Scholar : PubMed/NCBI

20 

National Institute for Health and Clinical Excellence: Guidance: Chest pain of recent onset: Assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin [Internet]. National Clinical Guideline Centre for Acute and Chronic Conditions (UK). London Royal College of Physicians (UK); 2010

21 

Fitzgerald M, Saville BR and Lewis RJ: Decision curve analysis. JAMA. 313:409–410. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Blaha MJ, Budoff MJ, Tota-Maharaj R, Dardari ZA, Wong ND, Kronmal RA, Eng J, Post WS, Blumenthal RS and Nasir K: Improving the CAC score by addition of regional measures of calcium distribution: Multi-ethnic study of atherosclerosis. JACC Cardiovasc Imaging. 9:1407–1416. 2016. View Article : Google Scholar : PubMed/NCBI

23 

George RT, Arbab-Zadeh A, Miller JM, Kitagawa K, Chang HJ, Bluemke DA, Becker L, Yousuf O, Texter J, Lardo AC and Lima JA: Adenosine stress 64- and 256-row detector computed tomography angiography and perfusion imaging: A pilot study evaluating the transmural extent of perfusion abnormalities to predict atherosclerosis causing myocardial ischemia. Circ Cardiovasc Imaging. 2:174–182. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Holt T: Chest pain in primary care: What happens to the undiagnosed majority? BMJ. 357:j16262017. View Article : Google Scholar : PubMed/NCBI

25 

Xu Y, Tang L, Zhu X, Xu H, Tang J, Yang Z, Wang L and Wang D: Comparison of dual-source CT coronary angiography and conventional coronary angiography for detecting coronary artery disease. Int J Cardiovasc Imaging. 26 (Suppl 1):S75–S81. 2010. View Article : Google Scholar

26 

SCOT-HEART Investigators: CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): An open-label, parallel-group, multicentre trial. Lancet. 385:2383–2391. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Sabaté M and Ishida K: CT coronary angiography increase diagnostic certainty in patients with stable chest pain. Evid Based Med. 20:1872015. View Article : Google Scholar : PubMed/NCBI

28 

Boutron I, Moher D, Altman DG, Schulz KF and Ravaud P; CONSORT Group: Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: Explanation and elaboration. Ann Intern Med. 148:295–309. 2008. View Article : Google Scholar : PubMed/NCBI

29 

US and Food and Drug Administration. Step 3. Clinical research. https://www.fda.gov/ForPatients/Approvals/Drugs/ucm405622.htm15–October. 2016

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Copy and paste a formatted citation
Spandidos Publications style
Wu Z, He Y, Li W and Cheng S: Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study. Exp Ther Med 17: 2485-2494, 2019.
APA
Wu, Z., He, Y., Li, W., & Cheng, S. (2019). Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study. Experimental and Therapeutic Medicine, 17, 2485-2494. https://doi.org/10.3892/etm.2019.7229
MLA
Wu, Z., He, Y., Li, W., Cheng, S."Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study". Experimental and Therapeutic Medicine 17.4 (2019): 2485-2494.
Chicago
Wu, Z., He, Y., Li, W., Cheng, S."Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2485-2494. https://doi.org/10.3892/etm.2019.7229
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Z, He Y, Li W and Cheng S: Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study. Exp Ther Med 17: 2485-2494, 2019.
APA
Wu, Z., He, Y., Li, W., & Cheng, S. (2019). Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study. Experimental and Therapeutic Medicine, 17, 2485-2494. https://doi.org/10.3892/etm.2019.7229
MLA
Wu, Z., He, Y., Li, W., Cheng, S."Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study". Experimental and Therapeutic Medicine 17.4 (2019): 2485-2494.
Chicago
Wu, Z., He, Y., Li, W., Cheng, S."Computed tomography coronary angiography vs. standard diagnostic procedure for the diagnosis of angina due to coronary heart disease: A cross‑sectional study". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2485-2494. https://doi.org/10.3892/etm.2019.7229
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