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Article Open Access

Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors

  • Authors:
    • Haijun Sun
    • Xiuyun Zhang
    • Wei Shi
    • Bo Fang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Dongying People's Hospital, Dongying, Shandong 257000, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2535-2540
    |
    Published online on: February 1, 2019
       https://doi.org/10.3892/etm.2019.7232
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Abstract

Association of soft tissue infection in the extremity with glucose and lipid metabolism as well as inflammatory factors was investigated. One hundred and twenty-six patients with diabetes mellitus (DM) complicated with soft tissue infection in the lower extremity admitted and treated in Dongying People's Hospital from March 2016 to February 2017 were selected and divided into mild (n=46), moderate (n=43) and severe group (n=37) according to the severity of the soft tissue infection in the lower extremity. The glucose and lipid metabolism, inflammatory factors and influencing factors were compared among different groups of patients before treatment, and the changes in glucose and lipid metabolism as well as inflammatory factors were observed after treatment. Before treatment, the levels of free fatty acid (FFA), fasting plasma glucose (FPG), fasting insulin (FINS), vascular cell adhesion molecule-1 (VCAM-1), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in mild group were remarkably lower than those in moderate and severe groups, while the serum adiponectin (APN) level was obviously higher (P<0.05). Logistic regression analysis indicated that FFA, FPG, FINS, APN, VCAM-1, CRP, TNF-α and IL-6 were risk factors influencing soft tissue infection in the extremity (P<0.05). After treatment, among the 126 patients, the levels of FFA, FPG, FINS, VCAM-1, CRP, TNF-α and IL-6 were decreased markedly, while the APN level was increased evidently (P<0.05). Compared with patients innon‑toe/extremity amputation group, patients in toe/extremity amputation group had elevated levels of FFA, FPG, FINS, VCAM-1, CRP, TNF-α and IL-6 as well as declined APN level (P<0.05). Glucose and lipid metabolism and inflammatory factors are closely related to soft tissue infection in the extremity.
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1 

Rossi G; American Diabetes Association: Diagnosis and classification of diabetes mellitus. Recenti Prog Med. 101:274–276. 2010.(In Italian). PubMed/NCBI

2 

Colagiuri S: Glycated haemoglobin (HbA1c) for the diagnosis of diabetes mellitus - practical implications. Diabetes Res Clin Pract. 93:312–313. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Al-Rubeaan K, Al Derwish M, Ouizi S, Youssef AM, Subhani SN, Ibrahim HM and Alamri BN: Diabetic foot complications and their risk factors from a large retrospective cohort study. PLoS One. 10:e01244462015. View Article : Google Scholar : PubMed/NCBI

4 

Klenerman L, McCabe C, Cogley D, Crerand S, Laing P and White M: Screening for patients at risk of diabetic foot ulceration in a general diabetic outpatient clinic. Diabet Med. 13:561–563. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Lavigne JP, Sotto A, Dunyach-Remy C and Lipsky BA: New molecular techniques to study the skin microbiota of diabetic foot ulcers. Adv Wound Care (New Rochelle). 4:38–49. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hingorani A, LaMuraglia GM, Henke P, Meissner MH, Loretz L, Zinszer KM, Driver VR, Frykberg R, Carman TL, Marston W, et al: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. J Vasc Surg 63 (Suppl). S3–S21. 2016. View Article : Google Scholar

7 

Pickwell K, Siersma V, Kars M, Apelqvist J, Bakker K, Edmonds M, Holstein P, Jirkovská A, Jude E, Mauricio D, et al: Predictors of lower-extremity amputation in patients with an infected diabetic foot ulcer. Diabetes Care. 38:852–857. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Klenerman L, Mccabe C, Cogley D, Crerand S, Laing P and White M: Screening for patients at risk of diabetic foot ulceration in a general diabetic outpatient clinic. Diabetic Med. 13:561–563. 2015. View Article : Google Scholar

9 

Stappers MH, Hagen F, Reimnitz P, Mouton JW, Meis JF and Gyssens IC: Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections. Eur J Clin Microbiol Infect Dis. 34:1885–1892. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Tennvall GR, Apelqvist J and Eneroth M: Costs of deep foot infections in patients with diabetes mellitus. Pharmacoeconomics. 18:225–238. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Ruan H and Dong LQ: Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol. 8:101–109. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y, He C, Qiu L, Wang Y, Qin X, Liu Y and Li Z: Serum unsaturated free fatty acids: A potential biomarker panel for early-stage detection of colorectal cancer. J Cancer. 7:477–483. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Stern JH, Rutkowski JM and Scherer PE: Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 23:770–784. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Raskin P, Matfin G, Schwartz SL, Chaykin L, Chu PL, Braceras R and Wynne A: Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts). Diabetes Obes Metab. 11:27–32. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Mishra A, Guo Y, Zhang L, More S, Weng T, Chintagari NR, Huang C, Liang Y, Pushparaj S, Gou D, et al: A critical role for P2X7 receptor-induced VCAM-1 shedding and neutrophil infiltration during acute lung injury. J Immunol. 197:2828–2837. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Zhao ZH, Fan YC, Zhao Q, Dou CY, Ji XF, Zhao J, Gao S, Li XY and Wang K: Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure. Clin Epigenetics. 7:1152015. View Article : Google Scholar : PubMed/NCBI

17 

De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, et al: Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth. Oncogene. 34:3493–3503. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Han SS, Kim DK, Kim S, Chin HJ, Chae DW and Na KY: C-reactive protein predicts acute kidney injury and death after coronary artery bypass grafting. Ann Thorac Surg. 104:804–810. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Ghiasi R, Ghadiri Soufi F, Mohaddes G, Alihemmati A, Somi MH, Ebrahimi H, Mirzaie Bavil F and Alipour MR: Influance of regular swimming on serum levels of CRP, IL-6, TNF-α in high-fat diet-induced type 2 diabetic rats. Gen Physiol Biophys. 35:469–476. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Parisi MCR, Moura Neto A, Menezes FH, Gomes MB, Teixeira RM, de Oliveira JEP, Pereira JRD, Fonseca RMC, Guedes LBA, Costa E Forti A, et al: Baseline characteristics and risk factors for ulcer, amputation and severe neuropathy in diabetic foot at risk: The BRAZUPA study. Diabetol Metab Syndr. 8:252016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun H, Zhang X, Shi W and Fang B: Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors. Exp Ther Med 17: 2535-2540, 2019.
APA
Sun, H., Zhang, X., Shi, W., & Fang, B. (2019). Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors. Experimental and Therapeutic Medicine, 17, 2535-2540. https://doi.org/10.3892/etm.2019.7232
MLA
Sun, H., Zhang, X., Shi, W., Fang, B."Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors". Experimental and Therapeutic Medicine 17.4 (2019): 2535-2540.
Chicago
Sun, H., Zhang, X., Shi, W., Fang, B."Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2535-2540. https://doi.org/10.3892/etm.2019.7232
Copy and paste a formatted citation
x
Spandidos Publications style
Sun H, Zhang X, Shi W and Fang B: Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors. Exp Ther Med 17: 2535-2540, 2019.
APA
Sun, H., Zhang, X., Shi, W., & Fang, B. (2019). Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors. Experimental and Therapeutic Medicine, 17, 2535-2540. https://doi.org/10.3892/etm.2019.7232
MLA
Sun, H., Zhang, X., Shi, W., Fang, B."Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors". Experimental and Therapeutic Medicine 17.4 (2019): 2535-2540.
Chicago
Sun, H., Zhang, X., Shi, W., Fang, B."Association of soft tissue infection in the extremity with glucose and lipid metabolism and inflammatory factors". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2535-2540. https://doi.org/10.3892/etm.2019.7232
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