|
1
|
Greulich F, Rudat C and Kispert A:
Mechanisms of T-box gene function in the developing heart.
Cardiovasc Res. 91:212–222. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Cai CL, Martin JC, Sun Y, Cui L, Wang L,
Ouyang K, Yang L, Bu L, Liang X, Zhang X, et al: A myocardial
lineage derives from Tbx18 epicardial cells. Nature. 454:104–108.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wiese C, Grieskamp T, Airik R, Mommersteeg
MT, Gardiwal A, de Gier-de Vries C, Schuster-Gossler K, Moorman AF,
Kispert A and Christoffels VM: Formation of the sinus node head and
differentiation of sinus node myocardium are independently
regulated by Tbx18 and Tbx3. Circ Res. 104:388–397. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Christoffels VM, Grieskamp T, Norden J,
Mommersteeg MT, Rudat C and Kispert A: Tbx18 and the fate of
epicardial progenitors. Nature. 458:E8–E9; discussion E9-E10. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Grieskamp T, Rudat C, Lüdtke TH, Norden J
and Kispert A: Notch signaling regulates smooth muscle
differentiation of epicardium-derived cells. Circ Res. 108:813–823.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Jenkins SJ, Hutson DR and Kubalak SW:
Analysis of the proepicardium-epicardium transition during the
malformation of the RXRalpha-/- epicardium. Dev Dyn. 233:1091–1101.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Witty AD, Mihic A, Tam RY, Fisher SA,
Mikryukov A, Shoichet MS, Li RK, Kattman SJ and Keller G:
Generation of the epicardial lineage from human pluripotent stem
cells. Nat Biotechnol. 32:1026–1035. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tandon P, Miteva YV, Kuchenbrod LM,
Cristea IM and Conlon FL: Tcf21 regulates the specification and
maturation of proepicardial cells. Development. 140:2409–2021.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Jing X, Gao Y, Xiao S, Qin Q, Wei X, Yan
Y, Wu L, Deng S, Du J, Liu Y and She Q: Hypoxia induced the
differentiation of Tbx18-positive epicardial cells to CoSMCs. Sci
Rep. 6:304682016. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
van Wijk B, van den Berg G, Abu-Issa R,
Barnett P, van der Velden S, Schmidt M, Ruijter JM, Kirby ML,
Moorman AF and van den Hoff MJ: Epicardium and myocardium separate
from a common precursor pool by crosstalk between bone
morphogenetic protein- and fibroblast growth factor-signaling
pathways. Circ Res. 105:431–441. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Norden J, Greulich F, Rudat C, Taketo MM
and Kispert A: Wnt/β-catenin signaling maintains the mesenchymal
precursor pool for murine sinus horn formation. Circ Res.
109:e42–e50. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Winnier G, Blessing M, Labosky PA and
Hogan BL: Bone morphogenetic protein-4 is required for mesoderm
formation and patterning in the mouse. Genes Dev. 9:2105–2116.
1995. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Chen JN, van Eeden FJ, Warren KS, Chin A,
Nüsslein-Volhard C, Haffter P and Fishman MC: Left-right pattern of
cardiac BMP4 may drive asymmetry of the heart in zebrafish.
Development. 124:4373–4382. 1997.PubMed/NCBI
|
|
14
|
McCulley DJ, Kang JO, Martin JF and Black
BL: BMP4 is required in the anterior heart field and its
derivatives for endocardial cushion remodeling, outflow tract
septation, and semilunar valve development. Dev Dyn. 237:3200–3209.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Efe JA, Hilcove S, Kim J, Zhou H, Ouyang
K, Wang G, Chen J and Ding S: Conversion of mouse fibroblasts into
cardiomyocytes using a direct reprogramming strategy. Nat Cell
Biol. 13:215–222. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Puskaric S, Schmitteckert S, Mori AD,
Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H and
Rappold G: Shox2 mediates Tbx5 activity by regulating Bmp4 in the
pacemaker region of the developing heart. Hum Mol Genet.
19:4625–4633. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Qin Q, Wang J, Yan Y, Jing X, Du J, Deng
S, Wu L, Liu Y and She Q: Angiotensin II induces the
differentiation of mouse epicardial progenitor cells into vascular
smooth muscle-like cells. Biochem Biophys Res Commun. 480:696–701.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Frank DU, Carter KL, Thomas KR, Burr RM,
Bakker ML, Coetzee WA, Tristani-Firouzi M, Bamshad MJ, Christoffels
VM and Moon AM: Lethal arrhythmias in Tbx3-deficient mice reveal
extreme dosage sensitivity of cardiac conduction system function
and homeostasis. Proc Natl Acad Sci USA. 109:E154–E163. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Hoogaars WM, Tessari A, Moorman AF, de
Boer PA, Hagoort J, Soufan AT, Campione M and Christoffels VM: The
transcriptional repressor Tbx3 delineates the developing central
conduction system of the heart. Cardiovasc Res. 62:489–499. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Bakker ML, Boukens BJ, Mommersteeg MT,
Brons JF, Wakker V, Moorman AF and Christoffels VM: Transcription
factor Tbx3 is required for the specification of the
atrioventricular conduction system. Circ Res. 102:1340–1349. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Boogerd CJ, Wong LY, van den Boogaard M,
Bakker ML, Tessadori F, Bakkers J, 't Hoen PA, Moorman AF,
Christoffels VM and Barnett P: Sox4 mediates Tbx3 transcriptional
regulation of the gap junction protein Cx43. Cell Mol Life Sci.
68:3949–3961. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Hashem SI, Lam ML, Mihardja SS, White SM,
Lee RJ and Claycomb WC: Shox2 regulates the pacemaker gene program
in embryoid bodies. Stem Cells Dev. 22:2915–2926. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Sun C, Yu D, Ye W, Liu C, Gu S, Sinsheimer
NR, Song Z, Li X, Chen C, Song Y, et al: The short stature homeobox
2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal
mesenchymal protrusion development and its temporary function as a
pacemaker during cardiogenesis. J Biol Chem. 290:2007–2023. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nemer G and Nemer M: Transcriptional
activation of BMP-4 and regulation of mammalian organogenesis by
GATA-4 and −6. Dev Biol. 254:131–148. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Espinoza-Lewis RA, Yu L, He F, Liu H, Tang
R, Shi J, Sun X, Martin JF, Wang D, Yang J and Chen Y: Shox2 is
essential for the differentiation of cardiac pacemaker cells by
repressing Nkx2-5. Dev Biol. 327:376–385. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Jay PY, Harris BS, Maguire CT, Buerger A,
Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM,
O'Brien TX, et al: Nkx2-5 mutation causes anatomic hypoplasia of
the cardiac conduction system. J Clin Invest. 113:1130–1137. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Stieber J, Herrmann S, Feil S, Löster J,
Feil R, Biel M, Hofmann F and Ludwig A: The
hyperpolarization-activated channel HCN4 is required for the
generation of pacemaker action potentials in the embryonic heart.
Proc Natl Acad Sci USA. 100:15235–15240. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD,
Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, et
al: BMP type I receptor inhibition reduces heterotopic
ossification. Nat Med. 14:1363–1369. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Katakawa Y, Funaba M and Murakami M:
Smad8/9 is regulated through the BMP pathway. J Cell Biochem.
117:1788–1796. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Miyazono K, Kusanagi K and Inoue H:
Divergence and convergence of TGF-beta/BMP signaling. J Cell
Physiol. 187:265–276. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Verheijck EE, van Kempen MJ, Veereschild
M, Lurvink J, Jongsma HJ and Bouman LN: Electrophysiological
features of the mouse sinoatrial node in relation to connexin
distribution. Cardiovasc Res. 52:40–50. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Christoffels VM, Smits GJ, Kispert A and
Moorman AF: Development of the pacemaker tissues of the heart. Circ
Res. 106:240–254. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Yamamoto M, Dobrzynski H, Tellez J, Niwa
R, Billeter R, Honjo H, Kodama I and Boyett MR: Extended atrial
conduction system characterised by the expression of the HCN4
channel and connexin45. Cardiovasc Res. 72:271–281. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Hoogaars WM, Engel A, Brons JF, Verkerk
AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P,
et al: Tbx3 controls the sinoatrial node gene program and imposes
pacemaker function on the atria. Genes Dev. 21:1098–1112. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Bakker ML, Boink GJ, Boukens BJ, Verkerk
AO, van den Boogaard M, den Haan AD, Hoogaars WM, Buermans HP, de
Bakker JM, Seppen J, et al: T-box transcription factor TBX3
reprogrammes mature cardiac myocytes into pacemaker-like cells.
Cardiovasc Res. 94:439–449. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Ye W, Wang J, Song Y, Yu D, Sun C, Liu C,
Chen F, Zhang Y, Wang F, Harvey RP, et al: A common Shox2-Nkx2-5
antagonistic mechanism primes the pacemaker cell fate in the
pulmonary vein myocardium and sinoatrial node. Development.
142:2521–2532. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Blaschke RJ, Hahurij ND, Kuijper S, Just
S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J,
Hardt SE, et al: Targeted mutation reveals essential functions of
the homeodomain transcription factor Shox2 in sinoatrial and
pacemaking development. Circulation. 115:1830–1838. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Christoffels VM, Mommersteeg MT, Trowe MO,
Prall OW, de Gier-de Vries C, Soufan AT, Bussen M, Schuster-Gossler
K, Harvey RP, Moorman AF and Kispert A: Formation of the venous
pole of the heart from an Nkx2-5-negative precursor population
requires Tbx18. Circ Res. 98:1555–1563. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Espinoza-Lewis RA, Liu H, Sun C, Chen C,
Jiao K and Chen Y: Ectopic expression of Nkx2.5 suppresses the
formation of the sinoatrial node in mice. Dev Biol. 356:359–369.
2011. View Article : Google Scholar : PubMed/NCBI
|
