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Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation

  • Authors:
    • Chengbin Wang
    • Bin Zhu
    • Ming Chen
    • Gaoyan Chen
    • Muzhen Xu
    • Rui Pan
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China
  • Pages: 2715-2719
    |
    Published online on: February 12, 2019
       https://doi.org/10.3892/etm.2019.7257
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Abstract

The objective of this study was to reveal hub pathway cross‑talk for premature newborns with bronchopulmonary dysplasia (BPD) based on the pathway enrichment analysis and Monte Carlo Cross‑Validation (MCCV) method. The inference of key pathway cross‑talk consisted of four parts: i) Identifying differentially expressed genes (DEGs); ii) detecting differentially expressed pathways (DEPs); iii) computing discriminating score (DS) for each pair of DEPs or cross‑talk and investigating seed cross‑talk through the random forest (RF) algorithm and iv) extracting hub cross‑talk dependent on the MCCV method. The results showed that a total of 132 DEGs and 137 DEPs were obtained across BPD patients and normal controls. Using the DS and RF algorithm, 10 seed DEP cross‑talk were detected. By conducting the MCCV on seed cross‑talk, 3 hub cross‑talk for BPD were uncovered: i) The pair of pathways role of interleukin‑17F (IL‑17F) in allergic inflammatory airway diseases and role of IL‑17A in psoriasis; ii) the pair of pathways role of IL random forest 17A in psoriasis and IL‑17A signaling in fibroblasts and ii) the pair of pathways IL‑17A signaling in airway cells and role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza. These 3 hub cross‑talk among DEPs might give an insight to reveal the molecular mechanism underlying the premature newborns with BPD.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Zhu B, Chen M, Chen G, Xu M and Pan R: Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation. Exp Ther Med 17: 2715-2719, 2019.
APA
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., & Pan, R. (2019). Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation. Experimental and Therapeutic Medicine, 17, 2715-2719. https://doi.org/10.3892/etm.2019.7257
MLA
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., Pan, R."Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation". Experimental and Therapeutic Medicine 17.4 (2019): 2715-2719.
Chicago
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., Pan, R."Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2715-2719. https://doi.org/10.3892/etm.2019.7257
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Zhu B, Chen M, Chen G, Xu M and Pan R: Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation. Exp Ther Med 17: 2715-2719, 2019.
APA
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., & Pan, R. (2019). Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation. Experimental and Therapeutic Medicine, 17, 2715-2719. https://doi.org/10.3892/etm.2019.7257
MLA
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., Pan, R."Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation". Experimental and Therapeutic Medicine 17.4 (2019): 2715-2719.
Chicago
Wang, C., Zhu, B., Chen, M., Chen, G., Xu, M., Pan, R."Revealing hub pathway cross-talk for premature newborns with bronchopulmonary dysplasia by the integration of pathway analysis and Monte Carlo Cross-Validation". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2715-2719. https://doi.org/10.3892/etm.2019.7257
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