Impact of hemostatic methods on ovarian reserve and fertility in laparoscopic ovarian cystectomy

Xiao,Jie; Zhou,Jian; Liang,Hui; Liu,Fumin; Xu,Chenchen; Liang,Li

doi:10.3892/etm.2019.7259

April-2019 Volume 17 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April-2019 Volume 17 Issue 4

Full Size Image

Article Open Access

Impact of hemostatic methods on ovarian reserve and fertility in laparoscopic ovarian cystectomy

Authors:
- Jie Xiao
- Jian Zhou
- Hui Liang
- Fumin Liu
- Chenchen Xu
- Li Liang
View Affiliations / Copyright

Affiliations: Department of Gynecology, Xuzhou Maternity and Child Health Care Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China, Cervical Disease Center, Xuzhou Maternity and Child Health Care Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China, Department of Gynaecology and Obstetrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China, B Ultrasonic Room, Xuzhou Maternity and Child Health Care Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China

Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2689-2693
|
Published online on: February 12, 2019

https://doi.org/10.3892/etm.2019.7259
Expand metrics +

Abstract

Impact of hemostatic methods, electrocoagulation versus suture, on ovarian reserve and fertility in laparoscopic ovarian cystectomy was investigated. Eighty patients with bilateral ovarian cysts who underwent laparoscopic ovarian cystectomy were randomly divided into 2 groups based on the hemostatic methods: 40 in suture group and another 40 in electrocoagulation group. Blood samples were drawn from all patients at roughly three time points: Before the surgery, 1 month and 6 months after the surgery. Radioimmunoassay was performed to measure the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-Mullerian hormone (AMH). Moreover, the vaginal ultrasound examination was performed to obtain the ovarian size, peak systolic velocity (PSV) of ovarian stromal blood flow, and antral follicle count (AFC). In terms of postoperative ovarian reserve, the levels of E2 and AMH slightly decreased while the FSH level slightly increased in the suture group at both 1 and 6 months after surgery. In the electrocoagulation group, however, the levels of E2 and AMH decreased significantly while the FSH level increased significantly at 1 month after surgery. Six months after surgery, these levels all returned slightly showing some recovery of ovarian reserve. In comparison between the suture group and the electrocoagulation group, the differences in levels of E2, FSH and AMH were all statistically significant at both 1 and 6 months after surgery (P<0.05). Six months after surgery, the differences in AFC and PSV between the suture group and the electrocoagulation group were statistically significant (P<0.05). In laparoscopic ovarian cystectomy, hemostatic electrocoagulation had a more negative impact on ovarian reserve than hemostatic suture. The use of electrocoagulation for hemostasis should be minimized during the operation, and the suture method should be adopted for hemostasis and shaping of the ovarian wound.

View Figures

View References

1	Peters A, Rindos NB and Lee T: Hemostasis during ovarian cystectomy: Systematic review of the impact of suturing versus surgical energy on ovarian function. J Minim Invasive Gynecol. 24:235–246. 2017. View Article : Google Scholar : PubMed/NCBI
2	Alammari R, Lightfoot M and Hur HC: Impact of cystectomy on ovarian reserve: Review of the literature. J Minim Invasive Gynecol. 24:247–257. 2017. View Article : Google Scholar : PubMed/NCBI
3	Kalme T, Seppälä M, Qiao Q, Koistinen R, Nissinen A, Harrela M, Loukovaara M, Leinonen P and Tuomilehto J: Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. J Clin Endocrinol Metab. 90:1550–1556. 2005. View Article : Google Scholar : PubMed/NCBI
4	Ashrafi M, Madani T, Tehranian AS and Malekzadeh F: Follicle stimulating hormone as a predictor of ovarian response in women undergoing controlled ovarian hyperstimulation for IVF. Int J Gynaecol Obstet. 91:53–57. 2005. View Article : Google Scholar : PubMed/NCBI
5	Wang H, Chen H, Qin Y, Shi Z, Zhao X, Xu J, Ma B and Chen ZJ: Risks associated with premature ovarian failure in Han Chinese women. Reprod Biomed Online. 30:401–407. 2015. View Article : Google Scholar : PubMed/NCBI
6	Pergialiotis V, Prodromidou A, Frountzas M, Bitos K, Perrea D and Doumouchtsis SK: The effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve: A systematic review. Am J Obstet Gynecol. 213:620–628. 2015. View Article : Google Scholar : PubMed/NCBI
7	Morris RT, Gershenson DM, Silva EG, Follen M, Morris M and Wharton JT: Outcome and reproductive function after conservative surgery for borderline ovarian tumors. Obstet Gynecol. 95:541–547. 2000. View Article : Google Scholar : PubMed/NCBI
8	Ding Y, Yuan Y, Ding J, Chen Y, Zhang X and Hua K: Comprehensive assessment of the impact of laparoscopic ovarian cystectomy on ovarian reserve. J Minim Invasive Gynecol. 22:1252–1259. 2015. View Article : Google Scholar : PubMed/NCBI
9	Yoon BS, Kim YS, Seong SJ, Song T, Kim ML, Kim MK and Paek JY: Impact on ovarian reserve after laparoscopic ovarian cystectomy with reduced port number: A randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 176:34–38. 2014. View Article : Google Scholar : PubMed/NCBI
10	Muzii L, Bianchi A and Crocè C: Manci N and Panici PB: Laparoscopic excision of ovarian cysts: is the stripping technique a tissue-sparing procedure? Fertil Steril. 77:609–614. 2002. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Impact of hemostatic methods on ovarian reserve and fertility in laparoscopic ovarian cystectomy

This article is mentioned in:

Abstract

Related Articles