Open Access

MicroRNA‑382 inhibits cancer cell growth and metastasis in NSCLC via targeting LMO3

  • Authors:
    • Dingzhu Chen
    • Yi Zhang
    • Yong Lin
    • Feimin Shen
    • Zhijian Zhang
    • Jiguang Zhou
  • View Affiliations

  • Published online on: February 13, 2019     https://doi.org/10.3892/etm.2019.7271
  • Pages: 2417-2424
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent studies have revealed a pivotal role of microRNAs (miRs) in regulating the initiation and development of multiple types of cancer. In the present study, it was discovered that miR‑382 may be an important tumor suppressor in non‑small cell lung cancer (NSCLC). It was demonstrated that miR‑382 expression was downregulated in tumor tissues from patients with NSCLC compared with adjacent normal tissues. Furthermore, overexpression of miR‑382 suppressed cell proliferation and cell migration of NSCLC cells. In addition, reverse transcription‑quantitative polymerase chain reaction and the luciferase reporter assay revealed that LIM‑only protein 3 (LMO3), an oncogene, acted as a direct target gene of miR‑382. Notably, overexpression of miR‑382 did not alter cell proliferation or migration in LMO3‑silenced A549 cells. Furthermore, analysis of patient tissues indicated an elevation of LMO3 expression in tumor tissues compared with adjacent normal tissues and a negative association between miR‑382 and LMO3 mRNA expression levels. Taken together, the present findings indicated that miR‑382 inhibited NSCLC cell proliferation and metastasis by targeting LMO3, suggesting a tumor suppressor role of miR‑382 in NSCLC.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen D, Zhang Y, Lin Y, Shen F, Zhang Z and Zhou J: MicroRNA‑382 inhibits cancer cell growth and metastasis in NSCLC via targeting LMO3. Exp Ther Med 17: 2417-2424, 2019
APA
Chen, D., Zhang, Y., Lin, Y., Shen, F., Zhang, Z., & Zhou, J. (2019). MicroRNA‑382 inhibits cancer cell growth and metastasis in NSCLC via targeting LMO3. Experimental and Therapeutic Medicine, 17, 2417-2424. https://doi.org/10.3892/etm.2019.7271
MLA
Chen, D., Zhang, Y., Lin, Y., Shen, F., Zhang, Z., Zhou, J."MicroRNA‑382 inhibits cancer cell growth and metastasis in NSCLC via targeting LMO3". Experimental and Therapeutic Medicine 17.4 (2019): 2417-2424.
Chicago
Chen, D., Zhang, Y., Lin, Y., Shen, F., Zhang, Z., Zhou, J."MicroRNA‑382 inhibits cancer cell growth and metastasis in NSCLC via targeting LMO3". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2417-2424. https://doi.org/10.3892/etm.2019.7271