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Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis

  • Authors:
    • Erifili Hatziagelaki
    • Anastasia Tsiavou
    • Charilaos Gerasimou
    • George D. Vavougios
    • Aris Spathis
    • Efstathios Laskos
    • Charalabos Papageorgiou
    • Athanasios Douzenis
    • Nikos Christodoulou
    • Nicolaos Stefanis
    • Demetrios A. Spandidos
    • Nikolaos Nikolakakis
    • Konstantinos Tsamakis
    • Emmanouil Rizos
  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Centre, University General Hospital ‘ATTIKON’, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece, Second Department of Psychiatry, University General Hospital ‘ATTIKON’, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece, Department of Respiratory Medicine, University of Thessaly, School of Medicine, Biopolis, 41100 Larissa, Greece, Department of Biochemistry and Microbiology, Athens Psychiatric Hospital ‘Dromokaition’, 124 61 Athens, Greece, First Department of Psychiatry, Eginition Psychiatric Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28 Athens, Greece, Department of Psychological Medicine, Nottinghamshire Healthcare NHS Trust, University of Nottingham Medical School, Nottingham NG7 2RD, UK, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Hatziagelaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3071-3076
    |
    Published online on: February 18, 2019
       https://doi.org/10.3892/etm.2019.7285
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Abstract

Immunological abnormalities have been implicated in schizophrenia. On the other hand, antipsychotics may exert immunomodulatory effects, by triggering pro‑inflammatory and anti‑inflammatory agents through complex homeostatic mechanisms, which seem to be implicated in medication responsiveness and in the presence or not of adverse effects. There is evidence that olanzapine, a second generation antipsychotic, may increase synapse formation and neurogenesis through alterations in the levels of cytokines and neurotrophic factors. In the present study, we recruited 14 drug‑naive inpatients with first‑episode schizophrenia (male:female ratio, 7:7) with a mean age of 26.5 years. The positive and negative syndrome scale (PANSS) scores and serum levels of a broad spectrum of cytokines and of brain‑derived neurotrophic factor (BDNF) were recorded twice, once at baseline prior to the initiation of olanzapine treatment and 8 weeks later, once the dose of olanzapine had stabilized. Subsequently, the associations between the PANSS scores and the measured markers were examined. Correlation analyses revealed that follow‑up PANSSnegative positively correlated with baseline interleukin (IL)‑6 (ρ=0.685, P=0.007) and baseline IL‑27 levels (ρ=0.785, P=0.001). Furthermore, the percentage change in PANSSnegative [(PANSS‑follow‑up ‑ PANSS‑baseline)/PANSS‑baseline; ΔPANSSnegative%)] positively correlated with baseline IL‑27 (ρ=0.785, P=0.001) and baseline IL‑6 levels (ρ=0.685, P=0.007). Finally, linear regression revealed that follow‑up PANSSnegative was associated with baseline IL‑27 (R2=0.301, P=0.042), ΔPANSSnegative% was associated with baseline IL‑6 (R2=0.301, P=0.042) and baseline IL‑27 levels (R2=0.446, P=0.009). Thus, these findings indicate that IL‑27 and IL‑6 may be trait markers in patients being administered olanzapine monotherapy at the onset of schizophrenia. However, further studies are warranted in order to replicate these associations and to confirm their potential use as biomarkers of treatment effectiveness and safety, as well as to explore novel immunomodulatory strategies for the treatment of schizophrenia.
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View References

1 

van Os J and Kapur S: Schizophrenia. Lancet. 374:635–645. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Jenkins TA: Perinatal complications and schizophrenia: Involvement of the immune system. Front Neurosci. 7:1102013. View Article : Google Scholar : PubMed/NCBI

3 

Benros ME, Nielsen PR, Nordentoft M, Eaton WW, Dalton SO and Mortensen PB: Autoimmune diseases and severe infections as risk factors for schizophrenia: A 30-year population-based register study. Am J Psychiatry. 168:1303–1310. 2011. View Article : Google Scholar : PubMed/NCBI

4 

van Berckel BN, Bossong MG, Boellaard R, Kloet R, Schuitemaker A, Caspers E, Luurtsema G, Windhorst AD, Cahn W, Lammertsma AA, et al: Microglia activation in recent-onset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry. 64:820–822. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Doorduin J, de Vries EF, Willemsen AT, de Groot JC, Dierckx RA and Klein HC: Neuroinflammation in schizophrenia-related psychosis: A PET study. J Nucl Med. 50:1801–1807. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Potvin S, Stip E, Sepehry AA, Gendron A, Bah R and Kouassi E: Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review. Biol Psychiatry. 63:801–808. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Miller BJ, Buckley P, Seabolt W, Mellor A and Kirkpatrick B: Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry. 70:663–671. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, et al: Clinical antipsychotic trials of intervention effectiveness (CATIE) investigators: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 353:1209–1223. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Drzyzga L, Obuchowicz E, Marcinowska A and Herman ZS: Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun. 20:532–545. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Maes M, Bosmans E, Calabrese J, Smith R and Meltzer HY: Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizers. J Psychiatr Res. 29:141–152. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Müller N, Empl M, Riedel M, Schwarz M and Ackenheil M: Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia. Eur Arch Psychiatry Clin Neurosci. 247:308–313. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Meyer U, Schwarz MJ and Müller N: Inflammatory processes in schizophrenia: A promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond. Pharmacol Ther. 132:96–110. 2011. View Article : Google Scholar : PubMed/NCBI

13 

American Psychiatric Association, . Diagnostic and Statistical Manual of Mental Disorders. (4th). American Psychiatric Association. (Washington, DC). 1994.

14 

Kay SR, Fiszbein A and Opler LA: The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13:261–276. 1987. View Article : Google Scholar : PubMed/NCBI

15 

Opler MGA, Yavorsky C and Daniel DG: Positive and Negative Syndrome Scale (PANSS) training: Challenges, solutions, and future directions. Innov Clin Neurosci. 14:77–81. 2017.PubMed/NCBI

16 

Müller N, Riedel M, Ackenheil M and Schwarz MJ: The role of immune function in schizophrenia: An overview. Eur Arch Psychiatry Clin Neurosci. 249 Suppl 4:62–68. 1999. View Article : Google Scholar

17 

Drexhage RC, Hoogenboezem TA, Cohen D, Versnel MA, Nolen WA, van Beveren NJ and Drexhage HA: An activated set point of T-cell and monocyte inflammatory networks in recent-onset schizophrenia patients involves both pro- and anti-inflammatory forces. Int J Neuropsychopharmacol. 14:746–755. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Upthegrove R, Manzanares-Teson N and Barnes NM: Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis. Schizophr Res. 155:101–108. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R and Jones PB: Inflammation and immunity in schizophrenia: Implications for pathophysiology and treatment. Lancet Psychiatry. 2:258–270. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Borovcanin M, Jovanovic I, Radosavljevic G, Djukic Dejanovic S, Stefanovic V, Arsenijevic N and Lukic ML: Antipsychotics can modulate the cytokine profile in schizophrenia: Attenuation of the type-2 inflammatory response. Schizophr Res. 147:103–109. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Gabay C and McInnes IB: The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases. Arthritis Res Ther. 11:2302009. View Article : Google Scholar : PubMed/NCBI

22 

Yoshida H, Nakaya M and Miyazaki Y: Interleukin 27: A double-edged sword for offense and defense. J Leukoc Biol. 86:1295–1303. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Xu M, Mizoguchi I, Morishima N, Chiba Y, Mizuguchi J and Yoshimoto T: Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23 and IL-27. Clin Dev Immunol. 2010:20102010. View Article : Google Scholar

24 

Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, et al: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity. 16:779–790. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Müller N and Schwarz MJ: Immune system and schizophrenia. Curr Immunol Rev. 6:213–220. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hori H, Yoshimura R, Yamada Y, Ikenouchi A, Mitoma M, Ida Y and Nakamura J: Effects of olanzapine on plasma levels of catecholamine metabolites, cytokines, and brain-derived neurotrophic factor in schizophrenic patients. Int Clin Psychopharmacol. 22:21–27. 2007.PubMed/NCBI

27 

Pae CU, Yoon CH, Kim TS, Kim JJ, Park SH, Lee CU, Lee SJ, Lee C and Paik IH: Antipsychotic treatment may alter T-helper (TH)2 arm cytokines. Int Immunopharmacol. 6:666–671. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Zhang XY, Zhou DF, Zhang PY, Wu GY, Cao LY and Shen YC: Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: Association with psychopathology. Schizophr Res. 57:247–258. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM and Yancopoulos GD: NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression. Neuron. 5:501–509. 1990. View Article : Google Scholar : PubMed/NCBI

30 

Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, Shiina A, Hashimoto T, Kanahara N, Hasegawa T, et al: Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS One. 7:e426762012. View Article : Google Scholar : PubMed/NCBI

31 

Rizos EN, Papadopoulou A, Laskos E, Michalopoulou PG, Kastania A, Vasilopoulos D, Katsafouros K and Lykouras L: Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics. World J Biol Psychiatry. 11:251–255. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Rizos EN, Michalopoulou PG, Siafakas N, Stefanis N, Douzenis A, Rontos I, Laskos E, Kastania A, Zoumpourlis V and Lykouras L: Association of serum brain-derived neurotrophic factor and duration of untreated psychosis in first-episode patients with schizophrenia. Neuropsychobiology. 62:87–90. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hatziagelaki E, Tsiavou A, Gerasimou C, Vavougios GD, Spathis A, Laskos E, Papageorgiou C, Douzenis A, Christodoulou N, Stefanis N, Stefanis N, et al: Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis . Exp Ther Med 17: 3071-3076, 2019.
APA
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G.D., Spathis, A., Laskos, E. ... Rizos, E. (2019). Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis . Experimental and Therapeutic Medicine, 17, 3071-3076. https://doi.org/10.3892/etm.2019.7285
MLA
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G. D., Spathis, A., Laskos, E., Papageorgiou, C., Douzenis, A., Christodoulou, N., Stefanis, N., Spandidos, D. A., Nikolakakis, N., Tsamakis, K., Rizos, E."Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis ". Experimental and Therapeutic Medicine 17.4 (2019): 3071-3076.
Chicago
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G. D., Spathis, A., Laskos, E., Papageorgiou, C., Douzenis, A., Christodoulou, N., Stefanis, N., Spandidos, D. A., Nikolakakis, N., Tsamakis, K., Rizos, E."Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis ". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3071-3076. https://doi.org/10.3892/etm.2019.7285
Copy and paste a formatted citation
x
Spandidos Publications style
Hatziagelaki E, Tsiavou A, Gerasimou C, Vavougios GD, Spathis A, Laskos E, Papageorgiou C, Douzenis A, Christodoulou N, Stefanis N, Stefanis N, et al: Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis . Exp Ther Med 17: 3071-3076, 2019.
APA
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G.D., Spathis, A., Laskos, E. ... Rizos, E. (2019). Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis . Experimental and Therapeutic Medicine, 17, 3071-3076. https://doi.org/10.3892/etm.2019.7285
MLA
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G. D., Spathis, A., Laskos, E., Papageorgiou, C., Douzenis, A., Christodoulou, N., Stefanis, N., Spandidos, D. A., Nikolakakis, N., Tsamakis, K., Rizos, E."Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis ". Experimental and Therapeutic Medicine 17.4 (2019): 3071-3076.
Chicago
Hatziagelaki, E., Tsiavou, A., Gerasimou, C., Vavougios, G. D., Spathis, A., Laskos, E., Papageorgiou, C., Douzenis, A., Christodoulou, N., Stefanis, N., Spandidos, D. A., Nikolakakis, N., Tsamakis, K., Rizos, E."Effects of olanzapine on cytokine profile and brain-derived neurotrophic factor in drug-naive subjects with first-episode psychosis ". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3071-3076. https://doi.org/10.3892/etm.2019.7285
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