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Article

Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia

  • Authors:
    • Yu Du
    • Yi Mou
    • Jin Liu
  • View Affiliations / Copyright

    Affiliations: Emergency Department and Intensive Care Unit, West China School of Public Health, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Geroscience and Chronic Disease Department, The 8th Municipal People's Hospital, Chengdu, Sichuan 610083, P.R. China, Department of Anesthesia and Intensive Care, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 3222-3232
    |
    Published online on: February 21, 2019
       https://doi.org/10.3892/etm.2019.7292
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Abstract

Stringent regulations have been established for the intravenous administration of potassium to avoid hyperkalemia in the clinic. The standard approach, however, often does not work well for treating severe hypokalemia. In the present study, a rabbit model of hyperkalemia was used to develop an tailored rapid potassium supplementation strategy and the effectiveness and safety of this new strategy were assessed. A total of 20 rabbits with induced severe hypokalemia were randomly divided into two equal treatment groups. All of the animals were injected with 3% KCl through the auricular marginal veins by a micro‑injection pump; the target serum potassium concentration was 4 mmol/l. The conventional treatment group was administered a continued potassium infusion at the standard infusion rate of 0.4 mmol/kg/h. The tailored rapid supplementation group was treated in two steps: First, a loading dose of potassium was rapidly injected for 5 min and this step was repeated until the serum potassium concentration was increased to 3.5 mmol/l. After this increase in serum potassium concentration, a sustained potassium infusion at a constant dose was performed. Electrocardiogram, blood pressure, respiratory rate, serum potassium concentration, urine volume and vital signs were monitored in real‑time. No hyperkalemia occurred in any of the two the groups. However, compared with the conventional group, the tailored rapid group had a significantly shorter duration of potassium infusion and arrhythmia, and a higher survival rate. In conclusion, these results demonstrate that the tailored rapid potassium supplementation strategy shortened the time of hypokalemia and is a safe and better treatment option to remedy life‑threatening arrhythmia caused by severe hypokalemia with a high success rate.
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1 

Gennari FJ: Hypokalemia. N Engl J Med. 339:451–458. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Welfare W, Sasi P and English M: Challenges in managing profound hypokalaemia. BMJ. 324:269–270. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Bradberry SM and Vale JA: Disturbances of potassium homeostasis in poisoning. J Toxicol Clin Toxicol. 33:295–310. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Yu D, Yi M and Jin L: Incorrigible hypokalemia caused by barium chloride ingestion. Am J Med Sci. 349:279–281. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Schaber DE, Uden DL, Stone FM, Singh A, Katkov H and Bessinger FB: Intravenous KCl supplementation in pediatric cardiac surgical patients. Pediatr Cardiol. 6:25–28. 1985. View Article : Google Scholar : PubMed/NCBI

6 

Prasad A, Ghodsizad A, Pae W, Singbartl K, Boone J, Zeriouh M, Ruhparwar A, Loebe M, Khorrami GS, Koerner MM and Brehm C: Non-cardiac symptoms of moderate to severe hypokalemia in a patient with a syncardia™ total artificial heart. Heart Surg Forum. 19:E12–E13. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Stedwell RE, Allen KM and Binder LS: Hypokalemic paralyses: A review of the etiologies, pathophysiology, presentation, and therapy. Am J Emerg Med. 10:143–148. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Mandal AK: Hypokalemia and hyperkalemia. Med Clin North Am. 81:611–639. 1997. View Article : Google Scholar : PubMed/NCBI

9 

No authors listed, . Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Part 8: advanced challenges in resuscitation: Section 1: Life-threatening electrolyte abnormalities. The American heart association in collaboration with the international liaison committee on resuscitation. Circulation. 102 (Suppl 8):I217–I222. 2000.PubMed/NCBI

10 

Hamill RJ, Robinson LM, Wexler HR and Moote C: Efficacy and safety of potassium infusion therapy in hypokalemic critically ill patients. Crit Care Med. 19:694–699. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Choy AM, Lang CC, Chomsky DM, Rayos GH, Wilson JR and Roden DM: Normalization of acquired QT prolongation in humans by intravenous potassium. Circulation. 96:2149–2154. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Choudhury H and Cary R: Barium and barium compounds. World Health Organisation; Geneva: 2001

13 

Flomenbaum NE: The clinical basis of medical toxicology, section 1, case studies in toxicologic emergencies, pesticides, rodenticides. In: Goldfrank's Toxicologic Emergencies. Goldfrank LR, Flomenbaum NE, Lewin NA, et al: McGraw Hill Medical Publishing Division; pp. 1379–1392. New York, NY: 2002

14 

Tsai CY, Tseng CC, Liu SF, Lin MC and Fang WF: Acute barium intoxication following accidental inhalationof barium chloride. Intern Med J. 41:293–295. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Jourdan S, Bertoni M, Sergio P, Michele P and Rossi M: Suicidal poisoning with barium chloride. Forensic Sci Int. 119:263–265. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Bowen LN, Subramony SH, Cheng J, Wu SS and Okun MS: Elementary, my dear Dr. Allen: The case of barium toxicity and Pa Ping. Neurology. 74:1546–1549. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Rispin A, Farrar D, Margosches E, Gupta K, Stitzel K, Carr G, Greene M, Meyer W and McCall D: Alternative methods for the median lethal dose (LD(50)) test: The up-and-down procedure for acute oral toxicity. ILAR J. 43:233–243. 2002. View Article : Google Scholar : PubMed/NCBI

18 

He Q, Wang JH, Liu YL, Tang PX, Chang ZG, Du LQ and Huang XF: Study on safety and efficacy of concentrated potassium chloride infusions in critically ill patients with hypokalemia. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 20:416–418. 2008.PubMed/NCBI

19 

Rastergar A and Soleimani M: Hypokalaemia and hyperkalaemia. Postgrad Med J. 77:759–764. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Yuming W: Blood circulation. Physiology. Tinghuai W: 4. 9th. People's Health Press; Beijing, BJ: pp. 85–146. 2018

21 

Experimental Animal Anatomy Writing Group of Nankai University, . Anatomy of Experimental Animals. China People's Education Press; pp. 120–121. 1979

22 

Guyton AC, Jones CE and Coleman TG: Normal cardiac output and its variations. Chap 1. Circulatory Physiology: Cardiac Output and its Regulation. WB Sauders; London: pp. 3–20. 1973

23 

Halperin ML and Kamel KS: Potassium. Lancet. 352:135–140. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Thompson CB, Choi C, Youn JH and McDonough AA: Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 276:C1411–C1419. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Muto S: Potassium transport in the mammalian collecting duct. Physiol Rev. 81:85–116. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Bundgaard H and Kjeldsen K: Potassium depletion increases potassium clearance capacity in skeletal muscles in vivo during acute repletion. Am J Physiol Cell Physiol. 283:C1163–C1170. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Lin SH, Cheema-Dhadli S, Gowrishankar M, Marliss EB, Kamel KS and Halperin ML: Control of excretion of potassium: Lessons from studies during prolonged total fasting in human subjects. Am J Physiol. 273:F796–F800. 1997.PubMed/NCBI

28 

Hoskote SS, Joshi SR and Ghosh AK: Disorders of potassium homeostasis: Pathophysiology and management. J Assoc Physicians India. 56:685–693. 2008.PubMed/NCBI

29 

Kruse JA and Carlson RW: Rapid correction of hypokalemia using concentrated intravenous potassium chloride infusions. Arch Intern Med. 150:6131990. View Article : Google Scholar : PubMed/NCBI

30 

Kruse JA, Clark VL, Carlson RW and Geheb MA: Concentrated potassium chloride infusion in critically ill patients with hypokalemia. J ClinPharmacol. 34:1077–1082. 1994.

31 

Coruzzi P, Gualerzi M, Parati G, Brambilla L, Brambilla V, Di Rienzo M and Novarini A: Potassium supplementation improves the natriuretic response to central volume expansion in primary aldosteronism. Metabolism. 52:1597–1600. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Du Y, Mou Y and Liu J: Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia. Exp Ther Med 17: 3222-3232, 2019.
APA
Du, Y., Mou, Y., & Liu, J. (2019). Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia. Experimental and Therapeutic Medicine, 17, 3222-3232. https://doi.org/10.3892/etm.2019.7292
MLA
Du, Y., Mou, Y., Liu, J."Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia". Experimental and Therapeutic Medicine 17.4 (2019): 3222-3232.
Chicago
Du, Y., Mou, Y., Liu, J."Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3222-3232. https://doi.org/10.3892/etm.2019.7292
Copy and paste a formatted citation
x
Spandidos Publications style
Du Y, Mou Y and Liu J: Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia. Exp Ther Med 17: 3222-3232, 2019.
APA
Du, Y., Mou, Y., & Liu, J. (2019). Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia. Experimental and Therapeutic Medicine, 17, 3222-3232. https://doi.org/10.3892/etm.2019.7292
MLA
Du, Y., Mou, Y., Liu, J."Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia". Experimental and Therapeutic Medicine 17.4 (2019): 3222-3232.
Chicago
Du, Y., Mou, Y., Liu, J."Efficiency evaluation and safety monitoring of tailored rapid potassium supplementation strategy for fatal severe hypokalemia". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3222-3232. https://doi.org/10.3892/etm.2019.7292
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