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Article Open Access

Effect of prealbumin level on mortality in heatstroke patients

  • Authors:
    • Qiaoyun Yang
    • Wenming Liu
    • Jianfeng Yu
    • Jianhong Jiang
    • Tongrong Xu
    • Yi Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3053-3060
    |
    Published online on: February 22, 2019
       https://doi.org/10.3892/etm.2019.7298
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Abstract

This study investigated whether serum prealbumin level is associated with mortality in heatstroke patients. A retrospective study of 102 heatstroke patients admitted to the ICU in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from June 2010 to November 2017 was performed they were divided into normal serum prealbumin group (n=79) and low prealbumin group (n=23) according to the difference in PA expression. The clinical data, laboratory inspection data, invasive positive pressure ventilation (IPPV), co-infection, shock and length of ICU stay during the ICU were compared between the two groups of patients. The study endpoints, deaths at admission, were recorded, and the survival curve plotted. Cox regression analysis was performed based on the clinical data of patients, and ROC curve plotted based on Cox multivariate independent prognostic indicators. There were significant differences in clinical variables PLT, ALT, AST, TBIL, ALB, TCH, LDH, TNI, BNP, creatinine, PT, APTT, FBG and D-dimer (P<0.05). The incidence of infection, shock and IPPV was significantly lower in normal serum prealbumin group of patients than those in low prealbumin group (P<0.05). There was a statistically significant difference in short-term survival rate between the groups of patients (χ2=29.101, P<0.001). Prognostic factors for heatstroke patients were IPPV, heart rate, WBC count, PLT count, ALB, PA, TBIL, LDH, CPK, Cr, PCT, PT, APTT, D-dimer, co-infection and shock at admission. Independent prognostic-related factors for heatstroke patients were IPPV, PA level, PLT level, ALB level, CPK level and PT level. When prealbumin <17.95 mg/dl was used as the death threshold for predicting at 28 days, the sensitivity was 77.8%, and the specificity was 85.7%. Significantly associated with the prognosis of heatstroke patients, prealbumin level can be used as an important predictive indicator of the disease progression and worse clinical outcomes.
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1 

Glazer JL: Management of heatstroke and heat exhaustion. Am Fam Physician. 71:2133–2140. 2005.PubMed/NCBI

2 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Hammami MM, Bouchama A, Al-Sedairy S, Shail E, AlOhaly Y and Mohamed GE: Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heatstroke and heatstress. Crit Care Med. 25:1314–1319. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Lee EJ, Lee SW, Park JS, Kim SJ and Hong YS: Successful treatment of severe heat stroke with selective therapeutic hypothermia using an automated surface cooling device. Resuscitation. 84:e77–e78. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Leon LR: Heat stroke and cytokines. Prog Brain Res. 162:481–524. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Vandevyver S, Dejager L, Vandenbroucke RE and Libert C: An acute phase protein ready to go therapeutic for sepsis. EMBO Mol Med. 6:2–3. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Franco J, Formiga F, Trullas JC, Salamanca Bautista P, Conde A, Manzano L, Quirós R, Franco ÁG, Ezquerro AM and Montero-Pérez-Barquero M; RICA investigators group, : Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure. Eur J Intern Med. 43:36–41. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Xie Q, Zhou Y, Xu Z, Yang Y, Kuang D, You H, Ma S, Hao C, Gu Y, Lin S, et al: The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury. BMC Nephrol. 12:302011. View Article : Google Scholar : PubMed/NCBI

9 

Berbel MN, Góes CR, Balbi AL and Ponce D: Nutritional parameters are associated with mortality in acute kidney injury. Clinics (São Paulo). 69:476–482. 2014. View Article : Google Scholar

10 

Lee KH, Cho JH, Kwon O, Kim SU, Kim RH, Cho YW, Jung HY, Choi JY, Kim CD, Kim YL, et al: Low prealbumin levels are independently associated with higher mortality in patients on peritoneal dialysis. Kidney Res Clin Pract. 35:169–175. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Yang HT, Yim H, Cho YS, Kim D, Hur J, Kim JH, Lee BC, Seo DK, Kim HS and Chun W: Prediction of clinical outcomes for massively-burned patients via serum transthyretin levels in the early postburn period. J Trauma Acute Care Surg. 72:999–1005. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Bae HJ, Lee HJ, Han DS, Suh YS, Lee YH, Lee HS, Cho JJ, Kong SH and Yang HK: Prealbumin levels as a useful marker for predicting infectious complications after gastric surgery. J Gastrointest Surg. 15:2136–2144. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Li L, Dai L, Wang X, Wang Y, Zhou L, Chen M and Wang H: Predictive value of the C-reactive protein-to-prealbumin ratio in medical ICU patients. Biomarkers Med. 11:329–337. 2017. View Article : Google Scholar

14 

Hausfater P, Hurtado M, Pease S, Juillien G, Lvovschi VE, Salehabadi S, Lidove O, Wolff M, Bernard M, Chollet-Martin S, et al: Is procalcitonin a marker of critical illness in heatstroke? Intensive Care Med. 34:1377–1383. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Bouchama A, Dehbi M, Mohamed G, Matthies F, Shoukri M and Menne B: Prognostic factors in heat wave related deaths: A meta-analysis. Arch Intern Med. 167:2170–2176. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Davis CJ, Sowa D, Keim KS, Kinnare K and Peterson S: The use of prealbumin and C-reactive protein for monitoring nutrition support in adult patients receiving enteral nutrition in an urban medical center. J Parenter Enteral Nutr. 36:197–204. 2012. View Article : Google Scholar

17 

Prealbumin in Nutritional Care Consensus Group, : Measurement of visceral protein status in assessing protein and energy malnutrition: Standard of care. Nutrition. 11:169–171. 1995.PubMed/NCBI

18 

Wang X, Yuan B, Dong W, Yang B, Yang Y, Lin X and Gong G: Humid heat exposure induced oxidative stress and apoptosis in cardiomyocytes through the angiotensin II signaling pathway. Heart Vessels. 30:396–405. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Quinn CM, Duran RM, Audet GN, Charkoudian N and Leon LR: Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model. J Appl Physiol (1985). 117:971–978. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Hausfater P, Doumenc B, Chopin S, Le Manach Y, Santin A, Dautheville S, Patzak A, Hericord P, Mégarbane B, Andronikof M, et al: Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave. Crit Care. 14:R992010. View Article : Google Scholar : PubMed/NCBI

21 

Ye J, Mo W, Chen Y and Yang A: An analysis of laboratory results of parameters of organ function in patients with heat stroke. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 27:658–661. 2015.(In Chinese). PubMed/NCBI

22 

Jilma B and Derhaschnig U: Disseminated intravascular coagulation in heat stroke: A hot topic. Crit Care Med. 40:1370–1372. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Leon LR and Helwig BG: Heat stroke: Role of the systemic inflammatory response. J Appl Physiol (1985). 109:1980–1988. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Zhao JJ, Zhou JJ, Hu J, Zhou FH, Kang HJ, Liu H, Pan L and Song Q: Analysis of risk factors affecting prognosis of exertional heat stroke. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 25:515–518. 2013.(In Chinese). PubMed/NCBI

25 

Pan ZG, Shao Y, Liu YN, Gu ZT, Zhang XQ, Xu YQ and Su L: Relationship between early coagulability parameters at admission and outcome in patients with severe heatstroke. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 25:725–728. 2013.(In Chinese). PubMed/NCBI

26 

Li Z, Wang Z, Tu X, Lu W, Fang Y, Gao J, Yu S, He R, Shi K and Chu H: Analysis of indicators for clinical prognosis of the patients with heat stroke. Zhonghua Jizhen Yixue Zazhi. 25:1058–1061. 2016.(In Chinese).

27 

Liu Z, Sun X, Tang J, Tang Y, Tong H, Wen Q, Liu Y and Su L: Intestinal inflammation and tissue injury in response to heat stress and cooling treatment in mice. Mol Med Rep. 4:437–443. 2011.PubMed/NCBI

28 

Leon LR, Blaha MD and DuBose DA: Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery. J Appl Physiol (1985). 100:1400–1409. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Lim CL and Mackinnon LT: The roles of exercise-induced immune system disturbances in the pathology of heat stroke: The dual pathway model of heat stroke. Sports Med. 36:39–64. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Hsu CC, Niu CS and Lin MT: Decrease of heatstroke-induced multiorgan dysfunction by whole body cooling in streptozotocin-induced diabetic rats. Chin J Physiol. 52:47–55. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Tong HS, Liu YS, Wen Q, Tang YQ, Yuan FF and Su L: Serum procalcitonin predicting mortality in exertional heatstroke. Emerg Med J. 29:113–117. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, Lowe GD, Pepys MB and Gudnason V: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 350:1387–1397. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Martin C, Boisson C, Haccoun M, Thomachot L and Mege JL: Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med. 25:1813–1819. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Pourakbari B, Mamishi S, Zafari J, Khairkhah H, Ashtiani MH, Abedini M, Afsharpaiman S and Rad SS: Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection. Braz J Infect Dis. 14:252–255. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Yousef AA, Amr YM and Suliman GA: The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: A prospective observational study. Crit Care. 14:R332010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Q, Liu W, Yu J, Jiang J, Xu T and Zhou Y: Effect of prealbumin level on mortality in heatstroke patients. Exp Ther Med 17: 3053-3060, 2019.
APA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., & Zhou, Y. (2019). Effect of prealbumin level on mortality in heatstroke patients. Experimental and Therapeutic Medicine, 17, 3053-3060. https://doi.org/10.3892/etm.2019.7298
MLA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17.4 (2019): 3053-3060.
Chicago
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3053-3060. https://doi.org/10.3892/etm.2019.7298
Copy and paste a formatted citation
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Spandidos Publications style
Yang Q, Liu W, Yu J, Jiang J, Xu T and Zhou Y: Effect of prealbumin level on mortality in heatstroke patients. Exp Ther Med 17: 3053-3060, 2019.
APA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., & Zhou, Y. (2019). Effect of prealbumin level on mortality in heatstroke patients. Experimental and Therapeutic Medicine, 17, 3053-3060. https://doi.org/10.3892/etm.2019.7298
MLA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17.4 (2019): 3053-3060.
Chicago
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3053-3060. https://doi.org/10.3892/etm.2019.7298
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