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Effect of prealbumin level on mortality in heatstroke patients

  • Authors:
    • Qiaoyun Yang
    • Wenming Liu
    • Jianfeng Yu
    • Jianhong Jiang
    • Tongrong Xu
    • Yi Zhou

  • View Affiliations

  • Published online on: February 22, 2019     https://doi.org/10.3892/etm.2019.7298
  • Pages: 3053-3060

  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated whether serum prealbumin level is associated with mortality in heatstroke patients. A retrospective study of 102 heatstroke patients admitted to the ICU in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from June 2010 to November 2017 was performed they were divided into normal serum prealbumin group (n=79) and low prealbumin group (n=23) according to the difference in PA expression. The clinical data, laboratory inspection data, invasive positive pressure ventilation (IPPV), co-infection, shock and length of ICU stay during the ICU were compared between the two groups of patients. The study endpoints, deaths at admission, were recorded, and the survival curve plotted. Cox regression analysis was performed based on the clinical data of patients, and ROC curve plotted based on Cox multivariate independent prognostic indicators. There were significant differences in clinical variables PLT, ALT, AST, TBIL, ALB, TCH, LDH, TNI, BNP, creatinine, PT, APTT, FBG and D-dimer (P<0.05). The incidence of infection, shock and IPPV was significantly lower in normal serum prealbumin group of patients than those in low prealbumin group (P<0.05). There was a statistically significant difference in short-term survival rate between the groups of patients (χ2=29.101, P<0.001). Prognostic factors for heatstroke patients were IPPV, heart rate, WBC count, PLT count, ALB, PA, TBIL, LDH, CPK, Cr, PCT, PT, APTT, D-dimer, co-infection and shock at admission. Independent prognostic-related factors for heatstroke patients were IPPV, PA level, PLT level, ALB level, CPK level and PT level. When prealbumin <17.95 mg/dl was used as the death threshold for predicting at 28 days, the sensitivity was 77.8%, and the specificity was 85.7%. Significantly associated with the prognosis of heatstroke patients, prealbumin level can be used as an important predictive indicator of the disease progression and worse clinical outcomes.
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April-2019
Volume 17 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang Q, Liu W, Yu J, Jiang J, Xu T and Zhou Y: Effect of prealbumin level on mortality in heatstroke patients. Exp Ther Med 17: 3053-3060, 2019
APA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., & Zhou, Y. (2019). Effect of prealbumin level on mortality in heatstroke patients. Experimental and Therapeutic Medicine, 17, 3053-3060. https://doi.org/10.3892/etm.2019.7298
MLA
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17.4 (2019): 3053-3060.
Chicago
Yang, Q., Liu, W., Yu, J., Jiang, J., Xu, T., Zhou, Y."Effect of prealbumin level on mortality in heatstroke patients". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3053-3060. https://doi.org/10.3892/etm.2019.7298