Value of MRI enhanced FLAIR sequence examination combined with CSF TNF‑α detection in the early diagnosis of neonatal purulent meningitis

Zhang,Yanli; Sun,Xiaolin; Wu,Jun; Sun,Airong

doi:10.3892/etm.2019.7305

April-2019 Volume 17 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April-2019 Volume 17 Issue 4

Full Size Image

Article Open Access

Value of MRI enhanced FLAIR sequence examination combined with CSF TNF‑α detection in the early diagnosis of neonatal purulent meningitis

Authors:
- Yanli Zhang
- Xiaolin Sun
- Jun Wu
- Airong Sun
View Affiliations / Copyright

Affiliations: Department of Pediatrics, Linyi Women and Children's Hospital, Linyi, Shandong 276014, P.R. China, Department of Neonatology, Linyi Women and Children's Hospital, Linyi, Shandong 276014, P.R. China, Department of Radiology, Linyi Women and Children's Hospital, Linyi, Shandong 276014, P.R. China
Pages: 3124-3128
|
Published online on: February 22, 2019

https://doi.org/10.3892/etm.2019.7305
Expand metrics +

Abstract

This study aimed to investigate the value of MRI enhanced fluid‑attenuated inversion recovery (FLAIR) combined with TNF‑α in cerebrospinal fluid in the diagnosis of neonatal purulent meningitis. Fifty neonates with purulent meningitis were randomly selected in the purulency group, 50 patients with viral meningitis (VM) in the virus group and 50 neonates without purulent meningitis in the no meningitis group. All neonates were selected from April 2015 to May 2018 in Women and Children's Hospital (Linyi, China). Clinical baseline data of the three groups were compared, and logistic regression analysis was conducted to analyze the risk factors of the disease. The risk factors of neonatal purulent meningitis include white bold cell count, TNF‑α, encephaledema, encephaledema combined with abnormal EEG, erythrocyte sedimentation rate and FLAIR sequential apparent diffusion coefficient (ADC). TNF‑α in cerebrospinal fluid combined with FLAIR sequential ADC obtained higher sensitivity, specificity, positive predictive value, negative predictive value, diagnostic accuracy and AUC than single TNF‑α in cerebrospinal fluid examination or single FLAIR sequence. MRI enhanced FLAIR sequence scan combined with TNF‑α in cerebrospinal fluid has the highest rate in early diagnosis of neonatal purulent meningitis, and it is worthy of clinical promotion.

View Figures

View References

1	The Collaborative Group For Neonatal Meningitis Study TC, ; Liu CQ: Epidemiology of neonatal purulent meningitis in Hebei Province, China: A multicenter study. Zhongguo Dang Dai Er Ke Za Zhi. 17:419–424. 2015.(In Chinese). PubMed/NCBI
2	Prasad R, Kapoor R, Srivastava R, Mishra OP and Singh TB: Cerebrospinal fluid TNF-α, IL-6, and IL-8 in children with bacterial meningitis. Pediatr Neurol. 50:60–65. 2014. View Article : Google Scholar : PubMed/NCBI
3	Jeevanandham B, Kalyanpur T, Gupta P and Cherian M: Comparison of post-contrast 3D-T1-MPRAGE, 3D-T1-SPACE and 3D-T2-FLAIR MR images in evaluation of meningeal abnormalities at 3-T MRI. Br J Radiol. 90:201608342017. View Article : Google Scholar : PubMed/NCBI
4	Pfausler B, Grubwieser G, Bösch S, Vollert H, Herald M and Schmutzhard E: Cerebrospinal fluid-filtration reduces TNF alpha in bacterial meningitis-CSF. Eur J Neurol. 2:570–572. 1995. View Article : Google Scholar : PubMed/NCBI
5	Abe M, Takayama Y, Yamashita H, Noguchi M and Sagoh T: Purulent meningitis with unusual diffusion-weighted MRI findings. Eur J Radiol. 44:1–4. 2002. View Article : Google Scholar : PubMed/NCBI
6	Sohn CH, Sevick RJ, Frayne R, Chang HW, Kim SP and Kim DK: Fluid attenuated inversion recovery (FLAIR) imaging of the normal brain: Comparisons between under the conditions of 3.0 Tesla and 1.5 Tesla. Korean J Radiol. 11:19–24. 2010. View Article : Google Scholar : PubMed/NCBI
7	Nigrovic LE, Fine AM, Monuteaux MC, Shah SS and Neuman MI: Trends in the management of viral meningitis at United States children's hospitals. Pediatrics. 131:670–676. 2013. View Article : Google Scholar : PubMed/NCBI
8	Bociąga-Jasik M, Garlicki A, Cieśla A, Kalinowska-Nowak A, Sobczyk-Krupiarz I and Mach T: The diagnostic value of cytokine and nitric oxide concentrations in cerebrospinal fluid for the differential diagnosis of meningitis. Adv Med Sci. 57:142–147. 2012. View Article : Google Scholar : PubMed/NCBI
9	Panato AP, Tomasi LT, Simon CS, Madeira K, Simoes LR, Medeiros LR, Barichello T and Rosa MI: Meta-analysis identifies tumor necrosis factor-alpha and interleukin-1 beta as diagnostic biomarkers for bacterial and aseptic meningitis. Curr Neurovasc Res. 11:340–348. 2014. View Article : Google Scholar : PubMed/NCBI
10	Splendiani A, Puglielli E, De Amicis R, Necozione S, Masciocchi C and Gallucci M: Contrast-enhanced FLAIR in the early diagnosis of infectious meningitis. Neuroradiology. 47:591–598. 2005. View Article : Google Scholar : PubMed/NCBI
11	Letiembre M, Echchannaoui H, Ferracin F, Rivest S and Landmann R: Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol. 168:21–33. 2005. View Article : Google Scholar : PubMed/NCBI
12	Kim HJ, Shim KW, Lee MK, Park MS, Kim SH, Kim EY, Park S and Kim TS: Tuberculous encephalopathy without meningitis: Pathology and brain MRI findings. Eur Neurol. 65:156–159. 2011. View Article : Google Scholar : PubMed/NCBI
13	Šumanović-Glamuzina D, Čulo F, Čulo MI, Konjevoda P and Jerković-Raguž M: A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia. Bosn J Basic Med Sci. 17:203–210. 2017.PubMed/NCBI
14	Vaswani AK, Nizamani WM, Ali M, Aneel G, Shahani BK and Hussain S: Diagnostic accuracy of contrast-enhanced FLAIR magnetic resonance imaging in diagnosis of meningitis correlated with CSF analysis. ISRN Radiol. 2014:5789862014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Value of MRI enhanced FLAIR sequence examination combined with CSF TNF‑α detection in the early diagnosis of neonatal purulent meningitis

This article is mentioned in:

Abstract

Figure 1

Related Articles