Development of a poly‑L‑lactide salivary duct stent

Ding,Yi‑Fang; Tseng,How; Su,Chin‑Hui; Tai,Chien‑Cheng; Wu,Yuan‑Yi; Haung,Cheng‑Ji; Lee,Cheng‑Shen; Hung,Shih‑Han

doi:10.3892/etm.2019.7308

April-2019 Volume 17 Issue 4

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April-2019 Volume 17 Issue 4

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Article Open Access

Development of a poly‑L‑lactide salivary duct stent

Authors:
- Yi‑Fang Ding
- How Tseng
- Chin‑Hui Su
- Chien‑Cheng Tai
- Yuan‑Yi Wu
- Cheng‑Ji Haung
- Cheng‑Shen Lee
- Shih‑Han Hung
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Affiliations: Department of Otolaryngology, Taipei Medical University Wan‑Fang Hospital, Taipei 110, Taiwan, R.O.C., Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, R.O.C., Department of Otolaryngology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, R.O.C.

Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2907-2912
|
Published online on: February 25, 2019

https://doi.org/10.3892/etm.2019.7308
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Abstract

Obstructive salivary gland diseases are common conditions that arise following the disruption of the secretary ductal system and usually results in the swelling and pain of the affected gland(s). There has been an increase in the use of sialendoscopy for the treatment and diagnosis of obstructive salivary gland infection. If damage occurs to a duct or papilla following sialendoscopy, a stent may be necessary to prevent restenosis and for maintaining the salivary duct open after complete sialendoscopy. Currently, there are only non‑biodegradable salivary duct stents available. The aim of the current study was to establish a methodology for the fabrication of a biodegradable poly‑L‑lactide (PLLA) salivary duct stent and to examine its function in an animal model. In the current study, PLLA was used to fabricate a salivary duct stent, which was compared with other commercially available non‑biodegradable products. The mechanical tests revealed that the tensile strength of the PLLA stent was similar to that of the commercially available non‑biodegradable stents. The Young's modulus, which measures the stiffness of a solid material, was significantly higher for the PLLA stent compared with the commercially available non‑biodegradable stents. In addition, the current study demonstrated that the PLLA salivary duct stent was easily used with current sialendoscopy techniques, allowing accurate stent placement in an animal model.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Development of a poly‑L‑lactide salivary duct stent

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