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Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes

  • Authors:
    • Liping Wang
    • Zhankai Lu
    • Xuewu Zhou
    • Yong Ding
    • Lijie Guan
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, P.R. China, Department of Paediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, P.R. China
  • Pages: 2979-2984
    |
    Published online on: February 26, 2019
       https://doi.org/10.3892/etm.2019.7312
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Abstract

The effects of intrahepatic cholestasis of pregnancy (ICP) on hepatic function, changes of inflammatory cytokines and fetal outcomes were studied. In total, 663 pregnant women admitted to Daqing Longnan Hospital from July 2016 to December 2017 were selected. There were, 40 cases with ICP enrolled in the observation group, and 40 normal pregnant women were recruited in the normal group. They were also grouped according to hepatic function and inflammatory cytokines, with 40 cases in each group. Neonatal Apgar scores were recorded. The correlations of serum cholylglycine (CG) in pregnant women with umbilical artery systolic-to-diastolic (S/D) ratio in the third trimester of pregnancy, the alanine aminotransferase level, the high‑sensitivity C-reactive protein (hs-CRP) level, neonatal Apgar score and gestational week were analyzed. The birth weight in the observation group was lighter than that in the normal group (P<0.05); the gestational week at birth was earlier than that in the normal group (P<0.05); Apgar score at birth was lower than that in the normal group (P<0.05), and the levels of inflammatory cytokines were higher than those in the control group (P<0.05). Apgar scores of newborns at birth and at 1 and 5 min after birth in the normal hepatic function and normal inflammatory cytokine groups were higher than those in the abnormal hepatic function group (P<0.05). The serum CG level in pregnant women was positively correlated with umbilical artery S/D ratio, the alanine aminotransferase level and the hs-CRP level in the third trimester of pregnancy, but negatively correlated with neonatal Apgar score and gestational week. Among patients with ICP, the higher the GG level in the body is, the higher the alanine aminotransferase, inflammatory cytokine and umbilical artery S/D ratio will be, which may cause lower neonatal Apgar score, neonatal asphyxia and premature delivery.
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1 

Estiú MC, Frailuna MA, Otero C, Dericco M, Williamson C, Marin JJG and Macias RIR: Relationship between early onset severe intrahepatic cholestasis of pregnancy and higher risk of meconium-stained fluid. PLoS One. 12:e01765042017. View Article : Google Scholar : PubMed/NCBI

2 

Günaydin B, Bayram M, Altuğ M, Cevher S and Bozkurt N: Retrospective analysis of maternal, fetal, and neonatal outcomesof intrahepatic cholestasis of pregnancy at Gazi University. Turk J Med Sci. 47:583–586. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Kong X, Kong Y, Zhang F, Wang T and Zhu X: Expression and significance of dendritic cells and Th17/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 31:901–906. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Tayyar AT, Kozalı S, Yetkin Yildirim G, Karakus R, Yuksel IT, Erel O, Neselioglu S and Eroglu M: Role of ischemia-modified albumin in the evaluation of oxidative stress in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 11:1–5. 2018. View Article : Google Scholar

5 

Sharifzadehgan S, Hermann M, Nedellec S, De Luca D and Benachi A: Intrahepatic cholestasis of pregnancy: Shorter duration of labor? Eur J Obstet Gynecol Reprod Biol. 225:258–259. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Feng C, Li WJ, He RH, Sun XW, Wang G and Wang LQ: Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies. Sci Rep. 8:39852018. View Article : Google Scholar : PubMed/NCBI

7 

Wood AM, Livingston EG, Hughes BL and Kuller JA: Intrahepatic cholestasis of pregnancy: A review of diagnosis and management. Obstet Gynecol Surv. 73:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Covach AJ and Rose WN: Intrahepatic cholestasis of pregnancy refractory to multiple medical therapies and plasmapheresis. AJP Rep. 7:e223–e225. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Floreani A and Gervasi MT: New insights on intrahepatic cholestasis of pregnancy. Clin Liver Dis. 20:177–189. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Koroglu N, Tayyar A, Tola EN, Yetkin Yildirim G, Temel Yuksel I, Aslan Cetin B, Dag I and Acar DK: Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 12:1–6. 2017.

11 

Lin J, Gu W and Hou Y: Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: a prospective study. J Matern Fetal Neonatal Med. 7:1–7. 2017.

12 

Mei Y, Gao L, Lin Y, Luo D, Zhou X and He L: Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy with dichorionic diamniotic twin pregnancies. J Matern Fetal Neonatal Med. 32:472–476. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Adeyemi O, Alvarez-Laviada A, Schultz F, Ibrahim E, Trauner M, Williamson C, Glukhov AV and Gorelik J: Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis. PLoS One. 12:e01831672017. View Article : Google Scholar : PubMed/NCBI

14 

Li L, Chen YH, Yang YY and Cong L: Effect of intrahepatic cholestasis of pregnancy on neonatal birth weight: A meta-analysis. J Clin Res Pediatr Endocrinol. 10:38–43. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Dadhwal V, Sharma A, Khoiwal K, Deka D, Sarkar P and Vanamail P: Pregnancy outcomes in HIV-infected women: Experience from a tertiary care center in India. Int J MCH AIDS. 6:75–81. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Maldonado M, Alhousseini A, Awadalla M, Idler J, Welch R, Puder K, Patwardhan M and Gonik B: Intrahepatic cholestasis of pregnancy leading to severe vitamin K deficiency and coagulopathy. Case Rep Obstet Gynecol. 2017:56462472017.PubMed/NCBI

17 

Herrera CA, Manuck TA, Stoddard GJ, Varner MW, Esplin S, Clark EAS, Silver RM and Eller AG: Perinatal outcomes associated with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 31:1913–1920. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Mattila M, Kemppainen H, Isoniemi H and Polo-Kantola P: Pregnancy outcomes after liver transplantation in Finland. Acta Obstet Gynecol Scand. 96:1106–1111. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Tayyar A, Temel Yuksel I, Koroglu N, Tanay Tayyar A, Alici Davutoglu E, Akkaya Firat A and Aslan Cetin B: Maternal copeptin levels in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med. 31:2066–2070. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Sanhal CY, Daglar K, Kara O, Yılmaz ZV, Turkmen GG, Erel O, Uygur D and Yucel A: An alternative method for measuring oxidative stress in intrahepatic cholestasis of pregnancy: Thiol/disulphide homeostasis. J Matern Fetal Neonatal Med. 31:1477–1482. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Türkmen GG, Timur H, Yilmaz Z, Kirbas A, Daglar K, Tokmak A, Uygur D and Danişman N: Effect of intrahepatic cholestasis of pregnancy on maternal serum screening tests. J Neonatal Perinatal Med. 9:411–415. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Lu Z, Zhou X, Ding Y and Guan L: Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. Exp Ther Med 17: 2979-2984, 2019.
APA
Wang, L., Lu, Z., Zhou, X., Ding, Y., & Guan, L. (2019). Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. Experimental and Therapeutic Medicine, 17, 2979-2984. https://doi.org/10.3892/etm.2019.7312
MLA
Wang, L., Lu, Z., Zhou, X., Ding, Y., Guan, L."Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes". Experimental and Therapeutic Medicine 17.4 (2019): 2979-2984.
Chicago
Wang, L., Lu, Z., Zhou, X., Ding, Y., Guan, L."Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2979-2984. https://doi.org/10.3892/etm.2019.7312
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Lu Z, Zhou X, Ding Y and Guan L: Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. Exp Ther Med 17: 2979-2984, 2019.
APA
Wang, L., Lu, Z., Zhou, X., Ding, Y., & Guan, L. (2019). Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes. Experimental and Therapeutic Medicine, 17, 2979-2984. https://doi.org/10.3892/etm.2019.7312
MLA
Wang, L., Lu, Z., Zhou, X., Ding, Y., Guan, L."Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes". Experimental and Therapeutic Medicine 17.4 (2019): 2979-2984.
Chicago
Wang, L., Lu, Z., Zhou, X., Ding, Y., Guan, L."Effects of intrahepatic cholestasis of pregnancy on hepatic function, changes of inflammatory cytokines and fetal outcomes". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2979-2984. https://doi.org/10.3892/etm.2019.7312
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