Identification of lncRNA competitively regulated subpathways in myocardial infarction Corrigendum in /10.3892/etm.2019.8210

Wu,Xia; Sun,Lili; Wang,Ziliang

doi:10.3892/etm.2019.7320

Identification of lncRNA competitively regulated subpathways in myocardial infarction

Corrigendum in: /10.3892/etm.2019.8210

Authors:
- Xia Wu
- Lili Sun
- Ziliang Wang
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Affiliations: Department of Geriatrics, Daqing Oilfield General Hospital, Daqing, Heilongjiang 163316, P.R. China, Department of Cardiovascular Medicine, Daqing People's Hospital, Daqing, Heilongjiang 163316, P.R. China
Published online on: February 26, 2019 https://doi.org/10.3892/etm.2019.7320
Pages: 3041-3046
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The functions of long non-coding RNAs (lncRNAs) in myocardial infarction (MI) remain largely unknown. Thus, we used the subp athway-LINCE method to characterize the potential roles of lncRNAs in MI. Candidate lncRNA-mRNA interactions were obtained from miRNA-mRNA interactions and lncRNA-miRNA interactions. Then the lncRNA and mRNA co-expression relationship pairs (LncGenePairs) were screened from the lncRNAs and mRNA intersections, which were extracted through candidate lncRNA-mRNA interactions and sample gene expression profiles. The lncRNAs in LncGenePairs were embedded into pathway graphs as nodes through linking to their regulated mRNAs, which resulted in obtaining condition-specific lncRNA competitively regulated signal pathways (csLncRPs). Finally, the csLncRPs were calculated using lenient distance similarity to obtain the lncRNA competitively regulated subpathways. Based on the statistical significance of signal subpathways, lncRNA-mRNA networks were constructed, in which hub lncRNAs were selected. A total of 65 lncRNAs competitively regulated subpathways and 13 hub lncRNAs were obtained, which associated with a risk of MI. Identifying lncRNAs competitively regulated subpathways not only provides potential lncRNA biomarkers for MI, but also helps the understanding of pathogenesis of MI.

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