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Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis

  • Authors:
    • Bing-Gang Guan
    • Xiao-Xi Cai
  • View Affiliations / Copyright

    Affiliations: Spine Surgery, Tianjin Hospital, Tianjin 300211, P.R. China, Department of Orthopedics, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2894-2900
    |
    Published online on: February 27, 2019
       https://doi.org/10.3892/etm.2019.7326
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Abstract

Abnormal sub-pathways competitively regulated by long non-coding RNAs (lncRNAs) for postmenopausal osteoporosis (PO) based on integration of lncRNA-mRNA expression data and pathway network topologies were inve-stigated. Interesting lncRNA-mRNA pairs were selected by Pearson's correlation coefficient (PCC) algorithm on the basis of lncRNA-miRNA and miRNA-mRNA interactions and gene expression profiles. Then, lncRNAs in interesting pairs were embedded into pathway graphs as signature nodes by linking to their regulated-mRNAs, and lncRNA competitively regulated pathways (LCRPs) were gained for PO patients. Moreover, sub-pathways were detected dependent on the shortest distance similarity and the pathway topology. The abnormal sub-pathways were determined utilizing the Wallenius approximation methods through evaluating the statistical significance of sub-pathways. In total 75 interesting lncRNA-mRNA pairs (representing 17 lncRNAs and 74 mRNAs) were identified. Subsequently, 42 LCRPs were extracted from pathway graphs by signature lncRNA regulated mRNAs. Moreover, 14 abnormal sub-pathways with P<0.05 were obtained between PO patients and controls, such as sub-pathways of PI3K-Akt signaling pathway and long-term potentiation. This finding may facilitate understanding the molecular mechanism of PO, and point a new direction to identify potential biomarkers for treatment and prevention of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Guan B and Cai X: Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis. Exp Ther Med 17: 2894-2900, 2019.
APA
Guan, B., & Cai, X. (2019). Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis. Experimental and Therapeutic Medicine, 17, 2894-2900. https://doi.org/10.3892/etm.2019.7326
MLA
Guan, B., Cai, X."Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis". Experimental and Therapeutic Medicine 17.4 (2019): 2894-2900.
Chicago
Guan, B., Cai, X."Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2894-2900. https://doi.org/10.3892/etm.2019.7326
Copy and paste a formatted citation
x
Spandidos Publications style
Guan B and Cai X: Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis. Exp Ther Med 17: 2894-2900, 2019.
APA
Guan, B., & Cai, X. (2019). Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis. Experimental and Therapeutic Medicine, 17, 2894-2900. https://doi.org/10.3892/etm.2019.7326
MLA
Guan, B., Cai, X."Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis". Experimental and Therapeutic Medicine 17.4 (2019): 2894-2900.
Chicago
Guan, B., Cai, X."Abnormal sub-pathways competitively regulated by lncRNAs contribute to postmenopausal osteoporosis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2894-2900. https://doi.org/10.3892/etm.2019.7326
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