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Article

Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis

  • Authors:
    • Jian Lu
    • Hong‑Wei Zhao
    • Yu Chen
    • Jin‑Huan Wei
    • Zhen‑Hua Chen
    • Zi‑Hao Feng
    • Yong Huang
    • Wei Chen
    • Jun‑Hang Luo
    • Yong Fang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Jiangmen Hospital, Sun Yat‑Sen University, Jiangmen, Guangdong 529030, P.R. China, Department of Urology, Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Jinan, Shandong 264000, P.R. China, Department of Urology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 3741-3747
    |
    Published online on: March 1, 2019
       https://doi.org/10.3892/etm.2019.7331
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Abstract

Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate the expression of EIF5A2 in prostate cancer (PCa) and its association with biological and prognostic significance. EIF5A2 mRNA and protein levels were analyzed in three paired samples of freshly resected PCa and adjacent non‑tumor tissues. Immunohistochemical staining was used to detect the expression of EIF5A2 protein levels in 72 paraffin‑embedded PCa tumor specimens. Subsequently, the association between EIF5A2 protein expression and clinicopathological parameters was assessed. Semi‑quantitative reverse transcription‑polymerase chain reaction and western blot analyses showed both EIF5A2 mRNA and protein levels were elevated in PCa compared with adjacent non‑tumor tissues. Elevated EIF5A2 protein levels were observed in 73.6% (53/72) of the clinical PCa tissues using immunohistochemical staining. EIF5A2 expression was significantly associated with tumor stage (P=0.011) and biochemical recurrence status (P=0.032). Additionally, high levels of EIF5A2 predicted worse progression‑free survival (P=0.007). Multivariate Cox regression analysis indicated that high expression of EIF5A2 was an independent prognostic factor for poor progression‑free survival (hazard ratios, 0.366; 95% confidence interval, 0.349‑0.460; P=0.021). The present study demonstrated that EIF5A2 is overexpressed in prostate cancer and may be a potential predictor and therapeutic target in PCa patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lu J, Zhao HW, Chen Y, Wei JH, Chen ZH, Feng ZH, Huang Y, Chen W, Luo JH, Fang Y, Fang Y, et al: Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis. Exp Ther Med 17: 3741-3747, 2019.
APA
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z. ... Fang, Y. (2019). Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis. Experimental and Therapeutic Medicine, 17, 3741-3747. https://doi.org/10.3892/etm.2019.7331
MLA
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z., Huang, Y., Chen, W., Luo, J., Fang, Y."Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis". Experimental and Therapeutic Medicine 17.5 (2019): 3741-3747.
Chicago
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z., Huang, Y., Chen, W., Luo, J., Fang, Y."Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3741-3747. https://doi.org/10.3892/etm.2019.7331
Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Zhao HW, Chen Y, Wei JH, Chen ZH, Feng ZH, Huang Y, Chen W, Luo JH, Fang Y, Fang Y, et al: Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis. Exp Ther Med 17: 3741-3747, 2019.
APA
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z. ... Fang, Y. (2019). Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis. Experimental and Therapeutic Medicine, 17, 3741-3747. https://doi.org/10.3892/etm.2019.7331
MLA
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z., Huang, Y., Chen, W., Luo, J., Fang, Y."Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis". Experimental and Therapeutic Medicine 17.5 (2019): 3741-3747.
Chicago
Lu, J., Zhao, H., Chen, Y., Wei, J., Chen, Z., Feng, Z., Huang, Y., Chen, W., Luo, J., Fang, Y."Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3741-3747. https://doi.org/10.3892/etm.2019.7331
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