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Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography

  • Authors:
    • Baohua Wang
    • Tian'an Jiang
    • Min Huang
    • Jing Wang
    • Yanhua Chu
    • Liyun Zhong
    • Shusen Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3655-3663
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    Published online on: March 6, 2019
       https://doi.org/10.3892/etm.2019.7353
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Abstract

The purpose of the present study was to investigate whether contrast‑enhanced ultrasonography (CEUS) in combination with ultrasound elastography (UE) is able to accurately predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients. A total of 65 breast cancer patients who received NAC at the First Affiliated Hospital of Zhejiang University (Hangzhou, China) between February 2016 and August 2017 and were recruited for the present study. Prior to and after NAC, examination by CEUS, UE or their combination was performed. Pathological results were obtained at the end of each chemotherapy cycle, based on which 41 cases were assigned to the response group and 24 to the non‑response group. Kappa values were 0.710, 0.434 and 0.836 for CEUS, UE and CEUS+UE, respectively. The area under the receiver operating characteristic curves for CEUS, UE and CEUS+UE for determining the response to NAC was 0.864 [95% confidence interval (CI), 0.765‑0.964], 0.715 (95% CI, 0.579‑0.850) and 0.910 (95% CI, 0.826‑0.993), respectively. It was identified that the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CEUS+UE were higher than those of CEUS and US individually. The prediction accuracy was 89.2, 90.8 and 100% for CEUS, UE and their combination, respectively. CEUS and UE have their own advantages in evaluating the clinical efficacy of NAC in breast cancer, and a higher accuracy was achieved when the two techniques were applied in combination. Therefore, a combination of CEUS and UE may be a preferred method for the clinical assessment of the efficacy of NAC in breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Jiang T, Huang M, Wang J, Chu Y, Zhong L and Zheng S: Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography. Exp Ther Med 17: 3655-3663, 2019.
APA
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., & Zheng, S. (2019). Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography. Experimental and Therapeutic Medicine, 17, 3655-3663. https://doi.org/10.3892/etm.2019.7353
MLA
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., Zheng, S."Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography". Experimental and Therapeutic Medicine 17.5 (2019): 3655-3663.
Chicago
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., Zheng, S."Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3655-3663. https://doi.org/10.3892/etm.2019.7353
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Jiang T, Huang M, Wang J, Chu Y, Zhong L and Zheng S: Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography. Exp Ther Med 17: 3655-3663, 2019.
APA
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., & Zheng, S. (2019). Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography. Experimental and Therapeutic Medicine, 17, 3655-3663. https://doi.org/10.3892/etm.2019.7353
MLA
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., Zheng, S."Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography". Experimental and Therapeutic Medicine 17.5 (2019): 3655-3663.
Chicago
Wang, B., Jiang, T., Huang, M., Wang, J., Chu, Y., Zhong, L., Zheng, S."Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast‑enhanced ultrasonography and ultrasound elastography". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3655-3663. https://doi.org/10.3892/etm.2019.7353
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