Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization

  • Authors:
    • Luo Li
    • Shuangcheng Chen
    • Yunwei Sun
    • Lu Kong
    • Guangping Liu
    • Pin Guo
  • View Affiliations

  • Published online on: March 8, 2019     https://doi.org/10.3892/etm.2019.7365
  • Pages: 3775-3780
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Abstract

Pituitary tumors account for 10% of intracranial cancer, and are difficult to treat with chemotherapy. The aim of the present study was to explore the role of matrine on the proliferation of pituitary cancer cells, as well as the molecular mechanism of matrine in progression and development of pituitary tumors. Matrine significantly suppressed the proliferation of pituitary cancer cells in a dose‑ and time‑dependent manner. Western blotting results showed that the phosphorylation levels of AKT serine/threonine kinase (Akt) and forkhead box O3A (Foxo3a) decreased as the concentration of matrine increased. Matrine increased the nuclear localization of Foxo3a and the expression of proapoptotic genes, such as BCL2 like 11 and BCL2 associated X apoptosis regulator, and inhibited the levels of cytoplasmic Foxo3a. In conclusion, matrine promoted cell death of pituitary cancer cells and was involved in Akt/Foxo3a signaling pathway.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li L, Chen S, Sun Y, Kong L, Liu G and Guo P: Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization. Exp Ther Med 17: 3775-3780, 2019
APA
Li, L., Chen, S., Sun, Y., Kong, L., Liu, G., & Guo, P. (2019). Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization. Experimental and Therapeutic Medicine, 17, 3775-3780. https://doi.org/10.3892/etm.2019.7365
MLA
Li, L., Chen, S., Sun, Y., Kong, L., Liu, G., Guo, P."Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization". Experimental and Therapeutic Medicine 17.5 (2019): 3775-3780.
Chicago
Li, L., Chen, S., Sun, Y., Kong, L., Liu, G., Guo, P."Matrine inhibits the proliferation of pituitary tumor cells by decreasing Foxo3a phosphorylation and promoting Foxo3a nuclear localization". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3775-3780. https://doi.org/10.3892/etm.2019.7365