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Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway

  • Authors:
    • Fu‑Bo Zhang
    • Jian‑Ping Wang
    • Hong‑Xia Zhang
    • Gui‑Mei Fan
    • Xin Cui
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China, Department of Rheumatology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3335-3342
    |
    Published online on: March 12, 2019
       https://doi.org/10.3892/etm.2019.7374
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Abstract

β‑patchoulene (β‑PAE), an active constituent of the Pogostemon cablin, is well known for its anti‑inflammatory and antioxidative functions in various diseases. However, little is known about the impact of β‑PAE on the cerebral ischemia‑reperfusion (I/R) injury. The current study aimed to determine the neuroprotective effect of β‑PAE and the underlying mechanisms on cerebral I/R injury. Following pretreatment with β‑PAE (10 mg/kg body weight) by tail intravenous injection for 1 h, Sprague‑Dawley rats were subjected to middle cerebral artery occlusion for 2 h and reperfusion for 24 h. The results indicated that pretreatment with β‑PAE could diminish the infarct volume, decrease the brain water content, reduce the neurological deficit score and restore the mitochondrial membrane potential, compared with the untreated I/R injury group. Furthermore, cell apoptosis was markedly suppressed by β‑PAE, and this effect was associated with the decreased apoptosis regulator BAX/apoptosis regulator Bcl‑2 expression ratio and caspase‑3 activity. In addition, β‑PAE significantly inhibited the release of proinflammatory factors, including tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6. Superoxide generation and malondialdehyde levels were reduced while the levels of glutathione peroxidase and superoxide dismutase were elevated following treatment with β‑PAE, indicating the antioxidative role of β‑PAE in cerebral I/R injury. Furthermore, the Toll‑like receptor 4 (TLR4)/nuclear factor‑κB (NF‑κB) signaling pathway was inhibited by β‑PAE, as demonstrated by the decreased TLR4 expression and nuclear translocation of p65, and increased IκBα level. Taken together, the results suggested that β‑PAE may exhibit a neuroprotective effect on cerebral I/R injury in rats through inactivating the TLR4/NF‑κB signaling pathway.
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View References

1 

Zhao L, Liu X, Liang J, Han S, Wang Y, Yin Y, Luo Y and Li J: Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice. Brain Res. 1503:78–88. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Jiang M, Li J, Peng Q, Liu Y, Liu W, Luo C, Peng J, Li J, Yung KK and Mo Z: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation. 11:1672014. View Article : Google Scholar : PubMed/NCBI

3 

Chien A and Vinuela F: Analyzing Circle of Willis blood flow in ischemic stroke patients through 3D stroke arterial flow estimation. Interv Neuroradiol. 23:427–432. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Zhao P, Zhou R, Zhu XY, Hao YJ, Li N, Wang J, Niu Y, Sun T, Li YX and Yu JQ: Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice. Int J Mol Med. 36:633–644. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Wu J, Chen Y, Yu S, Li L, Zhao X, Li Q, Zhao J and Zhao Y: Neuroprotective effects of sulfiredoxin-1 during cerebral ischemia/reperfusion oxidative stress injury in rats. Brain Res Bull. 132:99–108. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhou L, Bondy SC, Jian L, Wen P, Yang F, Luo H, Li W and Zhou J: Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and −8. Neuroscience. 288:105–111. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Wu JZ, Liu YH, Liang JL, Huang QH, Dou YX, Nie J, Zhuo JY, Wu X, Chen JN, Su ZR and Wu QD: Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. Phytomedicine. 39:111–118. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Chen XY, Dou YX, Luo DD, Zhang ZB, Li CL, Zeng HF, Su ZR, Xie JH, Lai XP and Li YC: β-Patchoulene from patchouli oil protects against LPS-induced acute lung injury via suppressing NF-κB and activating Nrf2 pathways. Int Immunopharmacol. 50:270–278. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhang Z, Chen X, Chen H, Wang L, Liang J, Luo D, Liu Y, Yang H, Li Y, Xie J and Su Z: Anti-inflammatory activity of β-patchoulene isolated from patchouli oil in mice. Eur J Pharmacol. 781:229–238. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Bi Y, Zhu Y, Zhang M, Zhang K, Hua X, Fang Z, Zhou J, Dai W, Cui Y, Li J and You T: Effect of shikonin on spinal cord injury in rats via regulation of HMGB1/TLR4/NF-kB signaling pathway. Cell Physiol Biochem. 43:481–491. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ntoufa S, Vilia MG, Stamatopoulos K, Ghia P and Muzio M: Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies. Semin Cancer Biol. 39:15–25. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Li X, Su L, Zhang X, Zhang C, Wang L, Li Y, Zhang Y, He T, Zhu X and Cui L: Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury. Neurol Res. 39:367–373. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Liu Y, Liang J, Wu J, Chen H, Zhang Z, Yang H, Chen L, Chen H, Su Z and Li Y: Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury. Sci Rep. 7:55912017. View Article : Google Scholar : PubMed/NCBI

14 

Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J and Chopp M: Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 32:2682–2688. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

16 

Xiong D, Deng Y, Huang B, Yin C, Liu B, Shi J and Gong Q: Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats. Int Immunopharmacol. 30:157–162. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhang L, Wang L, Ning FB, Wang T, Liang YC and Liu YL: Erythropoietin reduces hippocampus injury in neonatal rats with hypoxic ischemic brain damage via targeting matrix metalloprotein-2. Eur Rev Med Pharmacol Sci. 21:4327–4333. 2017.PubMed/NCBI

18 

Tao T, Li CL, Yang WC, Zeng XZ, Song CY, Yue ZY, Dong H and Qian H: Protective effects of propofol against whole cerebral ischemia/reperfusion injury in rats through the inhibition of the apoptosis-inducing factor pathway. Brain Res. 1644:9–14. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yuan J, Guo X, Liu Z, Zhao X, Feng Y, Song S, Cui C and Jiang P: Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death. Int J Mol Med. 41:364–372. 2018.PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, et al: Superoxide flashes in single mitochondria. Cell. 134:279–290. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lopez AD, Mathers CD, Ezzati M, Jamison DT and Murray CJ: Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data. Lancet. 367:1747–1757. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Gomis M and Dávalos A: Recanalization and reperfusion therapies of acute ischemic stroke: What have we learned, what are the major research questions and where are we headed? Front Neurol. 5:2262014. View Article : Google Scholar : PubMed/NCBI

24 

Wang M, Wang J, Liu Z, Guo X, Wang N, Jia N, Zhang Y and Yuan J: Effects of intermedin on autophagy in cerebral ischemia/reperfusion injury. Neuropeptides. 68:15–21. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Qiao Z and Xu Y: Salvianolic acid B alleviating myocardium injury in ischemia reperfusion rats. Afr J Tradit Complement Altern Med. 13:157–161. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Ming D, Songyan L, Yawen C, Na Z, Jing M, Zhaowen X, Ye L, Wa D and Jie L: Trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin-angiotensin system (RAS) and Rho kinase (ROCK) activity. Food Funct. 8:2309–2321. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Che X, Wang X, Zhang J, Peng C, Zhen Y, Shao X, Zhang G and Dong L: Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation. Am J Transl Res. 8:3319–3328. 2016.PubMed/NCBI

28 

Zhang B, Song C, Feng B and Fan W: Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-κB/PUMA signal in rats. Ther Clin Risk Manag. 12:817–824. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Miao M, Yan X, Guo L and Shao S: Effects of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in rats. Saudi Pharm J. 25:607–614. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Tan H, Chen L and Ma J: Penehyclidine hydrochloride post-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosis in rats. Exp Ther Med. 14:4272–4278. 2017.PubMed/NCBI

31 

Shabanzadeh AP, D'Onofrio PM, Monnier PP and Koeberle PD: Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke. Cell Death Dis. 6:e19672015. View Article : Google Scholar : PubMed/NCBI

32 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Broughton BR, Reutens DC and Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke. 40:e331–339. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Ren Z, Zhang R, Li Y, Li Y, Yang Z and Yang H: Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo. Int J Mol Med. 40:1444–1456. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Liu Y, Zhang L and Liang J: Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats. J Neurol Sci. 351:88–92. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K and Akira S: Pillars Article: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J Immunol. 162:3749–3752. 1999.PubMed/NCBI

37 

Wang D, Wang X, Tong W, Cui Y, Li X and Sun H: Umbelliferone alleviates lipopolysaccharide-induced inflammatory responses in acute lung injury by down-regulating TLR4/MyD88/NF-κB signaling. Inflammation. Jan 15–2019.(Epub ahead of print). View Article : Google Scholar

38 

Wan F and Lenardo MJ: The nuclear signaling of NF-kappaB: Current knowledge, new insights, and future perspectives. Cell Res. 20:24–33. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Zhang J, Fu B, Zhang X, Chen L, Zhang L, Zhao X, Bai X, Zhu C, Cui L and Wang L: Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression. Brain Res. 1528:80–88. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang FB, Wang JP, Zhang HX, Fan GM and Cui X: Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway. Exp Ther Med 17: 3335-3342, 2019.
APA
Zhang, F., Wang, J., Zhang, H., Fan, G., & Cui, X. (2019). Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 17, 3335-3342. https://doi.org/10.3892/etm.2019.7374
MLA
Zhang, F., Wang, J., Zhang, H., Fan, G., Cui, X."Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 17.5 (2019): 3335-3342.
Chicago
Zhang, F., Wang, J., Zhang, H., Fan, G., Cui, X."Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3335-3342. https://doi.org/10.3892/etm.2019.7374
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang FB, Wang JP, Zhang HX, Fan GM and Cui X: Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway. Exp Ther Med 17: 3335-3342, 2019.
APA
Zhang, F., Wang, J., Zhang, H., Fan, G., & Cui, X. (2019). Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 17, 3335-3342. https://doi.org/10.3892/etm.2019.7374
MLA
Zhang, F., Wang, J., Zhang, H., Fan, G., Cui, X."Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 17.5 (2019): 3335-3342.
Chicago
Zhang, F., Wang, J., Zhang, H., Fan, G., Cui, X."Effect of β‑patchoulene on cerebral ischemia‑reperfusion injury and the TLR4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3335-3342. https://doi.org/10.3892/etm.2019.7374
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