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Review Open Access

Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)

  • Authors:
    • Wen‑Fang Zhang
    • Yin‑Chuan Jin
    • Xiao‑Mei Li
    • Zhi Yang
    • Dong Wang
    • Jing‑Jing Cui
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Research Center, Binzhou Medical University, Yantai, Shandong 264000, P.R. China, Department of Histology and Embryology, Binzhou Medical University, Yantai, Shandong 264000, P.R. China, Department of Cardiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264000, P.R. China, Department of Medical Affairs, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3282-3290
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    Published online on: March 13, 2019
       https://doi.org/10.3892/etm.2019.7377
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Abstract

In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self‑regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro‑inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Excessive perfusion leads to failure of the body's self‑regulatory functions, which in turn increases the area of cerebral edema and aggravates cerebral ischemia. Previous studies have evaluated the satiety hormone leptin as a link between energy expenditure and obesity. Of note, leptin, which is involved in brain development, synaptic transmission and angiogenesis following ischemia/reperfusion injury, has been considered an important factor for treating ischemia/reperfusion injury. The present review outlines the discovery of leptin and discusses its association with cerebral ischemia/reperfusion.
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1 

Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, et al: Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515:431–435. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wu H, Tang C, Tai LW, Yao W, Guo P, Hong J, Yang X, Li X, Jin Z, Ke J and Wang Y: Flurbiprofen axetil attenuates cerebral ischemia reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia reperfusion. Biosci Rep. 38:BSR201715622018. View Article : Google Scholar : PubMed/NCBI

3 

Zhou H, Wang J, Jiang J, Stavrovskaya IG, Li M, Li W, Wu Q, Zhang X, Luo C, Zhou S, et al: N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. J Neurosci. 34:2967–2978. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Coutinho JM, Liebeskind DS, Slater LA, Nogueira RG, Clark W, Dávalos A, Bonafé A, Jahan R, Fischer U, Gralla J, et al: Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: A pooled analysis of the SWIFT and STAR studies. JAMA Neurol. 74:268–274. 2017. View Article : Google Scholar : PubMed/NCBI

5 

El-Ghanem M, Al-Mufti F, Thulasi V, Singh IP and Gandhi C: Expanding the treatment window for ischemic stroke through the application of novel system-based technology. Neurosurg Focus. 42:E72017. View Article : Google Scholar : PubMed/NCBI

6 

Oh HK, Choi YS, Yang YI, Kim JH, Leung PC and Choi JH: Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. Mol Hum Reprod. 19:160–168. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Gairolla J, Kler R, Modi M and Khurana D: Leptin and adiponectin: pathophysiological role and possible therapeutic target of inflammation in ischemic stroke. Rev Neurosci. 28:295–306. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Nowzari Z, Masoumi M, Nazari-Robati M, Akbari H, Shahrokhi N and Asadikaram G: Association of polymorphisms of leptin, leptin receptor and apelin receptor genes with susceptibility to coronary artery disease and hypertension. Life Sci. 207:166–171. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Deng ZH, Liao J, Zhang JY, Liang C, Song CH, Han M, Wang LH, Xue H, Zhang K, Zabeau L, et al: Inhibition of the connexin 43 elevation may be involved in the neuroprotective activity of leptin against brain ischemic injury. Cell Mol Neurobiol. 34:871–879. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Porzionato A, Rucinski M, Macchi V, Stecco C, Castagliuolo I, Malendowicz LK and De Caro R: Expression of leptin and leptin receptor isoforms in the rat and human carotid body. Brain Res. 1385:56–67. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Zhou Y and Rui L: Leptin signaling and leptin resistance. Front Med. 7:207–222. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zhang JY, Yan GT, Liao J, Deng ZH, Xue H, Wang LH and Zhang K: Leptin attenuates cerebral ischemia/reperfusion injury partially by CGRP expression. Eur J Pharmacol. 671:61–69. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Zhang JY Jr, Si YL, Liao J, Yan GT, Deng ZH, Xue H, Wang LH and Zhang K: Leptin administration alleviates ischemic brain injury in mice by reducing oxidative stress and subsequent neuronal apoptosis. J Trauma Acute Care Surg. 72:982–991. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Tsuda K: Leptin and nitric oxide production against ischemic neuronal injury. Stroke. 39:e3–e4. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Musman J, Pons S, Barau C, Caccia C, Leoni V, Berdeaux A, Ghaleh B and Morin D: Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. Free Radic Biol Med. 101:317–324. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Grabacka MM, Wilk A, Antonczyk A, Banks P, Walczyk-Tytko E, Dean M, Pierzchalska M and Reiss K: Fenofibrate induces ketone body production in melanoma and glioblastoma cells. Front Endocrinol (Lausanne). 7:52016. View Article : Google Scholar : PubMed/NCBI

17 

Ye R, Yang Q, Kong X, Li N, Zhang Y, Han J, Xiong L, Liu X and Zhao G: Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: Role of mitochondrial permeability transition. Crit Care Med. 40:2685–2693. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Schwartz MW and Baskin DG: Leptin and the brain: then and now. J Clin Investig. 123:2344–2345. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G and Friedman JM: Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA. 92:6957–6960. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425–432. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK and Friedman JM: Weight reducing effects of the plasma protein Encoded by the obese gene. Science. 269:543–546. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Niklowitz P, Rothermel J, Lass N, Barth A and Reinehr T: Bioactive leptin is stronger related to parameters of fat mass and distribution than conventionally measured leptin: Findings from a longitudinal study in obese children participating in a lifestyle intervention. Clin Chim Acta. 480:225–229. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Munzberg H and Morrison CD: Structure, production and signaling of leptin. Metabolism. 64:13–23. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Perez-Perez A, Vilarino-Garcia T, Fernandez-Riejos P, Martin-Gonzalez J, Segura-Egea JJ and Sanchez-Margalet V: Role of leptin as a link between metabolism and the immune system. Cytokine Growth Factor Rev. 35:71–84. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Kastin AJ and Pan WH: Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept. 92:37–43. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Witte AV, Kobe T, Graunke A, Schuchardt JP, Hahn A, Tesky VA, Pantel J and Flöel A: Impact of leptin on memory function and hippocampal structure in mild cognitive impairment. Hum Brain Mapp. 37:4539–4549. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Chowen JA, Argente-Arizon P, Freire-Regatillo A, Frago LM, Horvath TL and Argente J: The role of astrocytes in the hypothalamic response and adaptation to metabolic signals. Prog Neurobiol. 144:68–87. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Escobar S, Rocha A, Felip A, Carrillo M, Zanuy S, Kah O and Servili A: Leptin receptor gene in the European sea bass (Dicentrarchus labrax): Cloning, phylogeny, tissue distribution and neuroanatomical organization. Gen Comp Endocrinol. 229:100–111. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Engel O, Kolodziej S, Dirnagl U and Prinz V: Modeling stroke in mice - middle cerebral artery occlusion with the filament model. J Vis Exp. 6:24232011.

30 

Thomas SA, Preston JE, Wilson MR, Farrell CL and Segal MB: Leptin transport at the blood–cerebrospinal fluid barrier using the perfused sheep choroid plexus model. Brain Res. 895:283–290. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Kwon O, Kim KW and Kim MS: Leptin signalling pathways in hypothalamic neurons. Cell Mol Life Sci. 73:1457–1477. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Deng ZH Jr, Yan GT, Wang LH, Zhang JY, Xue H and Zhang K: Leptin relieves intestinal ischemia/reperfusion injury by promoting ERK1/2 phosphorylation and the NO signaling pathway. J Trauma Acute Care Surg. 72:143–149. 2012.PubMed/NCBI

33 

Zhang J, Deng Z, Liao J, Song C, Liang C, Xue H, Wang L, Zhang K and Yan G: Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway. J Cereb Blood Flow Metab. 33:567–574. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Zhang F, Wang S, Signore AP and Chen J: Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke. 38:2329–2336. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Amantea D, Tassorelli C, Russo R, Petrelli F, Morrone LA, Bagetta G and Corasaniti MT: Neuroprotection by leptin in a rat model of permanent cerebral ischemia: Effects on STAT3 phosphorylation in discrete cells of the brain. Cell Death Dis. 2:e2382011. View Article : Google Scholar : PubMed/NCBI

36 

Liu Z, Gan L, Zhou Z, Jin W and Sun C: SOCS3 promotes inflammation and apoptosis via inhibiting JAK2/STAT3 signaling pathway in 3T3-L1 adipocyte. Immunobiology. 220:947–953. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Wang W, Lu R, Feng DY and Zhang H: Sevoflurane inhibits glutamate-aspartate transporter and glial fibrillary acidic protein expression in hippocampal astrocytes of neonatal rats through the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Anesth Analg. 123:93–102. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Lin G, Zhang H, Sun F, Lu Z, Reed-Maldonado A, Lee YC, Wang G, Banie L and Lue TF: Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells. Transl Androl Urol. 5:167–175. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Lv J, Wang X, Liu SY, Liang PF, Feng M, Zhang LL and Xu AP: Protective effect of Fenofibrate in renal ischemia reperfusion injury: Involved in suppressing kinase 2 (JAK2)/transcription 3 (STAT3)/p53 signaling activation. Pathol Biol (Paris). 63:236–242. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Garama DJ, White CL, Balic JJ and Gough DJ: Mitochondrial STAT3: Powering up a potent factor. Cytokine. 87:20–25. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Gurzov EN, Stanley WJ, Pappas EG, Thomas HE and Gough DJ: The JAK/STAT pathway in obesity and diabetes. FEBS J. 283:3002–3015. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Meng HL, Li XX, Chen YT, Yu LJ, Zhang H, Lao JM, Zhang X and Xu Y: Neuronal soluble fas ligand drives M1-microglia polarization after cerebral ischemia. CNS Neurosci Ther. 22:771–781. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Friedman J: The long road to leptin. J Clin Invest. 126:4727–4734. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Moon HS, Dalamaga M, Kim SY, Polyzos SA, Hamnvik OP, Magkos F, Paruthi J and Mantzoros CS: Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocr Rev. 34:377–412. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Pan WW and Myers MG Jr: Leptin and the maintenance of elevated body weight. Nat Rev Neurosci. 19:95–105. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Davis C, Mudd J and Hawkins M: Neuroprotective effects of leptin in the context of obesity and metabolic disorders. Neurobiol Dis. 72:61–71. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Nuñez-Figueredo Y, Pardo-Andreu GL, Ramírez-Sánchez J, Delgado-Hernández R, Ochoa-Rodríguez E, Verdecia-Reyes Y, Naal Z, Muller AP, Portela LV and Souza DO: Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+-induced mitochondrial impairment. Brain Res Bull. 109:68–76. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Hana V, Silha JV, Justova V, Lacinova Z, Stepan JJ and Murphy LJ: The effects of GH replacement in adult GH-deficient patients: Changes in body composition without concomitant changes in the adipokines and insulin resistance. Clin Endocrinol (Oxf). 60:442–450. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG and Olson LJ: The relationship between leptin and ventilatory control in heart failure. J Card Fail. 19:756–761. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Tang H, Zhang Z, Li ZK, Lin J and Fang DZ: Association of leptin receptor gene polymorphisms with genetic susceptibility to ischemic stroke. J Stroke Cerebrovasc Dis. 24:2128–2133. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Auer MK, Ebert T, Pietzner M, Defreyne J, Fuss J, Stalla GK and T'Sjoen G: Effects of sex hormone treatment on the metabolic syndrome in transgender individuals: Focus on metabolic cytokines. J Clin Endocrinol Metab. 103:790–802. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS and Seshadri S: Serum leptin levels and the risk of stroke: The framingham study. Stroke. 46:2881–2885. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Diaz M, Chacon MR, Lopez-Bermejo A, Maymó-Masip E, Salvador C, Vendrell J, de Zegher F and Ibáñez L: Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: Divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue. J Clin Endocrinol Metab. 97:3630–3638. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Scott I, Webster BR, Chan CK, Okonkwo JU, Han K and Sack MN: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. J Biol Chem. 289:2864–2872. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Martinez-Abundis E, Rajapurohitam V, Gertler A and Karmazyn M: Identification of functional leptin receptors expressed in ventricular mitochondria. Mol Cell Biochem. 408:155–162. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Karadottir R, Cavelier P, Bergersen LH and Attwell D: NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature. 438:1162–1166. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Hamilton NB, Kolodziejczyk K, Kougioumtzidou E and Attwell D: Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia. Nature. 529:523–527. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Greco SJ, Hamzelou A, Johnston JM, Smith MA, Ashford JW and Tezapsidis N: Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons. Biochem Biophys Res Commun. 414:170–174. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Busch HJ, Schirmer SH, Jost M, van Stijn S, Peters SL, Piek JJ, Bode C, Buschmann IR and Mies G: Leptin augments cerebral hemodynamic reserve after three-vessel occlusion: Distinct effects on cerebrovascular tone and proliferation in a nonlethal model of hypoperfused rat brain. J Cereb Blood Flow Metab. 31:1085–1092. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Gleitz HF, Kramann R and Schneider RK: Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis. J Pathol. 245:138–146. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Ray A and Cleary MP: The potential role of leptin in tumor invasion and metastasis. Cytokine Growth Factor Rev. 38:80–97. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Ni H, Sun Q, Tian T, Feng X and Sun BL: Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin. Mol Med Rep. 12:2727–2734. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Zhang XG, Zhao L, Zhang Y, Li YY, Wang H, Duan GL, Xiao L, Li XR and Chen HP: Extracellular Cl(−)-free-induced cardioprotection against hypoxia/reoxygenation is associated with attenuation of mitochondrial permeability transition pore. Biomed Pharmacother. 86:637–644. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, et al: Selective inhibition of the mitochondrial permeability transition pore protects against neurodegeneration in experimental multiple sclerosis. J Biol Chem. 291:4356–4373. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Ham PB 3rd and Raju R: Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol. 157:92–116. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Holmstrom MH, Tom RZ, Bjornholm M, Garcia-Roves PM and Zierath JR: Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism. 62:1258–1267. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X and Lo EH: Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 535:551–555. 2016. View Article : Google Scholar : PubMed/NCBI

68 

Antico Arciuch VG, Elguero ME, Poderoso JJ and Carreras MC: Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal. 16:1150–1180. 2012. View Article : Google Scholar : PubMed/NCBI

69 

Valerio A, Bertolotti P, Delbarba A, Perego C, Dossena M, Ragni M, Spano P, Carruba MO, De Simoni MG and Nisoli E: Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production. J Neurochem. 116:1148–1159. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Madathil RJ, Hira RS, Stoeckl M, Sterz F, Elrod JB and Nichol G: Ischemia reperfusion injury as a modifiable therapeutic target for cardioprotection or neuroprotection in patients undergoing cardiopulmonary resuscitation. Resuscitation. 105:85–91. 2016. View Article : Google Scholar : PubMed/NCBI

71 

Vermeij JD, Westendorp WF, Dippel DW, van de Beek D and Nederkoorn PJ: Antibiotic therapy for preventing infections in people with acute stroke. Cochrane Database Syst Rev. 1:CD0085302018.PubMed/NCBI

72 

Chung HK, Kim YK, Park JH, Ryu MJ, Chang JY, Hwang JH, Lee CH, Kim SH, Kim HJ, Kweon GR, et al: The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation. Liver Int. 35:1341–1353. 2015. View Article : Google Scholar : PubMed/NCBI

73 

Rustenhoven J, Aalderink M, Scotter EL, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Curtis MA, Park TI and Dragunow M: TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function. J Neuroinflammation. 13:372016. View Article : Google Scholar : PubMed/NCBI

74 

Agrawal S, Gollapudi S, Su H and Gupta S: Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. J Clin Immunol. 31:472–478. 2011. View Article : Google Scholar : PubMed/NCBI

75 

Xu H, Qin W, Hu X, Mu S, Zhu J, Lu W and Luo Y: Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats. J Neuroinflammation. 15:832018. View Article : Google Scholar : PubMed/NCBI

76 

Rummel C: Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication. Brain Behav Immun. 54:1–14. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Lopez-Rodriguez AB, Mela V, Acaz-Fonseca E, Garcia-Segura LM and Viveros MP: CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury. Exp Neurol. 279:274–282. 2016. View Article : Google Scholar : PubMed/NCBI

78 

Flatow EA, Komegae EN, Fonseca MT, Brito CF, Musteata FM, Antunes-Rodrigues J and Steiner AA: Elucidating the role of leptin in systemic inflammation: A study targeting physiological leptin levels in rats and their macrophages. Am J Physiol Regul Integr Comp Physiol. 313:R572–R582. 2017. View Article : Google Scholar : PubMed/NCBI

79 

Astrup J, Symon L and Siesjo BK: Thresholds in cerebral ischemia-the ischemic penumbra. Stroke. 12:723–725. 1981. View Article : Google Scholar : PubMed/NCBI

80 

Stetler RA, Leak RK, Yin W, Zhang L, Wang S, Gao Y and Chen J: Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning. J Neurochem. 123 (Suppl 2):125–137. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Tan DX, Manchester LC, Qin L and Reiter RJ: Melatonin: A mitochondrial targeting molecule involving mitochondrial protection and dynamics. Int J Mol Sci. 17:E21242016. View Article : Google Scholar : PubMed/NCBI

82 

Geng HX, Li RP, Li YG, Wang XQ, Zhang L, Deng JB, Wang L and Deng JX: 14,15-EET suppresses neuronal apoptosis in ischemia-reperfusion through the mitochondrial pathway. Neurochem Res. 42:2841–2849. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Owens B: Stroke. Nature. 26:510(7506)–S12014

84 

Grummisch JA, Jadavji NM and Smith PD: tPA promotes cortical neuron survival via mTOR-dependent mechanisms. Mol Cell Neurosci. 74:25–33. 2016. View Article : Google Scholar : PubMed/NCBI

85 

Arita S, Kinoshita Y, Ushida K, Enomoto A and Inagaki-Ohara K: High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway. Arch Biochem Biophys. 610:16–24. 2016. View Article : Google Scholar : PubMed/NCBI

86 

Carboni L, Marchetti L, Lauria M, Gass P, Vollmayr B, Redfern A, Jones L, Razzoli M, Malki K, Begni V, et al: Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression. Neuropsychopharmacology. 43:234–2145. 2018. View Article : Google Scholar

87 

Yang H, Guo W, Li J, Cao S, Zhang J, Pan J, Wang Z, Wen P, Shi X and Zhang S: Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis. PLoS One. 12:e01663602017. View Article : Google Scholar : PubMed/NCBI

88 

Brüstle O, Choudhary K, Karram K, Hüttner A, Murray K, Dubois-Dalcq M and McKay RD: Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nat Biotechnol. 16:1040–1044. 1998. View Article : Google Scholar : PubMed/NCBI

89 

Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T and Nakafuku M: Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 110:429–441. 2002. View Article : Google Scholar : PubMed/NCBI

90 

Carlen M, Meletis K, Goritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MS, Naldini L, et al: Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosc. 12:259–267. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang WF, Jin YC, Li XM, Yang Z, Wang D and Cui JJ: Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Exp Ther Med 17: 3282-3290, 2019.
APA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., & Cui, J. (2019). Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Experimental and Therapeutic Medicine, 17, 3282-3290. https://doi.org/10.3892/etm.2019.7377
MLA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17.5 (2019): 3282-3290.
Chicago
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3282-3290. https://doi.org/10.3892/etm.2019.7377
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang WF, Jin YC, Li XM, Yang Z, Wang D and Cui JJ: Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Exp Ther Med 17: 3282-3290, 2019.
APA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., & Cui, J. (2019). Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Experimental and Therapeutic Medicine, 17, 3282-3290. https://doi.org/10.3892/etm.2019.7377
MLA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17.5 (2019): 3282-3290.
Chicago
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3282-3290. https://doi.org/10.3892/etm.2019.7377
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