Open Access

Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)

  • Authors:
    • Wen‑Fang Zhang
    • Yin‑Chuan Jin
    • Xiao‑Mei Li
    • Zhi Yang
    • Dong Wang
    • Jing‑Jing Cui
  • View Affiliations

  • Published online on: March 13, 2019     https://doi.org/10.3892/etm.2019.7377
  • Pages: 3282-3290
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self‑regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro‑inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Excessive perfusion leads to failure of the body's self‑regulatory functions, which in turn increases the area of cerebral edema and aggravates cerebral ischemia. Previous studies have evaluated the satiety hormone leptin as a link between energy expenditure and obesity. Of note, leptin, which is involved in brain development, synaptic transmission and angiogenesis following ischemia/reperfusion injury, has been considered an important factor for treating ischemia/reperfusion injury. The present review outlines the discovery of leptin and discusses its association with cerebral ischemia/reperfusion.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang WF, Jin YC, Li XM, Yang Z, Wang D and Cui JJ: Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Exp Ther Med 17: 3282-3290, 2019
APA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., & Cui, J. (2019). Protective effects of leptin against cerebral ischemia/reperfusion injury (Review). Experimental and Therapeutic Medicine, 17, 3282-3290. https://doi.org/10.3892/etm.2019.7377
MLA
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17.5 (2019): 3282-3290.
Chicago
Zhang, W., Jin, Y., Li, X., Yang, Z., Wang, D., Cui, J."Protective effects of leptin against cerebral ischemia/reperfusion injury (Review)". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3282-3290. https://doi.org/10.3892/etm.2019.7377