Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 17 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease

  • Authors:
    • Yanli Xia
    • Hongwei Chen
    • Hongli Xiao
    • Jing Yang
    • Zhibin Li
    • Youchun Wang
    • Tian Yang
    • Baoyong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471000, P.R. China
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3423-3428
    |
    Published online on: March 13, 2019
       https://doi.org/10.3892/etm.2019.7389
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Immune regulation mechanism of vitamin D level and interleukin (IL)‑17/IL‑17 receptor (IL‑17R) pathway in Crohn's disease was studied. Of 40 clean mature healthy rats, 10 rats were used as control group based on random number table, the remaining 30 rats to establish Crohn's disease rat models. After successful modeling, 30 rats were divided into model group, low‑dose group and high‑dose group with random number table. On the 1st day after modeling, rats in low‑dose group were given a single dose of 1,750 IU of vitamin D, and rats in high‑dose group a single dose of 7,500 IU of vitamin D. Changes in the condition of rats after modeling were observed and scored. Enzyme‑linked immunosorbent assay was used for detecting IL‑12, IL‑17 and CXCL11 levels, western blotting for detecting IL‑17R level, and flow cytometry for detecting Th1 cell and Th17 cell levels in the lamina propria of colon mucosa. Disease activity index scores were significantly lower in low‑dose group and high‑dose group of rats than those in model group (P<0.05). Those were significantly lower in high‑dose group of rats than those in low‑dose group (P<0.05). IL‑17 and IL‑17R levels were significantly lower in high‑dose group of rats than those in low‑dose group (P<0.05). Th1 cell level was significantly higher in high‑dose group of rats than that in low‑dose group (P<0.05), but Th17 cell level was lower than that in low‑dose group (P<0.05). IL-12 levels were significantly higher in model group, low-dose group and highdose group of rats than those in control group (P<0.05). CXCL11 levels were significantly lower in model group, low-dose group and high-dose group of rats than those in control group (P<0.05). Vitamin D can effectively treat Crohn's disease, which may improve the chemotaxis and differentiation of Th1 cells by inhibiting IL‑17/IL‑17R pathway, thereby improving immune function and reducing the severity of disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, et al: A frameshift in CSF2RB predominant among Ashkenazi jews increases risk for Crohn's disease and reduces monocyte signaling via GM-CSF. Gastroenterology. 151:710–723.e2. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ananthakrishnan AN, Huang H, Nguyen DD, Sauk J, Yajnik V and Xavier RJ: Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: Analysis of a North American cohort. Am J Gastroenterol. 109:395–400. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, et al: The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 15:382–392. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, et al: International inflammatory bowel disease genetics consortium: Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: A genetic association study. Lancet. 387:156–167. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, Blank MA, Johanns J, Gao LL, Miao Y, et al: UNITI–IM-UNITI Study Group: Ustekinumab as induction and maintenance therapy for Crohn's disease. N Engl J Med. 375:1946–1960. 2016. View Article : Google Scholar : PubMed/NCBI

6 

De Cruz P, Kamm MA, Hamilton AL, Ritchie KJ, Krejany EO, Gorelik A, Liew D, Prideaux L, Lawrance IC, Andrews JM, et al: Crohn's disease management after intestinal resection: A randomised trial. Lancet. 385:1406–1417. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Del Pinto R, Pietropaoli D, Chandar AK, Ferri C and Cominelli F: Association between inflammatory bowel disease and vitamin D deficiency: A systematic review and meta-analysis. Inflamm Bowel Dis. 21:2708–2717. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Suibhne TN, Cox G, Healy M, O'Morain C and O'Sullivan M: Vitamin D deficiency in Crohn's disease: Prevalence, risk factors and supplement use in an outpatient setting. J Crohn's Colitis. 6:182–188. 2012. View Article : Google Scholar

9 

Raftery T, Martineau AR, Greiller CL, Ghosh S, McNamara D, Bennett K, Meddings J and O'Sullivan M: Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn's disease: Results from a randomised double-blind placebo-controlled study. United European Gastroenterol J. 3:294–302. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Narula N, Cooray M, Anglin R, Muqtadir Z, Narula A and Marshall JK: Impact of high-dose vitamin D3 supplementation in patients with Crohn's disease in remission: A pilot randomized double-blind controlled study. Dig Dis Sci. 62:448–455. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Monin L, Gudjonsson JE, Childs EE, Amatya N, Xing X, Verma AH, Coleman BM, Garg AV, Killeen M, Mathers A, et al: MCPIP1/regnase-1 restricts IL-17A- and IL-17C-dependent skin inflammation. J Immunol. 198:767–775. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, et al: IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host Microbe. 20:596–605. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Monteleone G, Neurath MF, Ardizzone S, Di Sabatino A, Fantini MC, Castiglione F, Scribano ML, Armuzzi A, Caprioli F, Sturniolo GC, et al: Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 372:1104–1113. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Dyring-Andersen B, Bonefeld CM, Bzorek M, Løvendorf MB, Lauritsen JP, Skov L and Geisler C: The Vitamin D analogue calcipotriol reduces the frequency of CD8+ IL-17+ T cells in psoriasis lesions. Scand J Immunol. 82:84–91. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Cantorna MT, Snyder L, Lin YD and Yang L: Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 7:3011–3021. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Gomollón F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, Peyrin-Biroulet L, Cullen GJ, Daperno M, Kucharzik T, et al: ECCO: 3rd European evidence-based consensus on the diagnosis and management of Crohn's disease 2016: Part 1: Diagnosis and medical management. J Crohn's Colitis. 11:3–25. 2017. View Article : Google Scholar

17 

Gharib H, Papini E, Garber JR, Duick DS, Harrell RM, Hegedüs L, Paschke R, Valcavi R and Vitti P; AACE/ACE/AME Task Force on Thyroid Nodules, : American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules - 2016 Update. Endocr Pract. 22:622–639. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Sadeghian M, Saneei P, Siassi F and Esmaillzadeh A: Vitamin D status in relation to Crohn's disease: Meta-analysis of observational studies. Nutrition. 32:505–514. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, et al: Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation. Immunity. 43:739–750. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kim J, Bissonnette R, Lee J, Correa da Rosa J, Suárez-Fariñas M, Lowes MA and Krueger JG: The spectrum of mild to severe psoriasis vulgaris is defined by a common activation of IL-17 pathway genes, but with key differences in immune regulatory genes. J Invest Dermatol. 136:2173–2182. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Marchant A, Amedei A, Azzurri A, Vekemans J, Benagiano M, Tamburini C, Lienhardt C, Corrah T, McAdam KP, Romagnani S, et al: Polarization of PPD-specific T-cell response of patients with tuberculosis from Th0 to Th1 profile after successful antimycobacterial therapy or in vitro conditioning with interferon-alpha or interleukin-12. Am J Respir Cell Mol Biol. 24:187–194. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Liu Z, Wang M, Zhou S, Ma J, Shi Y, Peng J, Hou M and Guo C: Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia. J Transl Med. 14:3012016. View Article : Google Scholar : PubMed/NCBI

23 

Brand S: Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut. 58:1152–1167. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xia Y, Chen H, Xiao H, Yang J, Li Z, Wang Y, Yang T and Wang B: Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease. Exp Ther Med 17: 3423-3428, 2019.
APA
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y. ... Wang, B. (2019). Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease. Experimental and Therapeutic Medicine, 17, 3423-3428. https://doi.org/10.3892/etm.2019.7389
MLA
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y., Yang, T., Wang, B."Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease". Experimental and Therapeutic Medicine 17.5 (2019): 3423-3428.
Chicago
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y., Yang, T., Wang, B."Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3423-3428. https://doi.org/10.3892/etm.2019.7389
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Y, Chen H, Xiao H, Yang J, Li Z, Wang Y, Yang T and Wang B: Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease. Exp Ther Med 17: 3423-3428, 2019.
APA
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y. ... Wang, B. (2019). Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease. Experimental and Therapeutic Medicine, 17, 3423-3428. https://doi.org/10.3892/etm.2019.7389
MLA
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y., Yang, T., Wang, B."Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease". Experimental and Therapeutic Medicine 17.5 (2019): 3423-3428.
Chicago
Xia, Y., Chen, H., Xiao, H., Yang, J., Li, Z., Wang, Y., Yang, T., Wang, B."Immune regulation mechanism of vitamin D level and IL‑17/IL‑17R pathway in Crohn's disease". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3423-3428. https://doi.org/10.3892/etm.2019.7389
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team