Analysis of the value and correlation of IGF‑1 with GH and IGFBP‑3 in the diagnosis of dwarfism

Wang,Yun; Zhang,He; Cao,Meng; Kong,Lingfeng; Ge,Xiaoli

doi:10.3892/etm.2019.7393

Analysis of the value and correlation of IGF‑1 with GH and IGFBP‑3 in the diagnosis of dwarfism

Authors:
- Yun Wang
- He Zhang
- Meng Cao
- Lingfeng Kong
- Xiaoli Ge
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Affiliations: Department of Pediatrics, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214000, P.R. China, Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China
Published online on: March 13, 2019 https://doi.org/10.3892/etm.2019.7393
Pages: 3689-3693
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation between the value of insulin‑like growth factor‑1 (IGF‑1) in the diagnosis of dwarfism and the levels of growth hormone (GH) and insulin‑like growth factor binding protein‑3 (IGFBP‑3) was investigated. From April 2014 to June 2017, 122 children with dwarfism who were treated in The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University and The First Affiliated Hospital of Xinxiang Medical University were selected as the experimental group, and 51 normal children as the control group. The basic information was recorded in detail; serum GH and IGFBP‑3 levels were measured using an arginine stimulation test and an insulin hypoglycemia stimulation test, respectively. According to the peak of GH in the experimental group, there were 65 cases of growth hormone deficiency (GHD) and 57 cases of idiopathic short stature (ISS). The expression levels of IGF‑1 of the serum in the experimental and control group were detected by chemiluminescence immunoassay (CLIA). The correlation between IGF‑1 and GH, IGF‑1 and IGFBP‑3 was analyzed. The expression level of serum IGF‑1 in GHD group was significantly lower than that in the ISS group (P<0.05). The expression level of serum IGF‑1 in GHD group was significantly lower than that in the control group (P<0.05). The expression level of serum IGF‑1 in ISS group was significantly lower than that in the control group (P<0.05). The results of partial correlation studies showed that IGF‑1 is positively correlated with GH and IGFBP‑3. Detection of GH and IGFBP‑3 are important for the early diagnosis and comprehensive evaluation of children with dwarfism, and also in the detection of IGF‑1 can reflect the therapeutic effect of dwarfism on recombinant human growth hormone (rhGH) treatment, which is worthy of application in clinics.

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