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Article

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

  • Authors:
    • Xiushan Li
    • Shujing Qi
    • Dongzhou Ma
    • Jinbiao Fan
    • Jingtao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. China, Department of Nutrition, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. China
  • Pages: 4703-4708
    |
    Published online on: April 5, 2019
       https://doi.org/10.3892/etm.2019.7468
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Abstract

Long non‑coding RNAs (lncRNAs) are hypothesized to regulate numerous biological behaviors in human cancers. The present study aimed to explore the roles of lncRNA bladder cancer associated transcript 1 (BLACAT1) in glioma. The expression of BLACAT1 in glioma tissues and cell lines was determined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). CCK‑8 assay, colony formation assay, wound healing assay and Transwell invasion assay were used to explore the roles of BLACAT1 in glioma cells. RT‑qPCR and western blot analysis were used to determine the BLACAT1 molecular mechanism. The findings demonstrated that lncRNA BLACAT1 was overexpressed in glioma tissues and cell lines. High BLACAT1 expression was correlated with high tumor grade in glioma patients. Functional assays determined that BLACAT1 promoted glioma cell proliferation, migration, invasion and epithelial‑mesenchymal transition in vitro. In addition, it was demonstrated that BLACAT1 activated the Wnt/β‑catenin signaling pathway. In conclusion, BLACAT1 may serve as an oncogenic lncRNA in glioma progression via activation of the Wnt/β‑catenin signaling pathway. Therefore, BLACAT1 may be a novel therapeutic target for glioma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Qi S, Ma D, Fan J and Wang J: Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling. Exp Ther Med 17: 4703-4708, 2019.
APA
Li, X., Qi, S., Ma, D., Fan, J., & Wang, J. (2019). Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling. Experimental and Therapeutic Medicine, 17, 4703-4708. https://doi.org/10.3892/etm.2019.7468
MLA
Li, X., Qi, S., Ma, D., Fan, J., Wang, J."Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling". Experimental and Therapeutic Medicine 17.6 (2019): 4703-4708.
Chicago
Li, X., Qi, S., Ma, D., Fan, J., Wang, J."Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4703-4708. https://doi.org/10.3892/etm.2019.7468
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Qi S, Ma D, Fan J and Wang J: Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling. Exp Ther Med 17: 4703-4708, 2019.
APA
Li, X., Qi, S., Ma, D., Fan, J., & Wang, J. (2019). Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling. Experimental and Therapeutic Medicine, 17, 4703-4708. https://doi.org/10.3892/etm.2019.7468
MLA
Li, X., Qi, S., Ma, D., Fan, J., Wang, J."Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling". Experimental and Therapeutic Medicine 17.6 (2019): 4703-4708.
Chicago
Li, X., Qi, S., Ma, D., Fan, J., Wang, J."Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4703-4708. https://doi.org/10.3892/etm.2019.7468
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